Associations of neurofunctional, morphometric and metabolic abnormalities with clinical symptom severity and recognition deficit in obsessive–compulsive disorder

2018 ◽  
Vol 227 ◽  
pp. 603-612 ◽  
Author(s):  
Chung-Man Moon ◽  
Gwang-Woo Jeong
Keyword(s):  
Clinical Symptom ◽  
Obsessive Compulsive Disorder ◽  
Symptom Severity ◽  
Metabolic Abnormalities ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals MRI-Based Multimodal Approach to the Assessment of Clinical Symptom Severity of Obsessive-Compulsive Disorder

2020 ◽  
Vol 17 (8) ◽  
pp. 777-785
Author(s):  
Shin-Eui Park ◽  
Byeong-Chae Kim ◽  
Jong-Chul Yang ◽  
Gwang-Woo Jeong
Keyword(s):  
Prefrontal Cortex ◽  
Clinical Symptom ◽  
Obsessive Compulsive Disorder ◽  
Symptom Severity ◽  
Anterior Cingulate ◽  
Structural Deformation ◽  
Obsessive Compulsive ◽  
Functional Abnormality ◽  
Compulsive Disorder ◽  
Dorsolateral Prefrontal

Objective This study assessed the associations of the abnormal brain activation and functional connectivity (FC) during memory processing and brain volume alteration in conjunction with psychiatric symptom severity in patients with obsessive-compulsive disorder (OCD).Methods Twenty-OCD patients and 20-healthy controls (HC) underwent T1-weighted and functional imaging underlying explicit memory task.Results In memory encoding, OCD patients showed higher activities in right/left (Rt./Lt.) inferior temporal gyrus (ITG), medial prefrontal cortex (MPFC), dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC), compared with HC. In task-based FC, caudate (Cd) was positively connected with DLPFC and ITG in OCD, while HC showed different connectivities of Cd-ACC and Rt.-Lt. ITG. In memory retrieval, only Cd was activated in OCD patients. Cd was positively connected with DLPFC and vmPFC in OCD, but negatively connected between same brain areas in HC. OCD patients showed increased gray matter (GM) volumes of cerebellum, DLPFC, orbitofrontal cortex (OFC), hippocampus, Cd and ITG, and concurrently, increased white matter volumes of DLPFC. In OCD patients, GM volumes of Cd and OFC were positively correlated with HAMA and Y-BOCS. Functional activity changes of Cd in OCD were positively correlated with Y-BOCS.Conclusion Our findings support to accessing clinical symptom and its severity linked by brain structural deformation and functional abnormality in OCD patients.

scholarly journals Demography and symptom severity of obsessive compulsive disorder in Bangladesh: a cross-sectional observation

2020 ◽  
Vol 30 (2) ◽  
pp. 23-26
Author(s):  
Sultana Algin ◽  
Mohammad Waliul Hasnat Sajib ◽  
SM Yasir Arafat
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Symptom Severity ◽  
Large Scale ◽  
Depressive Disorders ◽  
Obsessive Compulsive ◽  
Cross Sectional ◽  
Compulsive Disorder ◽  
Co Morbidity ◽  
Study Results ◽  
Axis I

Obsessive Compulsive Disorder (OCD) is a common disorder and usually runs a chronic course with waxing and waning course. It leads to pervasive impairments in multiple domains of life. The aim of the study was to assess the demographic characteristics of the OCD patients and symptom severity of this disorder. This was a cross-sectional study done in OCD clinic of outpatient department (OPD) of BSMMU, during the period from May, 2015 to April, 2017. Four hundred patients fulfilling the inclusion and exclusion criteria were selected consecutively. After taking written consent a predetermined questionnaire was filled for each patient through face-to-face interview. Then patients were evaluated covering the following areas: Axis I diagnoses (DSM-IV) and Y-BOCS severity scale. The results showed that, the mean age of the respondents was 26.6 (SD±9.9) years, ranging from 8 to 63 years. According to Y-BOCS symptoms severity used for adult patients found that majority (70%) of the patients had moderate to severe sufferings. Male had co-morbid anxiety disorders (panic disorder, agoraphobia, social phobia) more but female patients were found more depressive disorders. Female had more hypothyroidism, diabetes, skin disorders and hypertension than male. These demographic status, co-morbidity profile and symptoms severity can serve as the baseline data for a country like Bangladesh and further large scale, multi-centered study would better generalize the study results. Bang J Psychiatry December 2016; 30(2): 23-26

scholarly journals Executive functioning in Body Dysmorphic Disorder and Obsessive-Compulsive Disorder

2021 ◽  
Author(s):  
Long Long Chen ◽  
Oskar Flygare ◽  
John Wallert ◽  
Jesper Enander ◽  
Volen Ivanov ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Test Performance ◽  
Symptom Severity ◽  
Body Dysmorphic Disorder ◽  
Spatial Working Memory ◽  
Clinical Severity ◽  
Stop Signal Task ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

Objective: To assess executive functions in patients with Body Dysmorphic Disorder (BDD) and Obsessive-Compulsive Disorder (OCD) compared with healthy controls. Methods: Adults diagnosed with BDD (n=26) or OCD (n=29) according to DSM-5, and healthy controls (n=28) underwent validated and computerized neuropsychological tests; spatial working memory (SWM), Intra- extra dimensional set shifting (IED) and Stop signal task (SST), from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Test performance was compared between groups, and correlated to standardized symptom severity of BDD and OCD. Significance level was set to p<0.05. Results: There were no statistically significant between-group differences on key outcome measures in SWM, IED, or SST. There was a weak positive correlation between symptom severity and test errors on SWM and IED in both OCD and BDD groups; increased clinical severity were associated with more errors in these tests. Further, there was a negative correlation between symptom severity and SST in the BDD group. Conclusions: Patients with BDD or OCD did not differ from healthy control subjects in terms of test performance, however there were several statistically significant correlations between symptom severity and performance in those with BDD or OCD. More studies on EF in BDD and OCD are required to elucidate if there are differences in EF between these two disorders.

Beyond Belief: Incremental Prediction of Obsessive-Compulsive Disorder by Looming Vulnerability Illusions

2007 ◽  
Vol 21 (3) ◽  
pp. 243-256 ◽  
Author(s):  
John H. Riskind ◽  
Neil A. Rector
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Symptom Severity ◽  
Cognitive Vulnerability ◽  
Preliminary Evidence ◽  
The Self ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Compulsive Symptom ◽  
Small Cohort ◽  
Obsessive Compulsive Symptom

Cognitive models argue that obsessions and compulsions arise from distorted beliefs and exaggerated interpretations of intrusive thoughts. While these models have led to important advances, recent research has suggested the need to go beyond the factors the models identify. One new factor to consider may involve looming vulnerability, the production of dynamic mental scenarios of danger outcomes (e.g., contamination, harming, losing wanted possessions) as rushing through time and space and escalating in odds of harm for the self. Looming vulnerability is a different form of cognition that differs from belief factors because it concerns the process of anticipating noxious events as rapidly rising in risk rather than static beliefs about the final end states (e.g., responsibility, perfection). The present study tested looming vulnerability by examining a small cohort of 37 patients with obsessive-compulsive disorder (OCD). Results provide strong preliminary evidence that looming vulnerability in OCD-related themes (e.g., contamination, hoarding, and pure obsessional) contributes significant and substantial variance to the prediction of obsessive compulsive symptom severity on the Yale-Brown Obsessive-Compulsive Scale beyond the effects of beliefs and interpretations. Thus, looming vulnerability may represent a different form of cognitive vulnerability for the development and persistence of clinical obsessions that warrants further investigation.

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