scholarly journals The bidirectional relationships between alcohol, cannabis, co-occurring alcohol and cannabis use disorders with major depressive disorder: Results from a national sample

2013 ◽  
Vol 148 (2-3) ◽  
pp. 188-195 ◽  
Author(s):  
Lauren R. Pacek ◽  
Silvia S. Martins ◽  
Rosa M. Crum
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
National Sample ◽  
Cannabis Use ◽  
Major Depressive ◽  
Cannabis Use Disorders

scholarly journals Major Depressive Disorder in Long-Term Cancer Survivors: Analysis of the National Comorbidity Survey Replication

2009 ◽  
Vol 27 (25) ◽  
pp. 4130-4134 ◽  
Author(s):  
William F. Pirl ◽  
Joseph Greer ◽  
Jennifer S. Temel ◽  
Beow Y. Yeap ◽  
Stephen E. Gilman
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cancer Survivors ◽  
National Sample ◽  
Major Depressive ◽  
Cross Sectional ◽  
Cancer History ◽  
National Comorbidity Survey Replication ◽  
National Comorbidity Survey

Purpose Prior research is mixed as to whether long-term cancer survivors (LCSs) have higher rates of depression than the general population. This is the first study to compare the rates of major depressive disorder (MDD) between LCSs and people without cancer histories in a nationally representative cross-sectional multistage cluster survey sample, the National Comorbidity Survey-Replication (NCS-R). Methods Between 2001 and 2003, face-to-face interviews were conducted for the NCS-R in a national sample of 9,282 people, of whom 5,692 were assessed for a history of cancer. Participants with cancer diagnoses at least 5 years before the interview were considered LCSs. Survivors of childhood cancers were excluded. Comparing LCSs to those without a cancer history, odds ratios for having a MDD episode in the last 12 months before interview were obtained using multiple logistic regression controlling for demographic and medical variables. Differences in characteristics of those MDD episodes were also compared between groups. Results Of participants age 23 years or older, 243 LCSs and 4,890 adults without a cancer history were identified in the sample. Adjusting for demographic variables and medical comorbidities, LCSs did not have increased odds of MDD in the last 12 months, with an odds ratio of (OR) 0.99 (95% CI, 0.55 to 1.79). LCSs reported higher mean levels of impairment from MDD in their home, social, and work life, but these differences were not significant. Conclusion LCSs do not appear to have elevated rates of MDD. However, they may experience greater impairment from MDD compared to those without cancer. Longitudinal studies are needed to confirm these findings.

scholarly journals Major Depressive Disorder, Suicidal Ideation, and Suicide Attempt inTwins Discordant for Cannabis Dependence and Early-Onset Cannabis Use

2004 ◽  
Vol 61 (10) ◽  
pp. 1026 ◽  
Author(s):  
Michael T. Lynskey ◽  
Anne L. Glowinski ◽  
Alexandre A. Todorov ◽  
Kathleen K. Bucholz ◽  
Pamela A. F. Madden ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Suicidal Ideation ◽  
Suicide Attempt ◽  
Depressive Disorder ◽  
Early Onset ◽  
Cannabis Use ◽  
Major Depressive ◽  
Cannabis Dependence

scholarly journals Emotion regulation in emerging adults with major depressive disorder and frequent cannabis use

2020 ◽  
Author(s):  
Emily S. Nichols ◽  
Jacob Penner ◽  
Kristen A. Ford ◽  
Michael Wammes ◽  
Richard W.J. Neufeld ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Emotion Regulation ◽  
Depressive Symptoms ◽  
Depressive Disorder ◽  
Emerging Adults ◽  
Superior Temporal Gyrus ◽  
Cannabis Use ◽  
Middle Temporal Gyrus ◽  
Major Depressive ◽  
Middle Temporal

AbstractIn people with mental health issues, approximately 20% have co-occurring substance use, often involving cannabis. Although emotion regulation can be affected both by major depressive disorder (MDD) and by cannabis use, the relationship among all three factors is unknown. In this study, we used fMRI to evaluate the effect that cannabis use and MDD have on brain activation during an emotion regulation task. Differences were assessed in 74 emerging adults aged 16-23 with and without MDD who either used or did not use cannabis. Severity of depressive symptoms, emotion regulation style, and age of cannabis use onset were also measured. Both MDD and cannabis use interacted with the emotion regulation task in the left temporal lobe, however the location of the interaction differed for each factor. Specifically, MDD showed an interaction with emotion regulation in the middle temporal gyrus, whereas cannabis use showed an interaction in the superior temporal gyrus. Emotion regulation style predicted activity in the right superior frontal gyrus, however, this did not interact with MDD or cannabis use. Severity of depressive symptoms interacted with the emotion regulation task in the left middle temporal gyrus. The results highlight the influence of cannabis use and MDD on emotion regulation processing, suggesting that both may have a broader impact on the brain than previously thought.

scholarly journals Emotion regulation in emerging adults with major depressive disorder and frequent cannabis use

2021 ◽  
Vol 30 ◽  
pp. 102575
Author(s):  
Emily S. Nichols ◽  
Jacob Penner ◽  
Kristen A. Ford ◽  
Michael Wammes ◽  
Richard W.J. Neufeld ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Emotion Regulation ◽  
Depressive Disorder ◽  
Emerging Adults ◽  
Cannabis Use ◽  
Major Depressive

scholarly journals Developmental sensitivity to cannabis use patterns and risk for major depressive disorder in mid-life: findings from 40 years of follow-up

2018 ◽  
Vol 48 (13) ◽  
pp. 2169-2176 ◽  
Author(s):  
Tabea Schoeler ◽  
Delphine Theobald ◽  
Jean-Baptiste Pingault ◽  
David P. Farrington ◽  
Jeremy W. Coid ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Early Onset ◽  
Fixed Effects ◽  
Longitudinal Design ◽  
Later Life ◽  
Cannabis Use ◽  
Major Depressive ◽  
Increased Risk

AbstractBackgroundEvidence regarding the association between cannabis use and depression remain conflicting, especially as studies have not typically adopted a longitudinal design with a follow-up period that was long enough to adequately cover the risk period for onset of depression.MethodMales from the Cambridge Study in Delinquent Development (CSDD) (N = 285) were assessed seven times from age 8 to 48 years to prospectively investigate the association between cannabis use and risk of major depressive disorder (MDD). A combination of multiple analyses (logistic regression, Cox regression, fixed-effects analysis) was employed to explore the strength and direction of effect within different developmental stages.ResultsMultiple regression analyses revealed that early-onset cannabis use (before age 18) but not late-onset cannabis use (after age 27) was associated with a higher risk and shorter time until a subsequent MDD diagnosis. This effect was present in high-frequency [(odds ratio (OR) 8.83, 95% confidence interval (CI) 1.29–70.79]; [hazard ratio (HR) 8.69, 95% CI 2.07–36.52)] and low-frequency early-onset users (OR 2.41, 95% CI 1.22–4.76; HR 2.09, 95% CI 1.16–3.74). Effect of increased frequency of cannabis use on increased risk of subsequent MDD was observed only for use during adolescence (age 14–18) but not at later life stages, while controlling for observed and non-unobserved time-invariant factors. Conversely, MDD in adulthood (age 18–32) was linked to a reduction in subsequent cannabis use (age 32–48).ConclusionsThe present findings provide evidence implicating frequent cannabis use during adolescence as a risk factor for later life depression. Future studies should further examine causality of effects in larger samples.

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