The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive–compulsive disorder

2010 ◽  
Vol 124 (3) ◽  
pp. 309-313 ◽  
Author(s):  
Murad Atmaca ◽  
Ebru Onalan ◽  
Hanefi Yildirim ◽  
Huseyin Yuce ◽  
Mustafa Koc ◽  
...  
Keyword(s):  
White Matter ◽  
Obsessive Compulsive Disorder ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
White Matter Volume ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Glycoprotein Gene ◽  
Matter Volume

Changes in Gray Matter Volume and White Matter Microstructure in Adolescents with Obsessive-Compulsive Disorder

2011 ◽  
Vol 70 (11) ◽  
pp. 1083-1090 ◽  
Author(s):  
Mojtaba Zarei ◽  
David Mataix-Cols ◽  
Isobel Heyman ◽  
Morgan Hough ◽  
Joanne Doherty ◽  
...  
Keyword(s):  
White Matter ◽  
Obsessive Compulsive Disorder ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Matter Volume ◽  
White Matter Microstructure

Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder

2004 ◽  
Vol 129B (1) ◽  
pp. 64-68 ◽  
Author(s):  
Gwyneth Zai ◽  
Yarema B. Bezchlibnyk ◽  
Margaret A. Richter ◽  
Paul Arnold ◽  
Eliza Burroughs ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Myelin Oligodendrocyte Glycoprotein ◽  
Obsessive Compulsive ◽  
Compulsive Disorder

scholarly journals Neurocircuitry of Deep Brain Stimulation for Obsessive-Compulsive Disorder as Revealed by Tractography: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Eduardo Varjão Vieira ◽  
Paula Ricci Arantes ◽  
Clement Hamani ◽  
Ricardo Iglesio ◽  
Kleber Paiva Duarte ◽  
...  
Keyword(s):  
Systematic Review ◽  
Deep Brain Stimulation ◽  
White Matter ◽  
Data Processing ◽  
Obsessive Compulsive Disorder ◽  
Brain Stimulation ◽  
Diffusion Tensor ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Deep Brain

Objective: Deep brain stimulation (DBS) was proposed in 1999 to treat refractory obsessive-compulsive disorder (OCD). Despite the accumulated experience over more than two decades, 30–40% of patients fail to respond to this procedure. One potential reason to explain why some patients do not improve in the postoperative period is that DBS might not have engaged structural therapeutic networks that are crucial to a favorable outcome in non-responders. This article reviews magnetic resonance imaging diffusion studies (DTI-MRI), analyzing neural networks likely modulated by DBS in OCD patients and their corresponding clinical outcome.Methods: We used a systematic review process to search for studies published from 2005 to 2020 in six electronic databases. Search terms included obsessive-compulsive disorder, deep brain stimulation, diffusion-weighted imaging, diffusion tensor imaging, diffusion tractography, tractography, connectome, diffusion analyses, and white matter. No restriction was made concerning the surgical target, DTI-MRI technique and the method of data processing.Results: Eight studies published in the last 15 years were fully assessed. Most of them used 3 Tesla DTI-MRI, and different methods of data acquisition and processing. There was no consensus on potential structures and networks underlying DBS effects. Most studies stimulated the ventral anterior limb of the internal capsule (ALIC)/nucleus accumbens. However, the contribution of different white matter pathways that run through the ALIC for the effects of DBS remains elusive. Moreover, the improvement of cognitive and affective symptoms in OCD patients probably relies on electric modulation of distinct networks.Conclusion: Though, tractography is a valuable tool to understand neural circuits, the effects of modulating different fiber tracts in OCD are still unclear. Future advances on image acquisition and data processing and a larger number of studies are still required for the understanding of the role of tractography-based targeting and to clarify the importance of different tracts for the mechanisms of DBS.

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