Epidemiology of Polypharmacy in the General Population: 27-Year Prospective Cohort Study

2020 ◽  
Vol 21 (8) ◽  
pp. 1177-1179
Author(s):  
Silvan Licher ◽  
Brenda C.T. Kieboom ◽  
Loes E. Visser ◽  
Gijsbertus Ziere ◽  
Rikje Ruiter ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Prospective Cohort Study ◽  
Prospective Cohort

Physical comorbidity in Older-Age Bipolar Disorder (OABD) compared to the general population - a 3-year longitudinal prospective cohort study

2021 ◽  
Author(s):  
Alexandra J.M. Beunders ◽  
Almar A.L. Kok ◽  
Panagiotis C. Kosmas ◽  
Aartjan T.F. Beekman ◽  
Caroline M. Sonnenberg ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cohort Study ◽  
General Population ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Older Age

scholarly journals Response to Letter Regarding Article, “Visible Age-Related Signs and Risk of Ischemic Heart Disease in the General Population: A Prospective Cohort Study”

Circulation ◽  
2014 ◽  
Vol 130 (24) ◽  
Author(s):  
Mette Christoffersen ◽  
Ruth Frikke-Schmidt ◽  
Peter Schnohr ◽  
Gorm B. Jensen ◽  
Børge G. Nordestgaard ◽  
...  
Keyword(s):  
Cohort Study ◽  
Heart Disease ◽  
General Population ◽  
Ischemic Heart Disease ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Ischemic Heart ◽  
Age Related

scholarly journals Sperm mitochondrial DNA biomarkers and couple fecundity

2020 ◽  
Vol 35 (11) ◽  
pp. 2619-2625
Author(s):  
Allyson J Rosati ◽  
Brian W Whitcomb ◽  
Nicole Brandon ◽  
Germaine M Buck Louis ◽  
Sunni L Mumford ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cohort Study ◽  
General Population ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
National Institutes Of Health ◽  
Fertility Treatment ◽  
Semen Parameters ◽  
Lower Probability ◽  
Lower Odds

Abstract STUDY QUESTION Do sperm mitochondrial DNA measures predict probability of pregnancy among couples in the general population? SUMMARY ANSWER Those with high sperm mitochondrial DNA copy number (mtDNAcn) had as much as 50% lower odds of cycle-specific pregnancy, and 18% lower probability of pregnancy within 12 months. WHAT IS KNOWN ALREADY Semen parameters have been found to poorly predict reproductive success yet are the most prevalent diagnostic tool for male infertility. Increased sperm mtDNAcn and mitochondrial DNA deletions (mtDNAdel) have been associated with decreased semen quality and lower odds of fertilization in men seeking fertility treatment. STUDY DESIGN, SIZE, DURATION A population-based prospective cohort study of couples discontinuing contraception to become pregnant recruited from 16 US counties from 2005 to 2009 followed for up to 16 months. PARTICIPANTS/MATERIALS, SETTING, METHODS Sperm mtDNAcn and mtDNAdel from 384 semen samples were assessed via triplex probe-based quantitative PCR. Probability of pregnancy within 1 year was compared by mitochondrial DNA, and discrete-time proportional hazards models were used to evaluate the relations with time-to-pregnancy (TTP) with adjustment for covariates. MAIN RESULTS AND THE ROLE OF CHANCE Higher sperm mtDNAcn was associated with lower pregnancy probability within 12 months and longer TTP. In unadjusted comparisons by quartile (Q), those in Q4 had a pregnancy probability of 63.5% (95% CI: 53.1% to 73.1%) compared to 82.3% (95% CI: 73.2% to 89.9%) for Q1 (P = 0.002). Similar results were observed in survival analyses adjusting for covariates to estimate fecundability odds ratios (FORs) comparing mtDNAcn in quartiles. Relative to those in Q1 of mtDNAcn, FORs (95% CI) were for Q2 of 0.78 (0.52 to 1.16), Q3 of 0.65 (0.44 to 0.96) and Q4 of 0.55 (0.37 to 0.81), and this trend of decreasing fecundability with increasing mtDNAcn quartile was statistically significant (FOR per log mtDNAcn = 0.37; P < 0.001). Sperm mtDNAdel was not associated with TTP. LIMITATIONS, REASONS FOR CAUTION This prospective cohort study consisted primarily of Caucasian men and women and thus large diverse cohorts are necessary to confirm the associations between sperm mtDNAcn and couple pregnancy success in other races/ethnicities. WIDER IMPLICATIONS OF THE FINDINGS Our results demonstrate that sperm mtDNAcn has utility as a biomarker of male reproductive health and probability of pregnancy success in the general population. STUDY FUNDING/COMPETING INTEREST(S) This work was funded in part by the National Institute of Environmental Health Sciences, National Institutes of Health (R01-ES028298; PI: J.R.P.) and the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (Contracts N01-HD-3-3355, N01-HD-3-3356 and N01-HD-3-3358). The authors declare no competing interests. TRIAL REGISTRATION NUMBER N/A

Mediterranean diet and mortality in the elderly: a prospective cohort study and a meta-analysis

2018 ◽  
Vol 120 (8) ◽  
pp. 841-854 ◽  
Author(s):  
Marialaura Bonaccio ◽  
Augusto Di Castelnuovo ◽  
Simona Costanzo ◽  
Alessandro Gialluisi ◽  
Mariarosaria Persichillo ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Mediterranean Diet ◽  
Prospective Cohort Study ◽  
Prospective Studies ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Meta Analysis ◽  
The Elderly ◽  
Prolonged Survival

AbstractThe Mediterranean diet (MD) has been associated with prolonged survival in the general population, but no meta-analysis has apparently investigated the potential health benefits in relation to mortality in the elderly. We performed a longitudinal analysis on 5200 individuals aged ≥65 years identified within the general population recruited in the Moli-sani study cohort (2005–2010). Adherence to the MD was appraised by the a priori Mediterranean diet score (MDS; range 0–9). Survival estimates were derived using Cox regression and competing risk models. For the meta-analysis, PubMed and Scopus databases were searched from inception until April 2018 to identify prospective studies on the MD and death risk in the elderly. Over a median follow-up of 8·1 years, a total of 900 deaths were ascertained in the elderly sub-sample of the Moli-sani cohort. A one-point increase in the MDS was associated with lower risk of all-cause, coronary artery disease/cerebrovascular and non-cardiovascular/non-cancer mortality (multi-variable hazard ratio (HR)=0·94; 95 % CI 0·90, 0·98; HR=0·91; 95 % CI 0·83, 0·99 and HR=0·89; 95 % CI 0·81, 0·96, respectively). In a meta-analysis of seven prospective studies, including our results, for a total of 11 738 participants and 3874 deaths, one-point increment in MDS was associated with 5 % (4–7 %) lower risk of all-cause death. An inverse linear dose–response relationship was found from a meta-analysis including three studies. In conclusion, a prospective cohort study and a meta-analysis showed that closer adherence to the MD was associated with prolonged survival in elderly individuals, suggesting the appropriateness for older persons to adopt/preserve the MD to maximise their prospects for survival.

Night work and breast cancer risk in a general population prospective cohort study in The Netherlands

2014 ◽  
Vol 29 (8) ◽  
pp. 577-584 ◽  
Author(s):  
Lando L. J. Koppes ◽  
Goedele A. Geuskens ◽  
Anjoeka Pronk ◽  
Roel C. H. Vermeulen ◽  
Ernest M. M. de Vroome
Keyword(s):  
Breast Cancer ◽  
Cohort Study ◽  
Breast Cancer Risk ◽  
General Population ◽  
Cancer Risk ◽  
The Netherlands ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Night Work

scholarly journals Effects of whole-body MRI on outpatient health service costs: a general-population prospective cohort study in Mecklenburg-Vorpommern, Germany

BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e056572
Author(s):  
Carsten Oliver Schmidt ◽  
Elizabeth Sierocinski ◽  
Sebastian Baumeister ◽  
Katrin Hegenscheid ◽  
Henry Völzke ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Health Service ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Population Based ◽  
Whole Body ◽  
Service Utilisation ◽  
Specialist Care ◽  
Whole Body Mri

ObjectiveWhole-body MRI (wb-MRI) is increasingly used in research and screening but little is known about the effects of incidental findings (IFs) on health service utilisation and costs. Such effects are particularly critical in an observational study. Our principal research question was therefore how participation in a wb-MRI examination with its resemblance to a population-based health screening is associated with outpatient service costs.DesignProspective cohort study.SettingGeneral population Mecklenburg-Vorpommern, Germany.ParticipantsAnalyses included 5019 participants of the Study of Health in Pomerania with statutory health insurance data. 2969 took part in a wb-MRI examination in addition to a clinical examination programme that was administered to all participants. MRI non-participants served as a quasi-experimental control group with propensity score weighting to account for baseline differences.Primary and secondary outcome measuresOutpatient costs (total healthcare usage, primary care, specialist care, laboratory tests, imaging) during 24 months after the examination were retrieved from claims data. Two-part models were used to compute treatment effects.ResultsIn total, 1366 potentially relevant IFs were disclosed to 948 MRI participants (32% of all participants); most concerned masses and lesions (769 participants, 81%). Costs for outpatient care during the 2-year observation period amounted to an average of €2547 (95% CI 2424 to 2671) for MRI non-participants and to €2839 (95% CI 2741 to 2936) for MRI participants, indicating an increase of €295 (95% CI 134 to 456) per participant which corresponds to 11.6% (95% CI 5.2% to 17.9%). The cost increase was sustained rather than being a short-term spike. Imaging and specialist care related costs were the main contributors to the increase in costs.ConclusionsCommunicated findings from population-based wb-MRI substantially impacted health service utilisation and costs. This introduced bias into the natural course of healthcare utilisation and should be taken care for in any longitudinal analyses.

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