Quetiapine Induced Urinary Dysfunction: An Adverse Anticholinergic Effect Needing Recognition

2017 ◽  
Vol 18 (3) ◽  
pp. B6 ◽  
Author(s):  
T.S. Dharmarajan ◽  
T.S. Dharmarajan ◽  
Komali Kanagala ◽  
A. Lebelt
Keyword(s):  
Urinary Dysfunction ◽  
Anticholinergic Effect

scholarly journals Antipsychotic-induced urinary dysfunction: anticholinergic effect or otherwise?

2009 ◽  
Vol 2009 (may21 1) ◽  
pp. bcr0220091547-bcr0220091547 ◽  
Author(s):  
S. Saddichha ◽  
M. Kumar
Keyword(s):  
Urinary Dysfunction ◽  
Anticholinergic Effect

Anticholinergic effect of Carum copticum on intestinal motility of rats

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
SH Hejazian ◽  
M Mahdavi ◽  
MH Dashti
Keyword(s):  
Intestinal Motility ◽  
Anticholinergic Effect ◽  
Carum Copticum

Psychogenic Urinary Dysfunction in Children and Adults

2012 ◽  
Vol 7 (3) ◽  
pp. 242-246 ◽  
Author(s):  
Ryuji Sakakibara ◽  
Fuyuki Tateno ◽  
Yohei Tsuyusaki ◽  
Masahiko Kishi ◽  
Tomoyuki Uchiyama ◽  
...  
Keyword(s):  
Urinary Dysfunction

scholarly journals Urinary dysfunction with detrusor hyperactivity in women with Parkinson's disease cannot be blamed as a factor of worsening motor performance

2013 ◽  
Vol 71 (9A) ◽  
pp. 591-595 ◽  
Author(s):  
Raimundo Nonato Campos-Sousa ◽  
Elizabeth Maria Aparecida Barasnevicius Quagliato ◽  
Kelson James Almeida ◽  
Inacio Augusto Dias de Castro ◽  
Viriato Campelo
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Motor Performance ◽  
Rating Scale ◽  
Clinical Symptoms ◽  
Urinary Dysfunction ◽  
Clinical Aspects ◽  
Yahr Scale ◽  
Disease Rating ◽  
Detrusor Hyperactivity

Introduction Detrusor hyperactivity is the leading cause of urinary dysfunction in Parkinson's disease (PD). There are few studies correlating PD clinical aspects with this autonomic feature. Methods A cohort of 63 women with PD were prospectively examined for assessment of clinical aspects and disease severity using unified Parkinson's disease rating scale and Hoehn-Yahr scale, respectively. The urologic function was evaluated by the urodynamic study. Two groups were categorized at this time - groups with and without detrusor hyperactivity. After seven years, the same parameters were re-evaluated. Results Progression of the disease on mental scores was found in the group with detrusor hyperactivity. On follow-up, clinical symptoms and severity did not show significant worsening between the groups. Conclusion Detrusor hyperactivity is a frequent urodynamic finding in PD, and even though it is associated with dopaminergic dysfunction, it cannot be blamed as a factor of worsening motor performance, but is probably associated with poor cognitive and mental prognosis.

scholarly journals Mast cell function in prostate inflammation, fibrosis, and smooth muscle cell dysfunction

2021 ◽  
Author(s):  
Goutham Pattabiraman ◽  
Ashlee J Bell-Cohn ◽  
Stephen F. Murphy ◽  
Daniel J Mazur ◽  
Anthony J Schaeffer ◽  
...  
Keyword(s):  
Mast Cell ◽  
Smooth Muscle ◽  
Mast Cells ◽  
Cell Activation ◽  
Cell Function ◽  
Critical Role ◽  
Smooth Muscle Contraction ◽  
Urinary Dysfunction ◽  
Mast Cell Activation ◽  
Prostate Inflammation

Intraurethral inoculation of mice with uropathogenic E. coli (CP1) results in prostate inflammation, fibrosis, and urinary dysfunction, recapitulating some but not all of the pathognomonic clinical features associated with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). In both patients with LUTS and in CP1-infected mice, we observed increased numbers and activation of mast cells and elevated levels of prostate fibrosis. Therapeutic inhibition of mast cells using a combination of mast cell stabilizer (MCS), cromolyn sodium, and the histamine 1 receptor antagonist (H1RA), cetirizine di-hydrochloride, in the mouse model resulted in reduced mast cell activation in the prostate and significant alleviation of urinary dysfunction. Treated mice showed reduced prostate fibrosis, less infiltration of immune cells, and decreased inflammation. In addition, as opposed to symptomatic CP1-infected mice, treated mice showed reduced myosin light chain (MLC)-2 phosphorylation, a marker of prostate smooth muscle contraction. These results show that mast cells play a critical role in the pathophysiology of urinary dysfunction and may be an important therapeutic target for men with BPH/LUTS.

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