Admixture analysis of age at onset in first episode bipolar disorder

2016 ◽  
Vol 201 ◽  
pp. 88-94 ◽  
Author(s):  
Behdin Nowrouzi ◽  
Roger S. McIntyre ◽  
Glenda MacQueen ◽  
Sidney H. Kennedy ◽  
James L. Kennedy ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Age At Onset ◽  
First Episode ◽  
Admixture Analysis

Using admixture analysis to examine birth-cohort effects on age at onset of bipolar disorder

2015 ◽  
Vol 133 (3) ◽  
pp. 205-213 ◽  
Author(s):  
J.-L. Golmard ◽  
J. Scott ◽  
B. Etain ◽  
M. Preisig ◽  
J.-M. Aubry ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Birth Cohort ◽  
Age At Onset ◽  
Cohort Effects ◽  
Admixture Analysis

Incidence and distribution of first-episode mania by age: results from a 35-year study

2004 ◽  
Vol 35 (6) ◽  
pp. 855-863 ◽  
Author(s):  
N. KENNEDY ◽  
B. EVERITT ◽  
J. BOYDELL ◽  
J. VAN OS ◽  
P. B. JONES ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Age At Onset ◽  
Adult Life ◽  
Mixture Distribution ◽  
Manic Episode ◽  
Incidence Rates ◽  
First Episode ◽  
Normal Mixture ◽  
Component Mixture ◽  
Early Adult Life

Background. Few epidemiological studies have investigated incidence by age or age at onset distributions for mania or bipolar disorder. The current study aimed to determine these in a defined area in south-east London, over a 35-year period.Method. All cases of first-episode mania presenting to psychiatric services in Camberwell, south-east London, between 1965 and 1999 were identified. Incidence rates by age, using 5-year age-at-onset bands, were estimated and the structure of the age-at-onset distribution for first-episode mania was investigated using finite mixture distributions (admixture analysis).Results. The incidence of DSM-IV bipolar I disorder (BP I), first manic episode peaked in early adult life (16·38/100000 population per year in the 21–25 years band) with a much smaller peak in mid-life. A two-component normal mixture distribution fitted age at onset better than either a single normal distribution or a three-component mixture, implying the existence of early and later onset subgroups. The early onset group had a stronger family history of bipolar disorder, and showed more acute, severe and atypical symptoms during their first manic episode.Conclusions. The incidence of mania peaks in early adult life but there is clear evidence of early and later onset subgroups which may represent different forms of disorder.

Admixture analysis of age at onset in schizophrenia: evidence of three subgroups in a first-episode sample

2013 ◽  
Vol 35 (6) ◽  
pp. 664-667 ◽  
Author(s):  
Jerome J. Liu ◽  
Ross M.G. Norman ◽  
Raul Manchanda ◽  
Vincenzo De Luca
Keyword(s):  
Age At Onset ◽  
First Episode ◽  
Admixture Analysis

Admixture analysis of age at onset in bipolar disorder

2011 ◽  
Vol 185 (1-2) ◽  
pp. 27-32 ◽  
Author(s):  
Federica Tozzi ◽  
Mirko Manchia ◽  
Nicholas W. Galwey ◽  
Giovanni Severino ◽  
Maria Del Zompo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Age At Onset ◽  
Admixture Analysis

Misdiagnosis and psychotic symptoms in bipolar disorder

2011 ◽  
Vol 26 (S2) ◽  
pp. 255-255
Author(s):  
A. Ugarte ◽  
M. Fernández ◽  
I. González ◽  
J.R. Peciña ◽  
A. Villamor ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Basque Country ◽  
Correct Diagnosis ◽  
Age At Onset ◽  
Mood Stabilizers ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Psychotic Episode ◽  
Diagnostic Systems ◽  
Bipolar Patients

IntroductionEarly onset forms of bipolar disorder may be difficult to distinguish from schizophrenia. Although operational criteria have become more precise, and there are more diagnostic systems to catalogue a psychotic adolescent, the clinicians continue having difficulties.ObjectiveTo know the stability of the diagnosis of definitively bipolar patients with psychotic symptoms during the episodes, and factors that can influence other psychotic diagnoses in the first episode of the illness.Method140 bipolar patients of Araba, (Basque country) were included during 2 years. Patients were divided into two groups: unstable diagnoses (UD)(bipolar patients with an initial diagnosis of other psychosis) and stable diagnoses (SD) of bipolar disorder. Clinical and sociodemographic data were obtained.ResultsThe mean age at onset was significantly lower in the UD group (p = 0.004). It was rare to have an unstable diagnosis when the first psychotic episode occurred after age 38 (p = 0.008). There were more singles in the UD group (p = 0.010).The presence of mood incongruent psychotic symptoms was more frequent in the UD group (p < 0.001).Mood incongruent psychotic symptoms variable was the only independent factor significantly associated with an unstable diagnosis in the multivariate analysis (p = 0.036).DiscussionOne third of the patients have been previously diagnosed with other psychotic illness.This study suggests that the most important factor is the clinical picture, especially the presence of mood-incongruent psychotic symptoms. A correct diagnosis is important because patients who are prescribed mood stabilizers have lower rates of rehospitalisation than those who are not treated with mood stabilizers.

scholarly journals Age at onset of first episode and time to treatment in in-patients with bipolar disorder

2009 ◽  
Vol 194 (6) ◽  
pp. 559-560 ◽  
Author(s):  
Gunnar Morken ◽  
Arne E. Vaaler ◽  
Gunn E. Folden ◽  
Ole A. Andreassen ◽  
Ulrik F. Malt
Keyword(s):  
Bipolar Disorder ◽  
Pharmacological Treatment ◽  
Similar Pattern ◽  
Catchment Area ◽  
Age At Onset ◽  
Age Groups ◽  
First Episode ◽  
Early Age ◽  
The Usa ◽  
The Relationship

SummaryThis study aimed to investigate the relationship between age at onset and time to first pharmacological treatment in patients with either bipolar I or II disorder. A total of 146 consecutive in-patients acutely admitted from the same catchment area were included. Patients were divided into four age groups: 0–12 years (23%); 13–18 years (32%); 19–29 years (26%); and 30 years (18%). Mean age at first affective episode was 20.2 years (s.d.=11.8). This represents a similar pattern to the age at onset seen in out-patients in the USA. Early age at onset predicted a longer time to first pharmacological treatment (ρ =0.695, P <0.01).

Factors associated with borderline personality disorder in major depressive patients and their relationship to bipolarity

2013 ◽  
Vol 28 (8) ◽  
pp. 463-468 ◽  
Author(s):  
J.M. Azorin ◽  
A. Kaladjian ◽  
M. Adida ◽  
E. Fakra ◽  
R. Belzeaux ◽  
...  
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Age At Onset ◽  
Borderline Personality ◽  
First Episode ◽  
Contributory Factor ◽  
Structured Interviews ◽  
Major Depressive ◽  
History Of ◽  
Depressive Patients

AbstractObjectiveTo analyze the interface between borderline personality disorder (BPD) and bipolarity in depressed patients comorbid with BPD.MethodsAs part of National Multi-site Study of 493 consecutive DSM-IV major depressive patients evaluated in at least two semi-structured interviews 1 month apart, 19 (3.9%) had comorbid BPD (BPD+), whereas 474 (96.1%) did not manifest this comorbidity (BPD−).ResultsCompared to BPD (−), BPD (+) patients displayed higher rates of bipolar (BP) disorders and temperaments, an earlier age at onset with a family history of affective illness, more comorbidity, more stressors before the first episode which was more often depressive or mixed, as well as a greater number and severity of affective episodes.ConclusionsThe hypothesis which fitted at best our findings was to consider BPD as a contributory factor in the development of BP disorder, which could have favoured the progression from unipolar major depression to BP disorder. We could not however exclude that some features of BP disorder may have contributed to the development of BPD.

scholarly journals Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder

2011 ◽  
Vol 156 (3) ◽  
pp. 370-378 ◽  
Author(s):  
Pamela Belmonte Mahon ◽  
Mehdi Pirooznia ◽  
Fernando S. Goes ◽  
Fayaz Seifuddin ◽  
Jo Steele ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Analysis ◽  
Age At Onset ◽  
Genome Wide Association ◽  
Psychotic Symptoms ◽  
Genome Wide Association Analysis ◽  
Genome Wide

Phenomenology associated with age at onset in patients with bipolar disorder at their first psychiatric hospitalization

2006 ◽  
Vol 8 (1) ◽  
pp. 91-94 ◽  
Author(s):  
Nick C Patel ◽  
Melissa P DelBello ◽  
Paul E Keck ◽  
Stephen M Strakowski
Keyword(s):  
Bipolar Disorder ◽  
Psychiatric Hospitalization ◽  
Age At Onset

Lymphopaenia as a predictor of sarcoidosis in patients with a first episode of uveitis

2018 ◽  
Vol 103 (9) ◽  
pp. 1296-1300 ◽  
Author(s):  
Fahriye Groen-Hakan ◽  
Laura Eurelings ◽  
Aniki Rothova ◽  
Jan van Laar
Keyword(s):  
Diagnostic Tests ◽  
Medical Center ◽  
Age At Onset ◽  
Diagnostic Value ◽  
Youden Index ◽  
First Episode ◽  
Operating Characteristics ◽  
Non Invasive ◽  
Erasmus Medical ◽  
Uveitis Attack

Background/aimsThe diagnostic properties of conventional diagnostic tests (ACE and chest radiography) for sarcoidosis-associated uveitis are not ideal. The diagnostic value of lymphopaenia for sarcoidosis-associated uveitis is investigated.MethodsA retrospective study of 191 consecutive patients with a first uveitis episode visiting the ophthalmology department (Erasmus Medical Center, Rotterdam, The Netherlands). Receiver operating characteristics (ROC) analysis was performed and compared with known ROC values from literature of conventional diagnostic tests for sarcoidosis-associated uveitis. An ideal cut-off was determined for lymphopaenia by calculation of the highest Youden index.ResultsOut of all patients with first uveitis attack, 32/191 or 17% were subsequently diagnosed with biopsy-proven or radiological diagnosis of sarcoidosis. Lymphopaenia (<1.5×109/L) was significantly more often observed in patients with sarcoidosis-associated uveitis compared with patients with non-sarcoidosis-associated uveitis (p<0.05). The sensitivity and specificity of lymphopaenia was 75 % and 77 %, respectively. The optimal cut-off for lymphopaenia for diagnosing sarcoidosis-associated uveitis was 1.47 ×109/L. Lymphopaenia resulted in a 12.0 (95% CI 4.7 to 30.5 fold risk for having sarcoidosis, corrected for sex, race and age at onset of uveitis in patients with a first uveitis attack.ConclusionLymphopaenia is a non-invasive and useful marker for diagnosing sarcoidosis-associated uveitis.

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