Potential Overtreatment and Undertreatment of Type 2 Diabetes Mellitus in Long-Term Care Facilities: A Systematic Review

Author(s):  
Jacquelina Stasinopoulos BHumNut ◽  
Stephen J. Wood ◽  
J. Simon Bell ◽  
Jo-Anne Manski-Nankervis ◽  
Michelle Hogan ◽  
...  
2013 ◽  
Vol 61 (12) ◽  
pp. 2103-2110 ◽  
Author(s):  
Naushira Pandya ◽  
Wenhui Wei ◽  
Juliana L. Meyers ◽  
Brett S. Kilpatrick ◽  
Keith L. Davis

Author(s):  
Thanitsara Rittiphairoj ◽  
Krit Pongpirul ◽  
Kantima Janchot ◽  
Noel T Mueller ◽  
Tianjing Li

ABSTRACT This systematic review aimed to evaluate the effectiveness and safety of probiotics for glycemic control in adults with impaired glucose control, including prediabetes and type 2 diabetes mellitus (T2DM). We searched PubMed, Embase, and Cochrane databases, and trial registries up to February 2019. We included randomized controlled trials (RCTs) of participants with prediabetes or T2DM. Eligible trials compared probiotics versus either placebo, no intervention, or comparison probiotics, or compared synbiotics versus prebiotics. Primary outcomes were mean change in fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) from baseline to short term (<12 wk) and long term (≥12 wk). We performed meta-analyses using the random-effects model. We included 28 RCTs (1947 participants). Overall, probiotics reduced FBG more than the placebo/no intervention group with a mean difference (MD) of –12.99 mg/dL (95% CI: –23.55, –2.42; P value: 0.016) over the short term; and –2.99 mg/dL (95% CI: –5.84, –0.13; P value: 0.040) over the long term. There was also some evidence for reduced HbA1c in the probiotics group at both short term (MD: –0.17; 95% CI: –0.37, 0.02; P value: 0.084) and long term (MD: –0.14; 95% CI: –0.34, 0.06; P value: 0.172), however, these did not reach statistical significance possibly because only a few trials reported HbA1c as an outcome. Subgroup analyses showed a greater reduction in HbA1c in participants not receiving insulin therapy than those receiving insulin therapy. Furthermore, the effect of probiotics on the reduction of FBG was more pronounced in participants with FBG >130 mg/dL and those not receiving insulin therapy than their counterparts. Probiotics were also effective in lowering serum cholesterol over the short and long term. In conclusion, we found that probiotics may have a glucose-lowering effect in T2DM participants. The effect appeared to be stronger in participants with poorly controlled diabetes and those not on insulin therapy. Systematic review registration: CRD42019121682.


2019 ◽  
Vol 7 (3) ◽  
Author(s):  
Karina Megasari Winahyu ◽  
Revi Anggita ◽  
Giri Widakdo

Diabetes mellitus as a chronic disease requires a long-term care, which influence the quality of life (QOL). A mechanism perceived by the patients who engage in long-term treatment, such as self-efficacy (SE) is prerequisite for the success of disease management. The study aimed to identify the relationship between characteristics of patients, SE and domains of QOL among patients with type 2 diabetes mellitus (T2DM) living in community. The study used a correlational analytical with a cross-sectional approach and recruited 105 patients with type 2 diabetes in Sukasari Public Health Center, Tangerang. Self-administered questionnaires were used to measure sociodemographic of T2DM patients, while the Diabetes Management Self-Efficacy Scale (DMSES) UK and Asian Diabetes Quality of Life (Asian DQOL) were used to measure SF and QOL, respectively. Data were analyzed using Spearman Rank-Order Correlation. The study revealed that characteristics of patients, including age and period of illness were negatively associated with memory and cognition domains of QOL, while years of education positively associated interpersonal relationship domains of QOL. For SE, it was positively significant associated with diet habit, energy, and financial aspects domains of QOL. The SE was positively associated with the QOL (r=0.31; p-value ≤ 0.01). The SE is relationship with QOL of T2DM. Therefore,  health care provider should need to maintain the domains of QOL through improving SE, while considering the characteristics of T2DM patients, including age, period of illness, and years of education.


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