Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments

2008 ◽  
Vol 105 (1-3) ◽  
pp. 279-283 ◽  
Author(s):  
Armando Piccinni ◽  
Donatella Marazziti ◽  
Mario Catena ◽  
Luciano Domenici ◽  
Alessandro Del Debbio ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Antidepressant Treatments ◽  
Depressed Patients

scholarly journals Association between plasma levels of BDNF and the antisuicidal effects of repeated ketamine infusions in depression with suicidal ideation

2020 ◽  
Vol 10 ◽  
pp. 204512532097379
Author(s):  
Wei Zheng ◽  
Yan-Ling Zhou ◽  
Cheng-Yu Wang ◽  
Xiao-Feng Lan ◽  
Bin Zhang ◽  
...  
Keyword(s):  
Suicidal Ideation ◽  
Correlation Analysis ◽  
Immunosorbent Assay ◽  
Neurotrophic Factor ◽  
Plasma Levels ◽  
Rating Scale ◽  
Brain Derived Neurotrophic Factor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Depressed Patients ◽  
Over Time

Background: This study is the first to examine the association between plasma levels of brain-derived neurotrophic factor (BDNF) and the antisuicidal effects of repeated ketamine infusions in depressed patients with suicidal ideation. Methods: Fifty-seven depressed patients with suicidal ideation received six ketamine infusions (0.5 mg/kg) during a 12 days period. Suicidality was measured with the Scale for Suicidal Ideations (SSI-part 1), item 10 of the Montgomery–Åsberg Depression Rating Scale (MADRS), and item 3 of the Hamilton Depression Rating Scale (HAMD) at baseline, 1 day after the first infusion (1 day), 1 day after the sixth infusion (13 days), and at 2 weeks after the last infusion (26 days). Plasma levels of BDNF were measured by enzyme-linked immunosorbent assay at baseline, 13 days, and 26 days. Results: Overall, 46 (80.7%) depressed patients with suicidal ideation had an antisuicidal response at 13 days. Despite a significant reduction in suicidal symptoms over time, no changes in plasma levels of BDNF were found after ketamine treatment when compared with baseline. Correlation analysis showed that no significant association was observed between the plasma levels of BDNF and the changes in the severity of suicidal symptoms as measured by SSI-part 1, item 10 of the MADRS, or item 3 of the HAMD at 1 day, 13 days, and 26 days (all p < 0.05). Conclusion: Our results indicated that plasma levels of BDNF may not serve as a biomarker for determining the antisuicidal effects of six ketamine infusions in depressed patients with suicidal ideation.

Effects of fluoxetine and venlafaxine on serum brain derived neurotrophic factor levels in depressed patients

2009 ◽  
Vol 33 (2) ◽  
pp. 281-285 ◽  
Author(s):  
Ayse Devrim Başterzi ◽  
Kemal Yazici ◽  
Eda Aslan ◽  
Nuran Delialioğlu ◽  
Bahar Taşdelen ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Depressed Patients

Effect of treatment on serum brain–derived neurotrophic factor levels in depressed patients

2005 ◽  
Vol 255 (6) ◽  
pp. 381-386 ◽  
Author(s):  
A. Saffet Gonul ◽  
F. Akdeniz ◽  
F. Taneli ◽  
O. Donat ◽  
Ç. Eker ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Depressed Patients ◽  
Effect Of Treatment

scholarly journals Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Antidepressant Efficacy of Ketamine in Depressed Patients

2012 ◽  
Vol 72 (11) ◽  
pp. e27-e28 ◽  
Author(s):  
Gonzalo Laje ◽  
Níall Lally ◽  
Daniel Mathews ◽  
Nancy Brutsche ◽  
Anat Chemerinski ◽  
...  
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
Depressed Patients ◽  
Antidepressant Efficacy

scholarly journals Aerobic Exercise Does Not Predict Brain Derived Neurotrophic Factor And Cortisol Alterations in Depressed Patients

2015 ◽  
Vol 14 (9) ◽  
pp. 1116-1128 ◽  
Author(s):  
Murilo Lamego ◽  
Antonio de Souza Moura ◽  
Flávia Paes ◽  
Nuno Ferreira Rocha ◽  
Alberto de Sá Filho ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Depressed Patients

Analysis of human platelets brain-derived neurotrophic factor as a predictor of response in depressed patients

2014 ◽  
Vol 39 (3) ◽  
pp. 149
Author(s):  
AbdulrahmanFahmi Alshaik ◽  
RokiaSaad Ayyad ◽  
MaiA Eissa ◽  
AmanyH Mansour ◽  
Maha Ragab
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Human Platelets ◽  
Depressed Patients
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