Assessment of abnormal brain structures and networks in major depressive disorder using morphometric and connectome analyses

2016 ◽  
Vol 205 ◽  
pp. 103-111 ◽  
Author(s):  
Vincent Chin-Hung Chen ◽  
Chao-Yu Shen ◽  
Sophie Hsin-Yi Liang ◽  
Zhen-Hui Li ◽  
Yeu-Sheng Tyan ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Brain Structures ◽  
Major Depressive ◽  
Abnormal Brain

Altered Brain Network Degree Centrality in Major Depressive Disorder via Electro-Acupuncture Stimulation at Baihui(gv20)

2021 ◽  
Author(s):  
Shasha Li ◽  
Ya Chen ◽  
Gaoxiong Duan ◽  
Yong Pang ◽  
Huimei Liu ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Brain Function ◽  
Brain Regions ◽  
Brain Network ◽  
Degree Centrality ◽  
Major Depressive ◽  
Acupuncture Stimulation ◽  
Therapeutic Mechanisms ◽  
Abnormal Brain

Abstract Background: Although the acupuncture treatment of major depressive disorder(MDD) has been recognized by the latest clinical practice guidelines of the American Academy of Internal Medicine, complex therapeutic mechanisms need further to clarify. The aim of the study is investigate whether the aberrant resting state brain network in MDD patients could be regulated by acupuncture at GV20 using functional magnetic resonance imaging(fMRI) combined with degree centrality(DC) method. Results: Compared to healthy subjects, MDD patients exhibited significantly aberrant DC in widely brain regions, including cortical(PFC, precuneus, temporal, insula) and sub-cortical (thalamus, putamen and caudate) structures. Furthermore, results showed that acupuncture at GV20 induced down-regulation the DC of abnormal brain regions in MDD patients. Conclusions: Our findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the abnormal brain function state in MDD patients by using fMRI technique combined with DC analysis. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical. Trial registration: ChiCTR, ChiCTR-IOR-15006357. Registered 05 May 2015, http://www.chictr.org.cn/showproj.aspx?proj=10922.

Joint source based analysis of multiple brain structures in studying major depressive disorder

2014 ◽  
Author(s):  
Mahdi Ramezani ◽  
Abtin Rasoulian ◽  
Tom Hollenstein ◽  
Kate Harkness ◽  
Ingrid Johnsrude ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Brain Structures ◽  
Major Depressive
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