scholarly journals Alterations in regional homogeneity of resting-state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32)

2016 ◽  
Vol 203 ◽  
pp. 69-76 ◽  
Author(s):  
Haichen Yang ◽  
Linling Li ◽  
Hongjun Peng ◽  
Tiebang Liu ◽  
Allan H. Young ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Resting State ◽  
Brain Activity ◽  
Regional Homogeneity ◽  
Major Depressive

scholarly journals Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Lingling Cui ◽  
Xiaohong Gong ◽  
Yanqing Tang ◽  
Lingtao Kong ◽  
Miao Chang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Prefrontal Cortex ◽  
Depressive Disorder ◽  
Resting State ◽  
Brain Activity ◽  
Association Studies ◽  
Neural System ◽  
Middle Temporal Gyrus ◽  
Genome Wide Association Studies ◽  
Major Depressive

A single-nucleotide polymorphism at the LHPP gene (rs35936514) has been reported in genome-wide association studies to be associated with major depressive disorder (MDD). However, the neural system effects of rs35936514 that mediate the association are unknown. The present work explores whether the LHPP rs35936514 polymorphism moderates brain regional activity in MDD. A total of 160 subjects were studied: a CC group homozygous for the C allele (23 individuals with MDD and 57 controls) and a T-carrier group carrying the high risk T allele (CT/TT genotypes; 22 MDD and 58 controls). All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning. Brain activity was assessed using the amplitudes of low-frequency fluctuations (ALFF). MDD patients showed a significant increased ALFF in the left middle temporal gyrus and occipital cortex. The T-carrier group showed increased ALFF in the left superior temporal gyrus. Significant diagnosis × genotype interaction was noted in the bilateral lingual gyri, bilateral dorsal lateral prefrontal cortex (dlPFC), and left medial prefrontal cortex (mPFC) (P<0.05, corrected). Results demonstrated that MDD patients with LHPP rs35936514 CT/TT genotype may influence the regional brain activity. These findings implicate the effects of the rs35936514 variation on the neural system in MDD.

Resting-state brain activity in major depressive disorder patients and their siblings

2013 ◽  
Vol 149 (1-3) ◽  
pp. 299-306 ◽  
Author(s):  
Chun-Hong Liu ◽  
Xin Ma ◽  
Xia Wu ◽  
Ting-Ting Fan ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Resting State ◽  
Brain Activity ◽  
Major Depressive

scholarly journals Amygdala and whole-brain activity to emotional faces distinguishes major depressive disorder and bipolar disorder

2013 ◽  
Vol 15 (7) ◽  
pp. 741-752 ◽  
Author(s):  
Jay C Fournier ◽  
Matthew T Keener ◽  
Jorge Almeida ◽  
Dina M Kronhaus ◽  
Mary L Phillips
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Brain Activity ◽  
Major Depressive ◽  
Whole Brain ◽  
Emotional Faces
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