Transcranial direct current stimulation (tDCS) for depression: Analysis of response using a three-factor structure of the Montgomery–Åsberg depression rating scale

2013 ◽  
Vol 150 (1) ◽  
pp. 91-95 ◽  
Author(s):  
Angelo Alonzo ◽  
Grace Chan ◽  
Donel Martin ◽  
Philip B. Mitchell ◽  
Colleen Loo
Keyword(s):  
Factor Structure ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Rating Scale ◽  
Direct Current Stimulation ◽  
Three Factor

scholarly journals Polarity Specific Suppression Effects of Transcranial Direct Current Stimulation for Tinnitus

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Kathleen Joos ◽  
Dirk De Ridder ◽  
Paul Van de Heyning ◽  
Sven Vanneste
Keyword(s):  
Auditory Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Rating Scale ◽  
Suppressive Effect ◽  
Numeric Rating Scale ◽  
Direct Current Stimulation ◽  
Specific Effects ◽  
Anodal Stimulation ◽  
Effect Of Treatment

Tinnitus is the perception of a sound in the absence of an external auditory stimulus and affects 10–15% of the Western population. Previous studies have demonstrated the therapeutic effect of anodal transcranial direct current stimulation (tDCS) over the left auditory cortex on tinnitus loudness, but the effect of this presumed excitatory stimulation contradicts with the underlying pathophysiological model of tinnitus. Therefore, we included 175 patients with chronic tinnitus to study polarity specific effects of a single tDCS session over the auditory cortex (39 anodal, 136 cathodal). To assess the effect of treatment, we used the numeric rating scale for tinnitus loudness and annoyance. Statistical analysis demonstrated a significant main effect for tinnitus loudness and annoyance, but for tinnitus annoyance anodal stimulation has a significantly more pronounced effect than cathodal stimulation. We hypothesize that the suppressive effect of tDCS on tinnitus loudness may be attributed to a disrupting effect of ongoing neural hyperactivity, independent of the inhibitory or excitatory effects and that the reduction of annoyance may be induced by influencing adjacent or functionally connected brain areas involved in the tinnitus related distress network. Further research is required to explain why only anodal stimulation has a suppressive effect on tinnitus annoyance.

scholarly journals Influence of Transcranial Direct Current Stimulation on Psychomotor Symptoms in Major Depression

2020 ◽  
Vol 10 (11) ◽  
pp. 792
Author(s):  
Djamila Bennabi ◽  
Nicolas Carvalho ◽  
Ambra Bisio ◽  
Juliana Teti Mayer ◽  
Thierry Pozzo ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Rating Scale ◽  
Small Sample ◽  
Psychomotor Activity ◽  
Direct Current Stimulation ◽  
Depressed Patients ◽  
Dorsolateral Prefrontal

Background: Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (dlPFC) might be a promising treatment strategy for depression. As disturbances in psychomotor activity are one of the key features of unipolar depression are, we aimed to evaluate the behavioral effects of ten tDCS sessions over a 5-day period on psychomotor retardation in depressed patients. Methods: Twenty-three treatment-resistant depressed patients received either active or sham anodal tDCS to the left dorsolateral prefrontal cortex (2 mA, 10 sessions over 1 week). Psychomotor functioning was registered by means of observer ratings (Salpêtrière Retardation Rating Scale—SRRS) and objective measures (kinematical analysis of movements, automatic imitation). Results: tDCS sessions resulted in improvements on SRRS scores, although active tDCS was not significantly superior to sham tDCS on the kinematical parameters. Furthermore, no general additional antidepressant effect of tDCS was observed. The relatively small sample size and the short periods of observation should be considered when interpreting these results. Conclusion: tDCS did not induce a clinically relevant effect on psychomotor function in active and sham stimulation groups.

Effects of Transcranial Direct Current Stimulation for Treatment of Primary Dysmenorrhea: Preliminary Results of a Randomized Sham-Controlled Trial

Pain Medicine ◽  
2019 ◽  
Vol 21 (12) ◽  
pp. 3615-3623 ◽  
Author(s):  
Rodrigo Pegado ◽  
Luana Karyne Silva ◽  
Hégila da Silva Dantas ◽  
Hialison Andrade Câmara ◽  
Karime Andrade Mescouto ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Group Intervention ◽  
Rating Scale ◽  
Controlled Trial ◽  
Preliminary Evidence ◽  
Primary Dysmenorrhea ◽  
Double Blind ◽  
Direct Current Stimulation

Abstract Objective The aim of this trial was to investigate the effects of five consecutive sessions of anodal transcranial direct current stimulation (tDCS) over the motor cortex (M1) on pain, mood, and physical performance in patients with primary dysmenorrhea (PDM). Design This is a double-blind randomized controlled trial. Subjects Twenty-two participants with PDM according to the No. 345-PDM Consensus Guideline were included. Methods Eleven active treatment and 11 sham stimulation patients received five applications over a one-week period. The primary outcome measures were pain evaluated by numeric rating scale (NRS) and McGill Questionnaire score. Secondary outcomes measures were responses to the Positive and Negative Affect Schedule (PANAS), Hamilton Anxiety Scale (HAM-A), grip strength, and six-minute walk test (6MWT). Baseline data were performed during the first menstrual cycle, and during the second menstrual cycle, participants were conducted to tDCS treatment, and postintervention data were collected. Results The intervention provided significant improvements on NRS in active tDCS, shown as an interaction between group intervention vs pre/postintervention vs days of menstrual cycle (Wald x2 = 10.54, P = 0.005), main effect of days of menstrual cycle (Wald x2 = 25.42, P < 0.001), and pre/postintervention (Wald x2 = 6.97, P = 0.008). McGill showed an interaction effect between pre/postintervention and group of stimulation (Wald x2 = 18.45, P = 0.001), with a large reduction in active tDCS (P < 0.001, d = 0.75). Psychological and functional outcomes did not differ between groups or pre/postintervention. Conclusions tDCS could provide pain relief in subjects with PDM. These results provide some preliminary evidence for the potential role of tDCS as a contributor to the management of symptoms of PDM.

Augmentative transcranial direct current stimulation (tDCS) in poor responder depressed patients: a follow-up study

CNS Spectrums ◽  
2013 ◽  
Vol 19 (4) ◽  
pp. 347-354 ◽  
Author(s):  
Bernardo Dell'Osso ◽  
Cristina Dobrea ◽  
Chiara Arici ◽  
Beatrice Benatti ◽  
Roberta Ferrucci ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Repeated Measures ◽  
Rating Scale ◽  
Drop Out ◽  
Young Mania ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Follow Up Study

ObjectivesTranscranial direct current stimulation (tDCS) is a non-invasive neurostimulation technique that has received increasing interest in the area of mood disorders over the last several years. While acute, double-blind, sham-controlled studies have already reported positive findings in terms of efficacy and safety for tDCS, follow-up data are lacking. This need prompted the present follow-up study, which assesses post-acute effects of tDCS (no maintenance stimulation was performed), in the mid-term, in a sample of major depressives.MethodsAfter completing an acute, open trial of tDCS, 23 outpatients with either major depressive disorder or bipolar disorder entered a naturalistic follow-up (T1) with clinical evaluations at one week (T2), 1 month (T3), and 3 months (T4). A quantitative analysis of Hamilton Depression Rating Scale (HAM-D), Montgomery–Asberg Depression Rating Scale (MADRS), and Young Mania Rating Scale (YMRS) total scores, through repeated measures analysis of variance (ANOVA) (T1–T4) and paired t-test for comparing specific time points (T1–T2, T2–T3, and T3–T4), was performed. In addition, a qualitative analysis on the basis of treatment response and remission (HAM-D) was performed.ResultsEven though a progressive reduction of follow-up completers was observed from T2 to T4 (95.6% at T2, 65.2% at T3, and 47.8% at T4), the antidepressant effects of acute tDCS persisted over 3 months in almost half of the sample. Of note, no post-acute side effects emerged during the follow-up observation. The most frequent causes of drop-out from this study included major modifications in therapeutic regimen (30%) and poor adherence to follow-up visits (17%).ConclusionsIn this mid-term, open, follow-up study, tDCS showed mixed results. Further controlled studies are urgently needed to assess its effects beyond the acute phase.

scholarly journals Scaffolding the Attention-Deficit/Hyperactivity Disorder Brain Using Random Noise Stimulation

2019 ◽  
Author(s):  
Itai Berger ◽  
Ornella Dakwar-Kawar ◽  
Ephraim S. Grossman ◽  
Mor Nahum ◽  
Roi Cohen Kadosh
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Working Memory ◽  
Direct Current ◽  
Attention Deficit ◽  
Transcranial Direct Current Stimulation ◽  
Rating Scale ◽  
Random Noise ◽  
Direct Current Stimulation ◽  
Hyperactivity Disorder ◽  
Transcranial Random Noise Stimulation

AbstractVarious methods have been attempted to effectively ameliorate psychiatric and neurological conditions in children and adults. One of the attractive ideas is to develop interventions to create a lasting, rather than only an immediate, effect. Neurostimulation has been shown to yield long-term effect when combined with cognitive training in healthy young adults. We examined whether such approach could benefit children with attention deficit hyperactivity disorder (ADHD), the most common neurodevelopmental disorder in childhood. We used a randomized double-blind active-controlled crossover study of 19 unmedicated children (aged 7–12 years old) with attention deficit hyperactivity disorder, who received either transcranial direct current stimulation or random noise stimulation while completing five-day executive functions training, which includes working memory, cognitive flexibility, and inhibition tasks. Both stimulation protocols have previously shown potential for inducing lasting benefits in adults, while transcranial direct current stimulation was examined in multiple attention deficit hyperactivity disorder studies and has been highlighted as a promising method for treating neuropsychological deficits. For our primary outcome, transcranial random noise stimulation yielded a clinical improvement as indicated by the reduced attention deficit hyperactivity disorder rating scale score from baseline, and in comparison to the changes observed in transcranial direct current stimulation. Moreover, the effect of brain stimulation one week after completion of treatment yielded further improvement, suggesting a neuroplasticity-related effect. Finally, transcranial random noise stimulation improved working memory compared to transcranial direct current stimulation, and a larger transcranial random noise stimulation effect on attention deficit hyperactivity disorder rating scale was predicted for those patients who showed the greatest improvement in working memory. Our results provide a promising direction toward a novel intervention in attention deficit hyperactivity disorder, which is shown to have a lasting effect via the modulating of neuroplasticity, rather than a merely immediate effect as was shown for in previous medical interventions.

Interactions between transcranial direct current stimulation (tDCS) and pharmacological interventions in the Major Depressive Episode: Findings from a naturalistic study

2013 ◽  
Vol 28 (6) ◽  
pp. 356-361 ◽  
Author(s):  
A.R. Brunoni ◽  
R. Ferrucci ◽  
M. Bortolomasi ◽  
E. Scelzo ◽  
P.S. Boggio ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Pharmacological Treatment ◽  
Rating Scale ◽  
Outcome Variable ◽  
Naturalistic Study ◽  
Direct Current Stimulation ◽  
Dorsolateral Prefrontal ◽  
Benzodiazepine Use ◽  
The Right

AbstractBackground:Transcranial direct current stimulation (tDCS) is a non-invasive, neuromodulatory technique with an emerging role for treating major depression.Objective:To investigate the interactions between tDCS and drug therapy in unipolar and bipolar depressed patients who were refractory for at least one pharmacological treatment.Methods:This was a naturalistic study using data from 54 female and 28 male patients (mean age of 54 years) that consecutively visited our psychiatric unit. They received active tDCS (five consecutive days, 2 mA, anodal stimulation over the left and cathodal over the right dorsolateral prefrontal cortex, twice a day, 20 minutes). The outcome variable (mood) was evaluated using the Beck Depression Inventory (BDI) and the Hamilton Depression Rating Scale (HDRS). Predictor variables were age, gender, disorder and pharmacological treatment (seven dummy variables). We performed univariate and multivariate analyses as to identify predictors associated to the outcome.Results:After 5 days of treatment, BDI and HDRS scores decreased significantly (29% ± 36%, 18% ± 9%, respectively, P < 0.01 for both). Benzodiazepine use was independently associated with a worse outcome in both univariate (β = 4.92, P < 0.01) and multivariate (β = 5.8, P < 0.01) analyses; whereas use of dual-reuptake inhibitors positively changed tDCS effects in the multivariate model (β = –4.7, P = 0.02). A similar trend was observed for tricyclics (β = –4, P = 0.06) but not for antipsychotics, non-benzodiazepine anticonvulsants and other drugs.Conclusion:tDCS over the DLPFC acutely improved depressive symptoms. Besides the inherent limitations of our naturalistic design, our results suggest that tDCS effects might vary according to prior pharmacological treatment, notably benzodiazepines and some antidepressant classes. This issue should be further explored in controlled studies.

scholarly journals In-vivo imaging of targeting and modulation of depression-relevant circuitry by transcranial direct current stimulation: a randomized clinical trial

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mayank. S. Jog ◽  
Elizabeth Kim ◽  
Cole Anderson ◽  
Antoni Kubicki ◽  
Rishikesh Kayathi ◽  
...  
Keyword(s):  
Magnetic Fields ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Rating Scale ◽  
Neural Circuitry ◽  
Post Treatment ◽  
Anterior Cingulate ◽  
Direct Current Stimulation ◽  
Left Dlpfc

AbstractRecent clinical trials of transcranial direct current stimulation (tDCS) in depression have shown contrasting results. Consequently, we used in-vivo neuroimaging to confirm targeting and modulation of depression-relevant neural circuitry by tDCS. Depressed participants (N = 66, Baseline Hamilton Depression Rating Scale (HDRS) 17-item scores ≥14 and <24) were randomized into Active/Sham and High-definition (HD)/Conventional (Conv) tDCS groups using a double-blind, parallel design, and received tDCS individually targeted at the left dorsolateral prefrontal cortex (DLPFC). In accordance with Ampere’s Law, tDCS currents were hypothesized to induce magnetic fields at the stimulation-target, measured in real-time using dual-echo echo-planar-imaging (DE-EPI) MRI. Additionally, the tDCS treatment trial (consisting of 12 daily 20-min sessions) was hypothesized to induce cerebral blood flow (CBF) changes post-treatment at the DLPFC target and in the reciprocally connected anterior cingulate cortex (ACC), measured using pseudo-continuous arterial spin labeling (pCASL) MRI. Significant tDCS current-induced magnetic fields were observed at the left DLPFC target for both active stimulation montages (Brodmann’s area (BA) 46: pHD = 0.048, Cohen’s dHD = 0.73; pConv = 0.018, dConv = 0.86; BA 9: pHD = 0.011, dHD = 0.92; pConv = 0.022, dConv = 0.83). Significant longitudinal CBF increases were observed (a) at the left DLPFC stimulation-target for both active montages (pHD = 3.5E−3, dHD = 0.98; pConv = 2.8E−3, dConv = 1.08), and (b) at ACC for the HD-montage only (pHD = 2.4E−3, dHD = 1.06; pConv = 0.075, dConv = 0.64). These results confirm that tDCS-treatment (a) engages the stimulation-target, and (b) modulates depression-relevant neural circuitry in depressed participants, with stronger network-modulations induced by the HD-montage. Although not primary outcomes, active HD-tDCS showed significant improvements of anhedonia relative to sham, though HDRS scores did not differ significantly between montages post-treatment.

scholarly journals Effect of Anodal Transcranial Direct Current Stimulation on Autism: A Randomized Double-Blind Crossover Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Anuwat Amatachaya ◽  
Narong Auvichayapat ◽  
Niramol Patjanasoontorn ◽  
Chanyut Suphakunpinyo ◽  
Niran Ngernyam ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Crossover Trial ◽  
Rating Scale ◽  
Clinical Tool ◽  
Global Assessment Scale ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Autism Treatment ◽  
Dorsolateral Prefrontal

The aim of this study was to evaluate the Childhood Autism Rating Scale (CARS), Autism Treatment Evaluation Checklist (ATEC), and Children’s Global Assessment Scale (CGAS) after anodal transcranial direct current stimulation (tDCS) in individuals with autism. Twenty patients with autism received 5 consecutive days of both sham and active tDCS stimulation (1 mA) in a randomized double-blind crossover trial over the left dorsolateral prefrontal cortex (F3) for 20 minutes in different orders. Measures of CARS, ATEC, and CGAS were administered before treatment and at 7 days posttreatment. The result showed statistical decrease in CARS score (P<0.001). ATEC total was decreased from 67.25 to 58 (P<0.001). CGAS was increased at 7 days posttreatment (P=0.042). Our study suggests that anodal tDCS over the F3 may be a useful clinical tool in autism.

Transcranial direct current stimulation and retraining in musician's hand dystonia

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
F Buttkus ◽  
V Baur ◽  
HC Jabusch ◽  
M Weidenmüller ◽  
S Schneider ◽  
...  
Keyword(s):  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation ◽  
Hand Dystonia
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