Symptom specificity in the acute treatment of Major Depressive Disorder: A re-analysis of the treatment of depression collaborative research program

2012 ◽  
Vol 137 (1-3) ◽  
pp. 87-97 ◽  
Author(s):  
Jeremy G. Stewart ◽  
Kate L. Harkness
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Research Program ◽  
Collaborative Research ◽  
Acute Treatment ◽  
Major Depressive ◽  
Treatment Of Depression

Evaluation of psychosocial functioning in the acute treatment term of major depressive disorder: a 16-week multi-centered follow-up study

2021 ◽  
pp. 102883
Author(s):  
Neslihan ALTUNSOY ◽  
Didem SÜCÜLLÜOĞLU DİKİCİ ◽  
Fikret Poyraz ÇÖKMÜŞ ◽  
Hüseyin Murat ÖZKAN ◽  
Kadir AŞÇIBAŞI ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Psychosocial Functioning ◽  
Acute Treatment ◽  
Major Depressive ◽  
Follow Up Study

Uncomplicated Depression as Normal Sadness

2016 ◽  
pp. 82-94
Author(s):  
Jerome C. Wakefield ◽  
Allan V. Horwitz ◽  
Lorenzo Lorenzo-Luaces
Keyword(s):  
Major Depressive Disorder ◽  
Anxiety Disorder ◽  
Major Depression ◽  
General Population ◽  
Depressive Disorder ◽  
Generalized Anxiety Disorder ◽  
Research Program ◽  
Generalized Anxiety ◽  
Major Depressive ◽  
Depressive Episodes

About half of all individuals meet the criteria for DSM-defined major depressive disorder (MDD) by the age of 30. These and other considerations suggest that MDD criteria are too inclusive and apply to individuals who are not ill but are experiencing normal sadness. This chapter reviews a research program that attempts to address this issue by examining “uncomplicated depression,” a subcategory of MDD that is hypothesized to consist of false positive diagnoses in which normal sadness is misdiagnosed as MDD. Data on uncomplicated depression suggest that many individuals who currently meet the DSM criteria for MDD are at no greater risk for subsequent depressive episodes, attempting suicide, or development of generalized anxiety disorder than members of the general population. These data suggest that uncomplicated depression is normal sadness, not major depression, and should not be diagnosed as disordered. They thus indicate that current DSM criteria for MDD are overly inclusive.

Outcomes of Recognizing Depressed Chinese American Patients in Primary Care

2005 ◽  
Vol 35 (3) ◽  
pp. 213-224 ◽  
Author(s):  
Albert Yeung ◽  
Winnie W. Kung ◽  
Jessica L. Murakami ◽  
David Mischoulon ◽  
Jonathan E. Alpert ◽  
...  
Keyword(s):  
Primary Care ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Primary Care Physicians ◽  
Primary Care Clinic ◽  
Chinese American ◽  
Chinese Americans ◽  
Major Depressive ◽  
Care Clinic ◽  
Treatment Of Depression

Purpose: This study aims to examine the effect of identifying Chinese American patients as having major depressive disorder (MDD) to their primary care physicians (PCPs) on the latter's attention given to the treatment of depression. Methodology: Forty Chinese American patients from a primary care clinic were identified as having major depressive disorder (MDD), and their primary care physicians (PCPs) were notified of the diagnosis by letter. Three months later, medical records of subjects in the study were reviewed to see if their PCPs had intervened through referral and/or initiated treatment of depression. Results: PCPs documented intervention in 19 patients (47%) regarding their depression. Two of these patients (11%) were started on an antidepressant. Four (21%) accepted and 13 (68%) declined referral to mental health services. No intervention was recorded for 21 (53%) patients. Conclusion: We conclude that recognition alone of MDD among Chinese Americans in the community primary care setting does not lead to adequate initiation of treatment for depression by PCPs.

Precision Medicine for the Treatment of Depression

Depression ◽  
2019 ◽  
pp. 475-486
Author(s):  
Madhukar H. Trivedi ◽  
Farra Kahalnik ◽  
Tracy L. Greer
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Precision Medicine ◽  
Treatment Outcomes ◽  
Treatment Response ◽  
Successful Treatment ◽  
Biological Markers ◽  
Major Depressive ◽  
Ongoing Research ◽  
Treatment Of Depression

Although in recent years we have gained a deeper understanding of the pathophysiology of major depressive disorder, this improved understanding has not translated into improved treatment outcomes. Therefore, the screening of putative biological markers may be crucial to facilitate more rapid, successful treatment. Ongoing research has explored the importance of studying physiological biomarkers, including neuroimaging, neurophysiology, genomics, proteomics, and metabolomics, as well as cognition, to gain a better understanding of subtypes of depression and treatment response. However, only through an integrated, multimodal biomarker approach can we truly achieve better outcomes.

The Impact of Medical Comorbidity on Acute Treatment in Major Depressive Disorder

2003 ◽  
Vol 160 (12) ◽  
pp. 2122-2127 ◽  
Author(s):  
Dan V. Iosifescu ◽  
Andrew A. Nierenberg ◽  
Jonathan E. Alpert ◽  
Megan Smith ◽  
Stella Bitran ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Acute Treatment ◽  
Medical Comorbidity ◽  
Major Depressive ◽  
The Impact

Clinical and Functional Characteristics of Cognitive Dysfunction in Major Depressive Disorder

2019 ◽  
pp. 45-58 ◽  
Author(s):  
Maria Serra-Blasco ◽  
Raymond W. Lam
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Cognitive Dysfunction ◽  
Functional Recovery ◽  
Clinical Characteristics ◽  
First Episode ◽  
Functional Impairments ◽  
Major Depressive ◽  
Treatment Of Depression ◽  
Cardinal Symptom

Cognitive dysfunction is a cardinal symptom of depression that significantly contributes to the psychosocial and occupational impairment experienced by patients with major depressive disorder (MDD). This chapter examines the important clinical characteristics and functional impairments associated with cognitive dysfunction in patients with MDD. Although cognitive dysfunction can also be identified in first-episode MDD, depressed patients with greater illness burden (severity, recurrence) and specific subtypes (melancholic, psychotic) have more severe cognitive deficits and poorer functioning. Cognitive dysfunction can also persist during treatment of depression, even when other depressive symptoms are in remission, and can be a barrier to functional recovery. Clinicians should therefore assess, monitor, and target cognitive dysfunction in the treatment of patients with MDD to optimize their potential for full functional recovery.

scholarly journals The interface between neurology and psychiatry: the case of multiple sclerosis

2013 ◽  
Vol 19 (5) ◽  
pp. 370-377
Author(s):  
Eugene K. O. Wong ◽  
Rajeev Krishnadas ◽  
Jonathan Cavanagh
Keyword(s):  
Multiple Sclerosis ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Psychiatric Practice ◽  
Major Depressive ◽  
Treatment Of Depression ◽  
Recent Developments ◽  
Anti Inflammatory

SummaryThere has been a surge in interest in the boundaries of psychiatry, both as a specialty in its own right and as a branch of medicine separate from neurology. Our article expands on this, giving examples of how recent developments in neuroimmunology can be beneficial for psychiatry, using multiple sclerosis (MS) as an example. We also provide a summary of literature on novel research in the treatment of depression using anti-inflammatory agents. Finally, we suggest approaches to the identification and management of major depressive disorder in patients with MS or other physical illnesses, and how this translates to general psychiatric practice.

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