White matter hyperintensities in young individuals with bipolar disorder or at high genetic risk

2019 ◽  
Vol 245 ◽  
pp. 228-236 ◽  
Author(s):  
Riya Wadhwa ◽  
Wei Wen ◽  
Andrew Frankland ◽  
Vivian Leung ◽  
Carina Sinbandhit ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Genetic Risk ◽  
White Matter Hyperintensities ◽  
High Genetic Risk

White Matter Integrity in Individuals at High Genetic Risk of Bipolar Disorder

2011 ◽  
Vol 70 (4) ◽  
pp. 350-356 ◽  
Author(s):  
Emma Sprooten ◽  
Jessika E. Sussmann ◽  
April Clugston ◽  
Anna Peel ◽  
James McKirdy ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Genetic Risk ◽  
White Matter Integrity ◽  
High Genetic Risk

scholarly journals Interhemispheric white matter integrity in young people with bipolar disorder and at high genetic risk

2016 ◽  
Vol 46 (11) ◽  
pp. 2385-2396 ◽  
Author(s):  
G. Roberts ◽  
W. Wen ◽  
A. Frankland ◽  
T. Perich ◽  
E. Holmes-Preston ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Young People ◽  
Age Of Onset ◽  
Familial Risk ◽  
The Novel ◽  
Course Of Illness ◽  
High Genetic Risk ◽  
History Of ◽  
Recurrent Major Depressive Disorder

BackgroundWhite matter (WM) impairments have been reported in patients with bipolar disorder (BD) and those at high familial risk of developing BD. However, the distribution of these impairments has not been well characterized. Few studies have examined WM integrity in young people early in the course of illness and in individuals at familial risk who have not yet passed the peak age of onset.MethodWM integrity was examined in 63 BD subjects, 150 high-risk (HR) individuals and 111 participants with no family history of mental illness (CON). All subjects were aged 12 to 30 years.ResultsThis young BD group had significantly lower fractional anisotropy within the genu of the corpus callosum (CC) compared with the CON and HR groups. Moreover, the abnormality in the genu of the CC was also present in HR participants with recurrent major depressive disorder (MDD) (n = 16) compared with CON participants.ConclusionsOur findings provide important validation of interhemispheric abnormalities in BD patients. The novel finding in HR subjects with recurrent MDD – a group at particular risk of future hypo/manic episodes – suggests that this may potentially represent a trait marker for BD, though this will need to be confirmed in longitudinal follow-up studies.

scholarly journals Abnormal Temporal Lobe White Matter as a Biomarker for Genetic Risk of Bipolar Disorder

2013 ◽  
Vol 73 (2) ◽  
pp. 177-182 ◽  
Author(s):  
Katie Mahon ◽  
Katherine E. Burdick ◽  
Toshikazu Ikuta ◽  
Raphael J. Braga ◽  
Patricia Gruner ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
Temporal Lobe ◽  
Genetic Risk

scholarly journals White matter hyperintensities in subjects with bipolar disorder

2004 ◽  
Vol 58 (5) ◽  
pp. 516-521 ◽  
Author(s):  
KYUNG HEUP AHN ◽  
IN KYOON LYOO ◽  
HO KYU LEE ◽  
IN CHAN SONG ◽  
JUNG SU OH ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
White Matter Hyperintensities

S29ACCELERATED CORTICAL THINNING AND VOLUME REDUCTION OVER TIME IN YOUNG PEOPLE AT HIGH GENETIC RISK FOR BIPOLAR DISORDER

2019 ◽  
Vol 29 ◽  
pp. S129
Author(s):  
Philip Mitchell ◽  
Gloria Roberts ◽  
Rhoshel K. Lenroot ◽  
Bronwyn Overs ◽  
Janice Fullerton ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Young People ◽  
Genetic Risk ◽  
Volume Reduction ◽  
Cortical Thinning ◽  
High Genetic Risk ◽  
Over Time

Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder

2002 ◽  
Vol 114 (1) ◽  
pp. 51-56 ◽  
Author(s):  
Jay J Pillai ◽  
Lee Friedman ◽  
Traci A Stuve ◽  
Sal Trinidad ◽  
John A Jesberger ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
White Matter ◽  
White Matter Hyperintensities ◽  
Adolescent Patients

784. Structural Dysconnectivity of Key Cognitive and Emotional Hubs in Young People at High Genetic Risk for Bipolar Disorder

2017 ◽  
Vol 81 (10) ◽  
pp. S318-S319 ◽  
Author(s):  
Philip Mitchell ◽  
Michael Breakspear ◽  
Gloria Roberts ◽  
Alistair Perry ◽  
Andrew Frankland ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Young People ◽  
Genetic Risk ◽  
High Genetic Risk
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