Protease-activated receptor 2–dependent fluid secretion from airway submucosal glands by house dust mite extract

2012 ◽  
Vol 129 (2) ◽  
pp. 529-535.e5 ◽  
Author(s):  
Hyung-Ju Cho ◽  
Hyun Jae Lee ◽  
Sang Cheol Kim ◽  
Kyubo Kim ◽  
Yoo Suk Kim ◽  
...  
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Fluid Secretion ◽  
Mite Extract ◽  
Submucosal Glands ◽  
Dust Mite ◽  
Protease Activated Receptor 2 ◽  
House Dust Mite Extract

scholarly journals Crucial role of stimulator of interferon genes-dependent signaling in house dust mite extract-induced IgE production

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hiroki Nunokawa ◽  
Yusuke Murakami ◽  
Takashi Ishii ◽  
Tomoya Narita ◽  
Haruyuki Ishii ◽  
...  
Keyword(s):  
B Cell ◽  
House Dust ◽  
House Dust Mite ◽  
Tfh Cells ◽  
Specific Serum ◽  
Mite Extract ◽  
Dust Mite ◽  
Cell Proportion ◽  
House Dust Mite Extract

AbstractStimulator of interferon genes (STING) is a DNA sensor that responds to pathogens and induces type I interferon production. Herein, the role of STING in house dust mite extract (HDM)-induced allergic asthma was investigated. C57BL/6 wild-type (WT) and Sting−/− mice were intratracheally sensitized with HDM, and the bronchoalveolar lavage fluid (BALF), sera, lungs, and mediastinal lymph nodes (MLNs) were analyzed. The total and HDM-specific serum IgE levels were lower in Sting−/− mice than in WT mice. B cell and IgE-positive B cell proportion in BALF and MLNs, respectively, was significantly lower in Sting−/− mice than in WT mice. Additionally, cyclic GMP-AMP, a STING ligand, augmented total and HDM-specific serum IgE levels and B cell proportion in BALF when applied in combination with HDM. To elucidate the role of STING in IgE production, follicular helper T (Tfh) cells, which are involved in B cell maturation, were investigated. Tfh cell proportion in MLNs decreased in Sting−/− mice, and IL-4 and IL-13 production by HDM-restimulated MLN cells from HDM-sensitized mice was decreased in Sting−/− mice compared with WT mice. Thus, STING plays an important role in the maturation and class switching of IgE-producing B cells in allergic inflammation via Tfh cells.

scholarly journals Oral immunotherapy with the ingestion of house dust mite extract in a murine model of allergic asthma

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Yao-Tung Wang ◽  
Hsu-Chung Liu ◽  
Hui-Chen Chen ◽  
Yen-Ching Lee ◽  
Tung-Chou Tsai ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
House Dust ◽  
House Dust Mite ◽  
Murine Model ◽  
Oral Immunotherapy ◽  
Mite Extract ◽  
Dust Mite ◽  
House Dust Mite Extract

scholarly journals House Dust Mite Extract Induces Interleukin-9 Expression in Human Eosinophils

2008 ◽  
Vol 57 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Takao Fujisawa ◽  
Hajime Katsumata ◽  
Yoshiko Kato
Keyword(s):  
House Dust ◽  
House Dust Mite ◽  
Mite Extract ◽  
Dust Mite ◽  
Interleukin 9 ◽  
House Dust Mite Extract

scholarly journals Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre‐school children

Allergy ◽  
2019 ◽  
Vol 74 (4) ◽  
pp. 780-787 ◽  
Author(s):  
Marta Ponce ◽  
Fabian Schroeder ◽  
Christina Bannert ◽  
Klara Schmidthaler ◽  
Christian Skjødt Hansen ◽  
...  
Keyword(s):  
School Children ◽  
House Dust ◽  
House Dust Mite ◽  
Sublingual Immunotherapy ◽  
Mite Extract ◽  
Dust Mite ◽  
House Dust Mite Extract
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