Multiple cortical thickness sub-networks and cognitive impairments in first episode, drug naïve patients with late life depression: A graph theory analysis

2018 ◽  
Vol 229 ◽  
pp. 538-545 ◽  
Author(s):  
Jeong-Hyeon Shin ◽  
Yu Hyun Um ◽  
Chang Uk Lee ◽  
Hyun Kook Lim ◽  
Joon-Kyung Seong
Keyword(s):  
Graph Theory ◽  
Cortical Thickness ◽  
Cognitive Impairments ◽  
Late Life ◽  
First Episode ◽  
Late Life Depression ◽  
Theory Analysis ◽  
Drug Naïve ◽  
Graph Theory Analysis

scholarly journals Graph Theory Analysis of Cortical-Subcortical Networks in Late-Life Depression

2014 ◽  
Vol 22 (2) ◽  
pp. 195-206 ◽  
Author(s):  
Olusola Ajilore ◽  
Melissa Lamar ◽  
Alex Leow ◽  
Aifeng Zhang ◽  
Shaolin Yang ◽  
...  
Keyword(s):  
Graph Theory ◽  
Late Life ◽  
Late Life Depression ◽  
Theory Analysis ◽  
Graph Theory Analysis

scholarly journals Graph theory analysis of cortical thickness networks in adolescents with d-transposition of the great arteries

2018 ◽  
Vol 8 (2) ◽  
pp. e00834 ◽  
Author(s):  
Christopher G. Watson ◽  
Christian Stopp ◽  
Jane W. Newburger ◽  
Michael J. Rivkin
Keyword(s):  
Graph Theory ◽  
Cortical Thickness ◽  
Theory Analysis ◽  
Graph Theory Analysis

scholarly journals Dynamic Network Connectivity Reveals Markers of Response to Deep Brain Stimulation in Parkinson’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Chengyuan Wu ◽  
Caio Matias ◽  
Thomas Foltynie ◽  
Patricia Limousin ◽  
Ludvic Zrinzo ◽  
...  
Keyword(s):  
Graph Theory ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Theory Analysis ◽  
Whole Brain ◽  
Network Properties ◽  
Brain States ◽  
Graph Theory Analysis ◽  
Stn Dbs ◽  
Deep Brain

Background: Neuronal loss in Parkinson’s Disease (PD) leads to widespread neural network dysfunction. While graph theory allows for analysis of whole brain networks, patterns of functional connectivity (FC) associated with motor response to deep brain stimulation of the subthalamic nucleus (STN-DBS) have yet to be explored.Objective/Hypothesis: To investigate the distributed network properties associated with STN-DBS in patients with advanced PD.Methods: Eighteen patients underwent 3-Tesla resting state functional MRI (rs-fMRI) prior to STN-DBS. Improvement in UPDRS-III scores following STN-DBS were assessed 1 year after implantation. Independent component analysis (ICA) was applied to extract spatially independent components (ICs) from the rs-fMRI. FC between ICs was calculated across the entire time series and for dynamic brain states. Graph theory analysis was performed to investigate whole brain network topography in static and dynamic states.Results: Dynamic analysis identified two unique brain states: a relative hypoconnected state and a relative hyperconnected state. Time spent in a state, dwell time, and number of transitions were not correlated with DBS response. There were no significant FC findings, but graph theory analysis demonstrated significant relationships with STN-DBS response only during the hypoconnected state – STN-DBS was negatively correlated with network assortativity.Conclusion: Given the widespread effects of dopamine depletion in PD, analysis of whole brain networks is critical to our understanding of the pathophysiology of this disease. Only by leveraging graph theoretical analysis of dynamic FC were we able to isolate a hypoconnected brain state that contained distinct network properties associated with the clinical effects of STN-DBS.

The Cerebrovascular Model of Depression in Late Life

CNS Spectrums ◽  
2002 ◽  
Vol 7 (10) ◽  
pp. 712-715 ◽  
Author(s):  
Jeffrey M. Lyness
Keyword(s):  
Stroke Risk ◽  
Age Of Onset ◽  
Cognitive Impairments ◽  
Late Life ◽  
Executive Dysfunction ◽  
Brain Disease ◽  
Future Research ◽  
Late Life Depression ◽  
Vascular Depression ◽  
Cerebrovascular Risk

ABSTRACTDepression in older people, especially depression with an older age of onset, may be a manifestation of acquired brain disease. The cerebrovascular model of depression, often referred to as “vascular depression,” hypothesizes that otherwise clinically occult small vessel brain disease contribute to the pathogeneses of some late-life depressive conditions. This paper reviews several lines of evidence supporting the cerebrovascular model and addresses the limitations of the existing literature. Several directions for future research are noted, including empirical testing of the notion that cerebrovascular disease might underlie the pathogeneses of depression with prominent executive dysfunction or other cognitive impairments. At this time, there are no specific therapeutic options for patients with suspected vascular depression beyond standard approaches to depression treatments, although education about the possibly greater risks of chronicity should be included in treatment planning. Therapy of cerebrovascular risk factors and stroke-risk reduction are important as consistent with general practice guidelines, although it is not known whether this will reduce the incidence or improve the outcome of late-life depression.

scholarly journals Functional neural networks of honesty and dishonesty in children: Evidence from graph theory analysis

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Xiao Pan Ding ◽  
Si Jia Wu ◽  
Jiangang Liu ◽  
Genyue Fu ◽  
Kang Lee
Keyword(s):  
Neural Networks ◽  
Graph Theory ◽  
Theory Analysis ◽  
Graph Theory Analysis
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