Lower Airway Inflammation Assessed by Induced Sputum in a Cluster of Cases Suggestive of Organic Dust Toxic Syndrome

2007 ◽  
Vol 119 (1) ◽  
pp. S268
Author(s):  
R. Castano ◽  
J.L. Malo ◽  
C. Lemiere ◽  
M. Labrecque ◽  
A. Cartier
Keyword(s):  
Airway Inflammation ◽  
Induced Sputum ◽  
Lower Airway ◽  
Organic Dust ◽  
Organic Dust Toxic Syndrome

Equine asthma: managing the environment

UK-Vet Equine ◽  
2019 ◽  
Vol 3 (3) ◽  
pp. 78-84 ◽  
Author(s):  
Joel William Hotchkiss
Keyword(s):  
Environmental Management ◽  
Airway Obstruction ◽  
Airway Inflammation ◽  
Airway Disease ◽  
Lower Airway ◽  
Recurrent Airway Obstruction ◽  
Organic Dust ◽  
Inflammatory Airway Disease ◽  
Equine Asthma ◽  
Environmental Challenge

Equine asthma is an umbrella term defined by nonseptic lower airway inflammation. Currently there are two broad categories, namely mild to moderate equine asthma (formerly known as inflammatory airway disease) and severe equine asthma (formerly known as recurrent airway obstruction or heaves). Environmental challenge is involved in the aetiopathogenesis of both these subcategories. Much of this challenge, and the part that we can control, is provided by the organic dust associated with the stabling of horses. This article reviews the available evidence relating to the environmental management of equine asthma and tries to relate this to practical options for providing a low-dust environment.

Incidence of Organic Dust Toxic Syndrome and Allergic Alveolitis in Swedish Farmers

1988 ◽  
Vol 87 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Per Malmberg ◽  
Anna Rask-Andersen ◽  
Sverker Höglund ◽  
Birgitta Kolmodin-Hedman ◽  
Judith Read Guernsey
Keyword(s):  
Organic Dust ◽  
Allergic Alveolitis ◽  
Organic Dust Toxic Syndrome

scholarly journals POSSIBILITIES OF CYTOLOGICAL AND IMMUNOCYTOCHEMICAL MARKERSOF INDUCED SPUTUM IN THE EVALUATION OF AIRWAY INFLAMMATION IN PATIENTSWITH DIFFERENT LEVELS OF ASTHMA CONTROL

2015 ◽  
Vol 7 (2) ◽  
pp. 68-73
Author(s):  
S N Pospelova ◽  
S A Sobchenko ◽  
V Yu Kravtsov
Keyword(s):  
Airway Inflammation ◽  
Asthma Control ◽  
Induced Sputum ◽  
Objective Indicator ◽  
Control Objective ◽  
Different Levels

Were analyzed cytological and immunocytochemical data of induced sputum 43 patients with dif- ferent levels of asthma controlResults of cytological research showed lack or presence of eosinophilic airway inflammation (rela- tive number of eosinophils> 3%), but were not helpful in distinguishing uncontrolled from partially controlled asthma, these data could not be used for determination of level of asthma control. Objective indicator of the severity of airway inflammation, significantly correlated with the levels of disease con- trol, is the ratio of IL-1Ra/IL-1 in AM.

scholarly journals Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases

2017 ◽  
Vol 312 (5) ◽  
pp. L678-L687 ◽  
Author(s):  
Sandra Hodge ◽  
Hai B. Tran ◽  
Rhys Hamon ◽  
Eugene Roscioli ◽  
Greg Hodge ◽  
...  
Keyword(s):  
Airway Inflammation ◽  
Lung Diseases ◽  
Bacterial Resistance ◽  
Scavenger Receptor ◽  
Lower Airway ◽  
Chronic Obstructive ◽  
Apoptotic Cells ◽  
Nontypeable Haemophilus Influenzae ◽  
Pyrin Domain ◽  
Chronic Lung Diseases

We reported defective efferocytosis associated with cigarette smoking and/or airway inflammation in chronic lung diseases, including chronic obstructive pulmonary disease, severe asthma, and childhood bronchiectasis. We also showed defects in phagocytosis of nontypeable Haemophilus influenzae (NTHi), a common colonizer of the lower airway in these diseases. These defects could be substantially overcome with low-dose azithromycin; however, chronic use may induce bacterial resistance. The aim of the present study was therefore to investigate two novel macrolides—2′-desoxy-9-(S)-erythromycylamine (GS-459755) and azithromycin-based 2′-desoxy molecule (GS-560660)—with significantly diminished antibiotic activity against Staphylococcus aureus, Streptococcus pneumonia, Moraxella catarrhalis, and H. influenzae. We tested their effects on efferocytosis, phagocytosis of NTHi, cell viability, receptors involved in recognition of apoptotic cells and/or NTHi (flow cytometry), secreted and cleaved intracellular IL-1β (cytometric bead array, immunofluorescence/confocal microscopy), and nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) using primary alveolar macrophages and THP-1 macrophages ± 10% cigarette smoke extract. Dose-response experiments showed optimal prophagocytic effects of GS-459755 and GS-560660 at concentrations of 0.5–1 µg/ml compared with our findings with azithromycin. Both macrolides significantly improved phagocytosis of apoptotic cells and NTHi (e.g., increases in efferocytosis and phagocytosis of NTHi: GS-459755, 23 and 22.5%, P = 0.043; GS-560660, 23.5 and 22%, P = 0.043, respectively). Macrophage viability remained >85% following 24 h exposure to either macrolide at concentrations up to 20 µg/ml. Secreted and intracellular-cleaved IL-1β was decreased with both macrolides with no significant changes in recognition molecules c-mer proto-oncogene tyrosine kinase; scavenger receptor class A, member 1; Toll-like receptor 2/4; or CD36. Particulate cytoplasmic immunofluorescence of NLRP3 inflammasome was also reduced significantly. We conclude that GS-459755 and GS-560660 may be useful for reducing airway inflammation in chronic lung diseases without inducing bacterial resistance.

Association of lower airway inflammation with physiologic findings in young children with cystic fibrosis

2009 ◽  
Vol 44 (5) ◽  
pp. 503-511 ◽  
Author(s):  
Stacey L. Peterson-Carmichael ◽  
William T. Harris ◽  
Ruchika Goel ◽  
Terry L. Noah ◽  
Robin Johnson ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Young Children ◽  
Airway Inflammation ◽  
Lower Airway
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