The effects of high-dose vitamin E supplementation on biomarkers of kidney injury, inflammation, and oxidative stress in patients with diabetic nephropathy: A randomized, double-blind, placebo-controlled trial

2016 ◽  
Vol 10 (4) ◽  
pp. 922-929 ◽  
Author(s):  
Parisa Golriz Khatami ◽  
Alireza Soleimani ◽  
Nasrin Sharifi ◽  
Esmat Aghadavod ◽  
Zatollah Asemi
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Controlled Trial ◽  
Kidney Injury ◽  
High Dose ◽  
Double Blind ◽  
Double Blind Placebo ◽  
And Oxidative Stress ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

scholarly journals The effects of selenium supplementation on biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy: a randomised, double-blind, placebo-controlled trial

2016 ◽  
Vol 116 (7) ◽  
pp. 1222-1228 ◽  
Author(s):  
Fereshteh Bahmani ◽  
Mahsa Kia ◽  
Alireza Soleimani ◽  
Ali Akbar Mohammadi ◽  
Zatollah Asemi
Keyword(s):  
Oxidative Stress ◽  
Diabetic Nephropathy ◽  
Transforming Growth Factor ◽  
Controlled Trial ◽  
Matrix Metalloproteinase 2 ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Hs Crp ◽  
And Oxidative Stress

AbstractThis study was carried out to assess the effects of Se supplementation on biomarkers of inflammation and oxidative stress in patients with diabetic nephropathy (DN). This randomised, double-blind, placebo-controlled clinical trial was conducted among sixty patients with DN. Patients were randomly divided into two groups to take either 200 µg/d Se supplements as Se yeast (n 30) or placebo (n 30) for 12 weeks. In unadjusted analyses, compared with the placebo, Se supplementation led to a significant reduction in high-sensitivity C-reactive protein (hs-CRP) (−1069·2 (sd 1752·2) v. −135·3 (sd 1258·9) ng/ml, P=0·02), matrix metalloproteinase-2 (MMP-2) (−612·3 (sd 679·6) v. +76·0 (sd 309·1) ng/ml, P<0·001) and plasma malondialdehyde (MDA) concentrations (−0·1 (sd 0·7) v. +0·4 (sd 0·9) µmol/l, P=0·01). In addition, a significant increase in plasma total antioxidant capacity (TAC) (+174·9 (sd 203·9) v. +15·8 (sd 382·2) mmol/l, P=0·04) was observed following supplementation with Se compared with the placebo. Subjects who received Se supplements experienced a borderline statistically significant decrease in serum protein carbonyl (PCO) levels (P=0·06) compared with the placebo. When we adjusted the analysis for baseline values of biochemical parameters, age and BMI, serum hs-CRP (P=0·14) and MDA levels (P=0·16) became non-significant, whereas plasma nitric oxide (NO) (P=0·04) and glutathione (GSH) (P<0·001) became statistically significant, and other findings did not change. Supplementation with Se had no significant effect on NO, transforming growth factor β (TGF-β), advanced glycation end products (AGE), PCO and GSH compared with the placebo. Overall, our study demonstrated that Se supplementation among DN patients had favourable effects on serum MMP-2, plasma NO, TAC and GSH, but did not affect hs-CRP, TGF-β, AGE, PCO and MDA.

scholarly journals High-dose vitamin D 3 reduces circulating hepcidin concentrations: A pilot, randomized, double-blind, placebo-controlled trial in healthy adults

2017 ◽  
Vol 36 (4) ◽  
pp. 980-985 ◽  
Author(s):  
Ellen M. Smith ◽  
Jessica A. Alvarez ◽  
Malcolm D. Kearns ◽  
Li Hao ◽  
John H. Sloan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Controlled Trial ◽  
Healthy Adults ◽  
High Dose ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Vitamin D 3 ◽  
High Dose Vitamin
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