Association of inflammatory biomarkers with depressive symptoms and cognitive decline in a community-dwelling healthy older sample: A 3-year follow-up study

2015 ◽  
Vol 173 ◽  
pp. 9-14 ◽  
Author(s):  
Jun Matsushima ◽  
Toshiro Kawashima ◽  
Hiromi Nabeta ◽  
Yoshiomi Imamura ◽  
Itaru Watanabe ◽  
...  
2015 ◽  
Vol 22 (6) ◽  
pp. 637-644 ◽  
Author(s):  
Taiki Yukutake ◽  
Minoru Yamada ◽  
Naoto Fukutani ◽  
Shu Nishiguchi ◽  
Hiroki Kayama ◽  
...  

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S166-S166
Author(s):  
Randolph Chan ◽  
Jennifer Y M Tang ◽  
Tianyin Liu ◽  
Gloria H Y Wong

Abstract Background and Objectives: The relationship between objective and subjective cognitive function and depressive symptoms is complex and potentially multidirectional. This longitudinal prospective study examined the directionality of their relationship among a community sample of older people with no known diagnosis or treatment for dementia or depression. Research Design and Methods: We examined the temporal relationship between objective cognitive functioning, subjective cognitive complaints, and depressive symptoms in 1,814 community-dwelling older people at baseline and one-year follow-up using regression and two-wave cross-lagged panel analyses, after controlling for demographic and health confounders. Results: Cross-lagged analysis showed that depressive symptoms at follow-up were directly predicted by baseline subjective cognitive complaints, but not baseline objective cognitive functioning. The effect differed across objective cognitive functioning levels. In people with clinically significant cognitive impairment at baseline, objective cognitive decline but not baseline subjective cognitive complaints predicted depressive symptoms. In people with mild objective cognitive impairment at baseline, baseline subjective complaints but not objective cognitive decline predicted depressive symptoms. Discussion and Implications: The effects of objective and subjective cognitive decline on depressive symptoms varied across older people with different levels of cognitive impairment. Awareness and insight of one’s cognitive status may contribute to the development/progression in depressive symptom in people with mild cognitive impairment. Mechanisms unrelated to appraisal may be involved in increased depressive symptoms among older persons with significant objective cognitive impairment.


2018 ◽  
Vol 110 ◽  
pp. 241-246 ◽  
Author(s):  
André Bonadias Gadelha ◽  
Silvia Gonçalves Ricci Neri ◽  
Martim Bottaro ◽  
Ricardo M. Lima

2014 ◽  
Vol 22 (9) ◽  
pp. 917-925 ◽  
Author(s):  
Rebecca S. Hock ◽  
Hochang Benjamin Lee ◽  
O. Joseph Bienvenu ◽  
Gerald Nestadt ◽  
Jack F. Samuels ◽  
...  

Radiology ◽  
2017 ◽  
Vol 282 (2) ◽  
pp. 526-533 ◽  
Author(s):  
Quirijn J. A. van den Bouwhuijsen ◽  
Mariana Selwaness ◽  
Hui Tang ◽  
Wiro J. Niessen ◽  
Albert Hofman ◽  
...  

2016 ◽  
Vol 69 (4) ◽  
pp. 691-696 ◽  
Author(s):  
Suzele Cristina Coelho Fabrício-Wehbe ◽  
Rosalina Aparecida Partezani Rodrigues ◽  
Vanderlei Jose Haas ◽  
Jack Roberto Silva Fhon ◽  
Marina Aleixo Diniz

ABSTRACT Objective: to investigate the association between frailty with hospitalization and institutionalization in a follow-up study of elderly residents. Method: the follow-up study was performed in 2008 and 2013 with elderly of both genders, aged 65 years and older who were living in the community-dwelling. The sampling procedure performed was probabilistic, with dual-stage clustering. In 2008, 515 elderly people were interviewed and, in 2013, 262. We used the socioeconomic and demographic data, self-reported morbidity, specific data of hospitalization and institutionalization. Frailty was measured by the Edmonton Frail Scale (EFS), and functional capacity through the Functional Independence Measure. Results: we found the mean gross EFS score was higher among resident elderly who were hospitalized and institutionalized and was statistically significant in both investigated years. Conclusion: the confirmation of association between frailty and hospitalization and institutionalization reinforces the importance of the subject, and highlights frailty as an important tool for risk estimates for these adverse events.


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