Taxonicity and network structure of generalized anxiety disorder and major depressive disorder: An admixture analysis and complex network analysis

2016 ◽  
Vol 199 ◽  
pp. 99-105 ◽  
Author(s):  
Joshua Curtiss ◽  
David H. Klemanski
Keyword(s):  
Major Depressive Disorder ◽  
Anxiety Disorder ◽  
Network Analysis ◽  
Depressive Disorder ◽  
Complex Network ◽  
Generalized Anxiety Disorder ◽  
Network Structure ◽  
Generalized Anxiety ◽  
Admixture Analysis ◽  
Major Depressive

scholarly journals The network structure of major depressive disorder, generalized anxiety disorder and somatic symptomatology

2016 ◽  
Vol 46 (14) ◽  
pp. 2989-2998 ◽  
Author(s):  
E. Bekhuis ◽  
R. A. Schoevers ◽  
C. D. van Borkulo ◽  
J. G. M. Rosmalen ◽  
L. Boschloo
Keyword(s):  
Major Depressive Disorder ◽  
Anxiety Disorder ◽  
Depressive Disorder ◽  
Generalized Anxiety Disorder ◽  
Network Structure ◽  
Depressive Symptomatology ◽  
Somatic Symptoms ◽  
Future Research ◽  
Generalized Anxiety ◽  
Major Depressive

BackgroundMajor depressive disorder (MDD) and generalized anxiety disorder (GAD) often co-occur with somatic symptomatology. Little is known about the contributions of individual symptoms to this association and more insight into their relationships could help to identify symptoms that are central in the processes behind the co-occurrence. This study explores associations between individual MDD/GAD symptoms and somatic symptoms by using the network approach.MethodMDD/GAD symptoms were assessed in 2704 participants (mean age 41.7 years, 66.1% female) from the Netherlands Study of Depression and Anxiety using the Inventory of Depressive Symptomatology. Somatic symptoms were assessed with the somatization scale of the Four-Dimensional Symptom Questionnaire. The technique eLasso was used to estimate the network of MDD/GAD and somatic symptoms.ResultsThe network structure showed numerous associations between MDD/GAD and somatic symptoms. In general, neurovegetative and cognitive/affective MDD/GAD symptoms showed a similar strength of connections to the somatic domain. However, associations varied substantially across individual symptoms. MDD/GAD symptoms with many and strong associations to the somatic domain included anxiety and fatigue, whereas hypersomnia and insomnia showed no connections to somatic symptoms. Among somatic symptoms, excessive perspiration and pressure/tight feeling in chest were associated with the MDD/GAD domain, while muscle pain and tingling in fingers showed only a few weak associations.ConclusionsIndividual symptoms show differential associations in the co-occurrence of MDD/GAD with somatic symptomatology. Strongly interconnected symptoms are important in furthering our understanding of the interaction between the symptom domains, and may be valuable targets for future research and treatment.

scholarly journals Disorder-specific cognitive profiles in major depressive disorder and generalized anxiety disorder

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Sanne M Hendriks ◽  
Carmilla MM Licht ◽  
Jan Spijker ◽  
Aartjan TF Beekman ◽  
Florian Hardeveld ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Anxiety Disorder ◽  
Depressive Disorder ◽  
Generalized Anxiety Disorder ◽  
Generalized Anxiety ◽  
Cognitive Profiles ◽  
Major Depressive

scholarly journals An Underlying Common Factor, Influenced by Genetics and Unique Environment, Explains the Covariation Between Major Depressive Disorder, Generalized Anxiety Disorder, and Burnout: A Swedish Twin Study

2016 ◽  
Vol 19 (6) ◽  
pp. 619-627 ◽  
Author(s):  
Lisa Mather ◽  
Victoria Blom ◽  
Gunnar Bergström ◽  
Pia Svedberg
Keyword(s):  
Risk Factors ◽  
Major Depressive Disorder ◽  
Anxiety Disorder ◽  
Environmental Factors ◽  
Depressive Disorder ◽  
Generalized Anxiety Disorder ◽  
Common Factor ◽  
Generalized Anxiety ◽  
Major Depressive ◽  
Common Pathway

Depression and anxiety are highly comorbid due to shared genetic risk factors, but less is known about whether burnout shares these risk factors. We aimed to examine whether the covariation between major depressive disorder (MDD), generalized anxiety disorder (GAD), and burnout is explained by common genetic and/or environmental factors. This cross-sectional study included 25,378 Swedish twins responding to a survey in 2005–2006. Structural equation models were used to analyze whether the trait variances and covariances were due to additive genetics, non-additive genetics, shared environment, and unique environment. Univariate analyses tested sex limitation models and multivariate analysis tested Cholesky, independent pathway, and common pathway models. The phenotypic correlations were 0.71 (0.69–0.74) between MDD and GAD, 0.58 (0.56–0.60) between MDD and burnout, and 0.53 (0.50–0.56) between GAD and burnout. Heritabilities were 45% for MDD, 49% for GAD, and 38% for burnout; no statistically significant sex differences were found. A common pathway model was chosen as the final model. The common factor was influenced by genetics (58%) and unique environment (42%), and explained 77% of the variation in MDD, 69% in GAD, and 44% in burnout. GAD and burnout had additive genetic factors unique to the phenotypes (11% each), while MDD did not. Unique environment explained 23% of the variability in MDD, 20% in GAD, and 45% in burnout. In conclusion, the covariation was explained by an underlying common factor, largely influenced by genetics. Burnout was to a large degree influenced by unique environmental factors not shared with MDD and GAD.

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