Relation between functional and cognitive impairments in remitted patients with bipolar disorder and suggestions for trials targeting cognition: An exploratory study

2019 ◽  
Vol 257 ◽  
pp. 382-389 ◽  
Author(s):  
C. Ott ◽  
H. Miné ◽  
J.Z. Petersen ◽  
K. Miskowiak
Keyword(s):  
Bipolar Disorder ◽  
Exploratory Study ◽  
Cognitive Impairments

Assessment of the neuronal underpinnings of cognitive impairment in bipolar disorder with a picture encoding paradigm and methodological lessons learnt

2021 ◽  
pp. 026988112110085
Author(s):  
JZ Petersen ◽  
J Macoveanu ◽  
HL Kjærstad ◽  
GM Knudsen ◽  
LV Kessing ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Neuronal Activity ◽  
Cognitive Impairments ◽  
Hierarchical Cluster ◽  
Small Region ◽  
Middle Temporal Gyrus ◽  
Recall Accuracy ◽  
Fmri Study

Background: Mood disorders are often associated with persistent cognitive impairments. However, pro-cognitive treatments are essentially lacking. This is partially because of poor insight into the neurocircuitry abnormalities underlying these deficits and their change with illness progression. Aims: This functional magnetic resonance imaging (fMRI) study investigates the neuronal underpinnings of cognitive impairments and neuronal change after mood episodes in remitted patients with bipolar disorder (BD) using a hippocampus-based picture encoding paradigm. Methods: Remitted patients with BD ( n=153) and healthy controls ( n=52) were assessed with neuropsychological tests and underwent fMRI while performing a strategic picture encoding task. A subgroup of patients ( n=43) were rescanned after 16 months. We conducted data-driven hierarchical cluster analysis of patients’ neuropsychological data and compared encoding-related neuronal activity between the resulting neurocognitive subgroups. For patients with follow-up data, effects of mood episodes were assessed by comparing encoding-related neuronal activity change in BD patients with and without episode(s). Results: Two neurocognitive subgroups were revealed: 91 patients displayed cognitive impairments while 62 patients were cognitively normal. No neuronal activity differences were observed between neurocognitive subgroups within the dorsal cognitive control network or hippocampus. However, exploratory whole-brain analysis revealed lower activity within a small region of middle temporal gyrus in impaired patients, which significantly correlated with poorer neuropsychological performance. No changes were observed in encoding-related neuronal activity or picture recall accuracy with the occurrence of mood episode(s) during the follow-up period. Conclusion: Memory encoding fMRI paradigms may not capture the neuronal underpinnings of cognitive impairment or effects of mood episodes.

Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

Neuron ◽  
2021 ◽  
Author(s):  
Amanda M. Vanderplow ◽  
Andrew L. Eagle ◽  
Bailey A. Kermath ◽  
Kathryn J. Bjornson ◽  
Alfred J. Robison ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairments ◽  
Structure And Function ◽  
Neuronal Structure ◽  
And Function

Sex dependence of brain size and shape in bipolar disorder: an exploratory study

2010 ◽  
Vol 12 (3) ◽  
pp. 306-311 ◽  
Author(s):  
Clare E Mackay ◽  
Elina Roddick ◽  
Thomas R Barrick ◽  
Adrian J Lloyd ◽  
Neil Roberts ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Exploratory Study ◽  
Brain Size ◽  
Size And Shape

P.0278 Structural brain abnormalities associated with cognitive impairments in bipolar disorder

2021 ◽  
Vol 53 ◽  
pp. S201
Author(s):  
J. Macoveanu ◽  
K.O. Freeman ◽  
H.L. Kjærstad ◽  
G.M. Knudsen ◽  
L.V. Kessing ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairments ◽  
Brain Abnormalities ◽  
Structural Brain

‘Like a sieve’: an exploratory study on cognitive impairments in patients with multiple myeloma

2010 ◽  
Vol 19 (6) ◽  
pp. 721-728 ◽  
Author(s):  
B. POTRATA ◽  
J. CAVET ◽  
S. BLAIR ◽  
T. HOWE ◽  
A. MOLASSIOTIS
Keyword(s):  
Multiple Myeloma ◽  
Exploratory Study ◽  
Cognitive Impairments

scholarly journals Cardiorespiratory fitness in outpatients with bipolar disorder versus matched controls: An exploratory study

2016 ◽  
Vol 199 ◽  
pp. 1-5 ◽  
Author(s):  
Davy Vancampfort ◽  
Pascal Sienaert ◽  
Sabine Wyckaert ◽  
Michel Probst ◽  
Amber De Herdt ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cardiorespiratory Fitness ◽  
Exploratory Study

scholarly journals Implications of genetic risk information in families with a high density of bipolar disorder: an exploratory study

2005 ◽  
Vol 60 (1) ◽  
pp. 109-118 ◽  
Author(s):  
Bettina Meiser ◽  
Philip B. Mitchell ◽  
H. McGirr ◽  
M. Van Herten ◽  
Peter R. Schofield
Keyword(s):  
Bipolar Disorder ◽  
Genetic Risk ◽  
Exploratory Study ◽  
Risk Information ◽  
High Density ◽  
Genetic Risk Information

Association of subthreshold manic symptoms and cognitive impairments in euthymic patients with bipolar disorder I

2019 ◽  
Vol 278 ◽  
pp. 303-308
Author(s):  
Xiaofei Zhang ◽  
Xiongchao Cheng ◽  
Jianshan Chen ◽  
Bin Zhang ◽  
Qiuxia Wu ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairments ◽  
Manic Symptoms
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