Clinical Use of Curcumin in Depression: A Meta-Analysis

2017 ◽  
Vol 18 (6) ◽  
pp. 503-508 ◽  
Author(s):  
Qin Xiang Ng ◽  
Shawn Shao Hong Koh ◽  
Hwei Wuen Chan ◽  
Collin Yih Xian Ho
Keyword(s):  
Meta Analysis ◽  
Clinical Use

Clinical use of Hypericum perforatum (St John's wort) in depression: A meta-analysis

2017 ◽  
Vol 210 ◽  
pp. 211-221 ◽  
Author(s):  
Qin Xiang Ng ◽  
Nandini Venkatanarayanan ◽  
Collin Yih Xian Ho
Keyword(s):  
Hypericum Perforatum ◽  
Meta Analysis ◽  
Clinical Use ◽  
St John’S Wort ◽  
St John's Wort

scholarly journals Concordance and incongruence in preclinical anxiety models: systematic review and meta-analyses

2015 ◽  
Author(s):  
Farhan Mohammad ◽  
Joses Ho ◽  
Jia Hern Woo ◽  
Chun Lei Lim ◽  
Dennis Jun Jie Poon ◽  
...  
Keyword(s):  
Systematic Review ◽  
Publication Bias ◽  
Social Isolation ◽  
Gene Knockout ◽  
Meta Analysis ◽  
Receptor Gene ◽  
List Type ◽  
Clinical Use ◽  
Defense Behavior ◽  
Meta Analyses

AbstractRodent defense behavior assays have been widely used as preclinical models of anxiety to study possibly therapeutic anxiety-reducing interventions. However, some proposed anxiety-modulating factors—genes, drugs and stressors—have had discordant effects across different studies. To reconcile the effect sizes of purported anxiety factors, we conducted systematic review and meta-analyses of the literature on ten anxiety-linked interventions, as examined in the elevated plus maze, open field and light-dark box assays. Diazepam, 5-HT1A receptor gene knockout and overexpression, SERT gene knockout and overexpression, pain, restraint, social isolation, corticotropin-releasing hormone and Crhr1 were selected for review. Eight interventions had statistically significant effects on rodent anxiety, while Htr1a overexpression and Crh knockout did not. Evidence for publication bias was found in the diazepam, Htt knockout, and social isolation literatures. The Htr1a and Crhr1 results indicate a disconnect between preclinical science and clinical research. Furthermore, the meta-analytic data confirmed that genetic SERT anxiety effects were paradoxical in the context of the clinical use of SERT inhibitors to reduce anxiety.HighlightsMeta-analysis shows eight rodent anxiety factors have at least moderate effects.Publication bias affects four of the anxiety interventions.Preclinical rodent anxiety results appear disconnected from clinical efforts.Serotonin transporter gene lesion effects are paradoxical with reuptake inhibitors clinical use.

Imaging for low back pain: is clinical use consistent with guidelines? A systematic review and meta-analysis

2018 ◽  
Vol 18 (12) ◽  
pp. 2266-2277 ◽  
Author(s):  
Hazel J. Jenkins ◽  
Aron S. Downie ◽  
Chris G. Maher ◽  
Niamh A. Moloney ◽  
John S. Magnussen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Low Back Pain ◽  
Back Pain ◽  
Meta Analysis ◽  
Clinical Use ◽  
Low Back

Abstract 15024: Efficacy of Bretylium in Termination of Treatment Resistant Ventricular Tachycardia and Ventricular Fibrillation

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Janos Molnar ◽  
John C Somberg
Keyword(s):  
Ventricular Tachycardia ◽  
Ventricular Fibrillation ◽  
Meta Analysis ◽  
Controlled Clinical Trial ◽  
Clinical Use ◽  
Second Line ◽  
Treatment Resistant ◽  
Life Threatening ◽  
Pharmacologic Therapies ◽  
The U.S

Bretylium is the only drug approved by the FDA specifically to terminate ventricular fibrillation (VF). It has also been approved to treat life threatening ventricular tachycardia (VT) as a second line agent. Due to shortage of drug substance, bretylium became unavailable for clinical use and has been dropped from ACLS guidelines in 2000. Recently, intravenous (IV) bretylium became available again in the U.S. This study evaluated the efficacy of bretylium IV in the termination of treatment resistant VT and VF. In 4 studies, a total of 85 patients with sustained VT and/or VF were administered IV bretylium 5 mg/kg: 23 patients had VT and 62 had VF. Resistant VT/VF was defined as VT or VF that could not be terminated by shock or other anti-arrhythmics or recurred before bretylium was administered. All patients received IV lidocaine; 71 received between 1 to 5 additional antiarrhythmics, and all patients with VF received DC shocks and failed all pharmacologic therapies prior to bretylium administration. Overall, 61 patients (72%) were successfully treated with IV bretylium and 31 survived to discharge from the hospital (36%). A meta-analysis of these studies indicates that the weighted conversion rate across the studies was 70% (see figure). The only study that compared IV bretylium and amiodarone did not find superiority of amiodarone in the suppression of hemodynamically destabilizing VT or VF. In patients with resistant VT or VF bretylium is reported to be effective in acute termination of the VT or VF that otherwise was not responsive to shock or other anti-arrhythmic drugs. These results suggest that bretylium should be employed in the pharmacotherapy of VT and VF when DC shock or other anti-arrhythmic drugs fail. The studies this report is based on are small studies and thus there is a need for a large controlled clinical trial to provide a better understanding of bretyliums effectiveness and if a higher than 30 mg/kg dose of bretylium would be more effective.

scholarly journals Genetic testing for indeterminate thyroid cytology: review and meta-analysis

2018 ◽  
Vol 25 (3) ◽  
pp. R163-R177 ◽  
Author(s):  
Sergio Vargas-Salas ◽  
José R Martínez ◽  
Soledad Urra ◽  
José Miguel Domínguez ◽  
Natalia Mena ◽  
...  
Keyword(s):  
Clinical Performance ◽  
Meta Analysis ◽  
Molecular Testing ◽  
Clinical Use ◽  
Thyroid Cytology ◽  
Molecular Tests ◽  
Indeterminate Nodule ◽  
Health Need ◽  
The Impact

Thyroid cancer is the most frequent endocrine malignancy, and its incidence is increasing. A current limitation of cytological evaluation of thyroid nodules is that 20–25% are reported as indeterminate. Therefore, an important challenge for clinicians is to determine whether an indeterminate nodule is malignant, and should undergo surgery, or benign, and should be recommended to follow-up. The emergence of precision medicine has offered a valuable solution for this problem, with four tests currently available for the molecular diagnosis of indeterminate cytologies. However, efforts to critically analyze the quality of the accumulated evidence are scarce. This systematic review and meta-analysis is aimed to contribute to a better knowledge about the four available molecular tests, their technical characteristics, clinical performance, and ultimately to help clinicians to make better decisions to provide the best care options possible. For this purpose, we address three critical topics: (i) the proper theoretical accuracy, considering the intended clinical use of the test (rule-in vs rule-out) and the impact on clinical decisions; (ii) the quality of the evidence reported for each test (iii) and how accurate and effective have the tests proved to be after their clinical use. Together with the upcoming evidence, this work provides significant and useful information for healthcare system decision-makers to consider the use of molecular testing as a public health need, avoiding unnecessary surgical risks and costs.

scholarly journals A meta-analysis of published studies of endothelial dysfunction does not support its routine clinical use

2015 ◽  
Vol 69 (6) ◽  
pp. 649-658 ◽  
Author(s):  
A. Cardona ◽  
S. R. Kondapally Seshasai ◽  
J. Davey ◽  
A. L. Arrebola-Moreno ◽  
G. Ambrosio ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Meta Analysis ◽  
Clinical Use

Clinical use of semantic space models in psychiatry and neurology: A systematic review and meta-analysis

2018 ◽  
Vol 93 ◽  
pp. 85-92 ◽  
Author(s):  
J.N. de Boer ◽  
A.E. Voppel ◽  
M.J.H. Begemann ◽  
H.G. Schnack ◽  
F. Wijnen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Semantic Space ◽  
Clinical Use ◽  
Semantic Space Models

scholarly journals Re: A Meta-Analysis of the Clinical Use of Curcumin for Irritable Bowel Syndrome

2019 ◽  
Vol 8 (11) ◽  
pp. 1885 ◽  
Author(s):  
Laura Appleton ◽  
Andrew S. Day
Keyword(s):  
Irritable Bowel Syndrome ◽  
Meta Analysis ◽  
Clinical Use ◽  
Irritable Bowel

We read with interest the article by Ng et al [...]

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