An investigation into the relationship between first-degree relatives of bipolar affective disorder and (idiopathic) epilepsy in a sub-Saharan African population

2014 ◽  
Vol 161 ◽  
pp. 84-86 ◽  
Author(s):  
M.S. Jidda ◽  
M.A. Wakil ◽  
A.W. Ibrahim ◽  
A.O. Mohammed
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
African Population ◽  
Idiopathic Epilepsy ◽  
First Degree Relatives ◽  
Sub Saharan ◽  
The Relationship

scholarly journals Cigarette smoking and psychotic symptoms in bipolar affective disorder

2001 ◽  
Vol 179 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Aiden Corvin ◽  
Ed O'Mahony ◽  
Myra O'Regan ◽  
Claire Comerford ◽  
Robert O'Connell ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Psychotic Symptoms ◽  
Heavy Smoking ◽  
Ordinal Logistic Regression Analysis ◽  
History Of ◽  
Categorical Diagnosis ◽  
The Relationship

BackgroundAn association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology.AimsTo determine whether smoking is associated with psychosis in bipolar affective disorder.MethodSmoking data were collected from 92 unrelated patients with bipolar affective disorder. An ordinal logistic regression analysis tested the relationship between smoking severity and psychotic symptomatology, allowing for potential confounders.ResultsA significant relationship was detected between smoking/heavy smoking and history of psychosis (68.7%, n=44). Smoking was less prevalent in patients who were less symptomatic (56.5%, n=13) than in patients with a more severe psychosis (75.7%, n=31). Prevalence and severity of smoking predicted severity of psychotic symptoms (P=0.001), a relationship independent of other variables (P=0.0272).ConclusionA link between smoking and psychosis exists in bipolar affective disorder and may be independent of categorical diagnosis.

scholarly journals Impulsivity as a Clinical Marker for Bipolar Affective Disorder

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
A M Omar ◽  
A N Elbatrawy ◽  
W M Sabry ◽  
H A Elkholy ◽  
W A Farrag
Keyword(s):  
Bipolar Disorder ◽  
Affective Disorder ◽  
Behavioral Problems ◽  
Psychosocial Functioning ◽  
Bipolar Affective Disorder ◽  
Bipolar Disorders ◽  
First Degree Relatives ◽  
Adult Psychiatry ◽  
Healthy Functioning ◽  
Substantial Morbidity

Abstract Background Bipolar disorder is one of the world’s 10 most disabling conditions, taking away years of healthy functioning from individuals, all bipolar disorders are chronically recurring illnesses associated with substantial morbidity and mortality. Impulsivity considered an integral part of bipolar disorder. Operationalized as a predisposition to action without reflection or regard for consequences. Potential consequences of this increased impulsivity include substance abuse, suicidal attempts, and other serious behavioral problems. Aim of the Study The aim of the current study was to measure impulsivity in both BD euthymic patients and in healthy first-degree relatives of BD patients. And to assess the functional implications of impulsiveness, on psychosocial functioning and in bipolar disorder patients, their first-degree relatives. Patients and Methods A convenient sample of 50 patients; diagnosed with bipolar affective disorder according to DSM-IV diagnostic criteria were selected from the general adult psychiatry clinics and a convenient sample of 50 healthy first degree relatives of BD patients. Results We concluded by the end of this study that both cases and relatives have high overall impulsivity, and cases have higher impulsivity in comparison to relatives. Conclusion We suggest that impulsivity may be a potentially valuable candidate endophenotype for bipolar disorder.

A Genetic Study of Bipolar Affective Disorder

1975 ◽  
Vol 126 (5) ◽  
pp. 449-456 ◽  
Author(s):  
N. MeI. James ◽  
C. J. Chapman
Keyword(s):  
Mental Disorder ◽  
Affective Disorder ◽  
Assortative Mating ◽  
Genetic Study ◽  
Bipolar Affective Disorder ◽  
High Rate ◽  
Polygenic Inheritance ◽  
First Degree Relatives

SummaryA group of 46 bipolar probands and their first degree relatives were studied. A high rate of affective disorder (19.6 per cent) was found, including both unipolar (13.2 per cent) and bipolar (6.4 per cent) types, with females predominating (3: 1). The presence of four father-son pairs suffering from affective disorder made the hypothesis of X-linked dominance untenable. Results compatible with polygenic inheritance were found, using both Slater's and Falconer's methods. There was no evidence for assortative mating or for increased total number of females (both well and ill) among first degree relatives. The probands and affectively ill first degree relatives who have died show an alarmingly high rate of suicide (46 per cent). Other forms of mental disorder, including alcoholism, were no more common than in the rest of the community.

Bipolar affective disorder as the initial manifestation of multiple sclerosis

2010 ◽  
Vol 27 (2) ◽  
pp. 97-98
Author(s):  
Adarsh Vohra ◽  
Caroline Leeming
Keyword(s):  
Multiple Sclerosis ◽  
Differential Diagnosis ◽  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
Neurological Symptoms ◽  
Pertinent Literature ◽  
Initial Manifestation ◽  
Limited Knowledge ◽  
The Relationship

AbstractThe association between bipolar affective disorder and multiple sclerosis continues to be poorly understood in view of the limited knowledge and research in this field. Here we present the case of a 43 year old female with bipolar affective disorder who later developed multiple sclerosis. The relationship between the two disorders is discussed in the light of relevant and pertinent literature. It is hypothesised that bipolar affective disorder may be the presenting manifestation of multiple sclerosis and should be considered as a differential diagnosis in patients of bipolar affective disorder with neurological symptoms.

Current Approaches to Diagnostics of Bipolar Affective Disorder in Adolescents

2020 ◽  
pp. 69-78
Author(s):  
Leonid Bardenshtein ◽  
Natalia Osipova
Keyword(s):  
Affective Disorder ◽  
Bipolar Affective Disorder ◽  
International Classification Of Diseases ◽  
Diagnostic Systems ◽  
Dsm V ◽  
Screening Study ◽  
Classification Of Diseases ◽  
Research Findings ◽  
The Relationship

The review is devoted to diagnosing bipolar affective disorder in adolescence. The article summarizes the domestic and foreign research findings concerning the early disease manifestations, the specific features of the disease course, and the relationship with mental and corporal comorbidity. Special attention is paid to the diagnosis of hypomania, based on the recommendations of modern international diagnostic systems: DSM-V (APA, 2013), and the draft International Classification of Diseases, ICD-11 2019. Early detection of affective disorder in adolescents using screening study methods is shown to be significant.

scholarly journals Childhood trauma and hallucinations in bipolar affective disorder: preliminary investigation

2003 ◽  
Vol 182 (6) ◽  
pp. 543-547 ◽  
Author(s):  
Paul Hammersley ◽  
Anton Dias ◽  
Gillian Todd ◽  
Kim Bowen-Jones ◽  
Bernadette Reilly ◽  
...  
Keyword(s):  
Sexual Abuse ◽  
Childhood Sexual Abuse ◽  
Affective Disorder ◽  
Childhood Trauma ◽  
Bipolar Affective Disorder ◽  
Preliminary Investigation ◽  
Behavioural Therapy ◽  
Auditory Hallucinations ◽  
Spontaneous Reports ◽  
The Relationship

BackgroundStrong evidence exists for an association between childhood trauma, particularly childhood sexual abuse, and hallucinations in schizophrenia. Hallucinations are also well-documented symptoms in people with bipolar affective disorder.AimsTo investigate the relationship between childhood sexual abuse and other childhood traumas and hallucinations in people with bipolar affective disorder.MethodA sample of 96 participants was drawn from the Medical Research Council multi-centre trial of cognitive–behavioural therapy for bipolar affective disorder. The trial therapists recorded spontaneous reports of childhood sexual abuse made during the course of therapy. Symptom data were collected by trained research assistants masked to the hypothesis.ResultsA significant association was found between those reporting general trauma (n=38) and auditory hallucinations. A highly significant association was found between those reporting childhood sexual abuse (n=15) and auditory hallucinations.ConclusionsThe relationship between childhood sexual abuse and hallucinations in bipolar disorder warrants further investigation.

scholarly journals Relationship between childhood adversity and bipolar affective disorder: systematic review and meta-analysis

2016 ◽  
Vol 209 (6) ◽  
pp. 454-459 ◽  
Author(s):  
J. E. Palmier-Claus ◽  
K. Berry ◽  
S. Bucci ◽  
W. Mansell ◽  
F. Varese
Keyword(s):  
Bipolar Disorder ◽  
Affective Disorder ◽  
Emotional Abuse ◽  
Meta Analysis ◽  
Bipolar Affective Disorder ◽  
Quantitative Measure ◽  
Childhood Adversity ◽  
Clinical Group ◽  
Search Terms ◽  
The Relationship

BackgroundThe relationship between childhood adversity and bipolar affective disorder remains unclear.AimsTo understand the size and significance of this effect through a statistical synthesis of reported research.MethodSearch terms relating to childhood adversity and bipolar disorder were entered into Medline, EMBASE, PsycINFO and Web of Science. Eligible studies included a sample diagnosed with bipolar disorder, a comparison sample and a quantitative measure of childhood adversity.ResultsIn 19 eligible studies childhood adversity was 2.63 times (95% CI 2.00–3.47) more likely to have occurred in bipolar disorder compared with non-clinical controls. The effect of emotional abuse was particularly robust (OR = 4.04, 95% CI 3.12–5.22), but rates of adversity were similar to those in psychiatric controls.ConclusionsChildhood adversity is associated with bipolar disorder, which has implications for the treatment of this clinical group. Further prospective research could clarify temporal causality and explanatory mechanisms.

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