Sensitivity to reward and punishment and the prefrontal cortex in major depression

2006 ◽  
Vol 90 (2-3) ◽  
pp. 209-215 ◽  
Author(s):  
Anita Must ◽  
Zoltán Szabó ◽  
Nikoletta Bódi ◽  
Anna Szász ◽  
Zoltán Janka ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Major Depression ◽  
Sensitivity To Reward ◽  
Reward And Punishment

scholarly journals Age-Dependent Reductions in the Level of Glial Fibrillary Acidic Protein in the Prefrontal Cortex in Major Depression

2004 ◽  
Vol 29 (11) ◽  
pp. 2088-2096 ◽  
Author(s):  
Xiaohong Si ◽  
Jose Javier Miguel-Hidalgo ◽  
Gillian O'Dwyer ◽  
Craig A Stockmeier ◽  
Grazyna Rajkowska
Keyword(s):  
Prefrontal Cortex ◽  
Major Depression ◽  
Glial Fibrillary Acidic Protein ◽  
Acidic Protein ◽  
Age Dependent

Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression

2003 ◽  
Vol 53 (5) ◽  
pp. 376-384 ◽  
Author(s):  
Deanna M Barch ◽  
Yvette I Sheline ◽  
John G Csernansky ◽  
Abraham Z Snyder
Keyword(s):  
Working Memory ◽  
Prefrontal Cortex ◽  
Major Depression

scholarly journals Amygdala inputs to prefrontal cortex guide behavior amid conflicting cues of reward and punishment

2017 ◽  
Vol 20 (6) ◽  
pp. 824-835 ◽  
Author(s):  
Anthony Burgos-Robles ◽  
Eyal Y Kimchi ◽  
Ehsan M Izadmehr ◽  
Mary Jane Porzenheim ◽  
William A Ramos-Guasp ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Reward And Punishment

scholarly journals Impaired Subcortical Detection of Auditory Changes in Schizophrenia but Not in Major Depression

2019 ◽  
Vol 46 (1) ◽  
pp. 193-201 ◽  
Author(s):  
Arnim Johannes Gaebler ◽  
Jana Zweerings ◽  
Jan Willem Koten ◽  
Andrea Anna König ◽  
Bruce I Turetsky ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Major Depression ◽  
Auditory Processing ◽  
Region Of Interest ◽  
Auditory Pathway ◽  
Consistent Finding ◽  
Healthy Control ◽  
Patient Groups ◽  
Processing Deficits ◽  
Cortical Dysfunction

Abstract The mismatch negativity is a cortical response to auditory changes and its reduction is a consistent finding in schizophrenia. Recent evidence revealed that the human brain detects auditory changes already at subcortical stages of the auditory pathway. This finding, however, raises the question where in the auditory hierarchy the schizophrenic deficit first evolves and whether the well-known cortical deficit may be a consequence of dysfunction at lower hierarchical levels. Finally, it should be resolved whether mismatch profiles differ between schizophrenia and affective disorders which exhibit auditory processing deficits as well. We used functional magnetic resonance imaging to assess auditory mismatch processing in 29 patients with schizophrenia, 27 patients with major depression, and 31 healthy control subjects. Analysis included whole-brain activation, region of interest, path and connectivity analysis. In schizophrenia, mismatch deficits emerged at all stages of the auditory pathway including the inferior colliculus, thalamus, auditory, and prefrontal cortex. In depression, deficits were observed in the prefrontal cortex only. Path analysis revealed that activation deficits propagated from subcortical to cortical nodes in a feed-forward mechanism. Finally, both patient groups exhibited reduced connectivity along this processing stream. Auditory mismatch impairments in schizophrenia already manifest at the subcortical level. Moreover, subcortical deficits contribute to the well-known cortical deficits and show specificity for schizophrenia. In contrast, depression is associated with cortical dysfunction only. Hence, schizophrenia and major depression exhibit different neural profiles of sensory processing deficits. Our findings add to a converging body of evidence for brainstem and thalamic dysfunction as a hallmark of schizophrenia.

scholarly journals Sex differences in pubertal associations with fronto-accumbal white matter morphometry: Implications for understanding sensitivity to reward and punishment

NeuroImage ◽  
2021 ◽  
Vol 226 ◽  
pp. 117598
Author(s):  
Rajpreet Chahal ◽  
Kristen Delevich ◽  
Jaclyn S. Kirshenbaum ◽  
Lauren R. Borchers ◽  
Tiffany C. Ho ◽  
...  
Keyword(s):  
Sex Differences ◽  
White Matter ◽  
Sensitivity To Reward ◽  
Reward And Punishment
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