Whole-brain resting-state functional connectivity identified major depressive disorder: A multivariate pattern analysis in two independent samples

2017 ◽  
Vol 218 ◽  
pp. 346-352 ◽  
Author(s):  
Xue Zhong ◽  
Huqing Shi ◽  
Qingsen Ming ◽  
Daifeng Dong ◽  
Xiaocui Zhang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Resting State ◽  
Pattern Analysis ◽  
Multivariate Pattern Analysis ◽  
Resting State Functional Connectivity ◽  
Major Depressive ◽  
Whole Brain ◽  
Multivariate Pattern

Local cortical thinning links to resting-state disconnectivity in major depressive disorder

2013 ◽  
Vol 44 (10) ◽  
pp. 2053-2065 ◽  
Author(s):  
M.-J. van Tol ◽  
M. Li ◽  
C. D. Metzger ◽  
N. Hailla ◽  
D. I. Horn ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Cortical Thickness ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Major Depressive ◽  
Cross Sectional ◽  
Whole Brain ◽  
Tissue Abnormalities

BackgroundLocal structural and metabolic as well as inter-regional connectivity abnormalities have been implicated in the neuropathology of major depressive disorder (MDD). How local tissue properties affect intrinsic functional connectivity is, however, unclear. Using a cross-sectional, multi-modal imaging approach, we investigated the relationship between local cortical tissue abnormalities and intrinsic resting-state functional connectivity (RSFC) in MDD.MethodA total of 20 MDD in-patients and 20 healthy controls underwent magnetic resonance imaging at 3 T for structural and functional imaging. Whole-brain cortical thickness was calculated and compared between groups. Regions with reduced cortical thickness defined seeds for subsequent whole-brain RSFC analyses. Contributions of structural tissue abnormalities on inter-regional RSFC were explicitly investigated.ResultsLower cortical thickness was observed in MDD in the right dorsomedial prefrontal cortex (PFC), superior temporal gyrus/temporal pole, middle-posterior cingulate cortex, and dorsolateral PFC. No differences in local fractional amplitude of low-frequency fluctuations were observed. Lower thickness in patients' dorsomedial PFC further directly and selectively affected its RSFC with the precuneus, which was unaffected by symptom severity. No effects of cortical thickness in other regions showing abnormal thickness were observed to influence functional connectivity.ConclusionsAbnormal cortical thickness in the dorsomedial PFC in MDD patients was observed to selectively and directly affect its intrinsic connectivity with the precuneus in MDD patients independent of depression severity, thereby marking a potential vulnerability for maladaptive mood regulation. Future studies should include an unmedicated sample and replicate findings using independent component analysis to test for morphometric effects on network integrity.

Resting-state functional connectivity in major depressive disorder: A review

2015 ◽  
Vol 56 ◽  
pp. 330-344 ◽  
Author(s):  
Peter C. Mulders ◽  
Philip F. van Eijndhoven ◽  
Aart H. Schene ◽  
Christian F. Beckmann ◽  
Indira Tendolkar
Keyword(s):  
Major Depressive Disorder ◽  
Functional Connectivity ◽  
Depressive Disorder ◽  
Resting State ◽  
Resting State Functional Connectivity ◽  
Major Depressive
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