Bronchial Thermoplasty in Refractory Asthma: Interim Results in a Severe Asthma Population (Research in Severe Asthma (RISA) Trial)

2007 ◽  
Vol 119 (1) ◽  
pp. S1 ◽  
Author(s):  
R. Niven ◽  
I. Pavord ◽  
M. Laviolette ◽  
N. Thomson ◽  
P. Corris ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Population Research ◽  
Bronchial Thermoplasty ◽  
Refractory Asthma

scholarly journals Bronchial Thermoplasty in the Treatment of Severe Asthma

2020 ◽  
pp. 1-9
Author(s):  
Nightingale Syabbalo ◽  
Keyword(s):  
Severe Asthma ◽  
Inhaled Corticosteroids ◽  
Airway Disease ◽  
Airflow Limitation ◽  
Response To Treatment ◽  
High Dose ◽  
Eosinophilic Asthma ◽  
Bronchial Thermoplasty ◽  
Long Acting ◽  
Refractory Asthma

Asthma is a chronic inflammatory airway disease with several distinct phenotypes, characterized by different immunopathological pathways, clinical presentation, severity of the disease, and response to treatment. The phenotypes of asthma include eosinophilic, neutrophilic, mixed granulocytic, and paucigranulocytic asthma. Approximately 3.6-10% of patients with asthma have severe refractory disease, which is unresponsive to high dose inhaled corticosteroids (ICS), and long-acting β2-agonists (LABA). Most patients with eosinophilic asthma are responsive to corticosteroids, and interleukintargeted biologics, whereas, patients from other phenotypes, such as neutrophillic and paucigranullocytic asthma are resistant to treatment with ICS and biotherapeutics. The hallmark of severe refractory asthma is airway hyperresponsiveness, and remodeling. Histopathologically, patients with severe asthma have airway smooth muscle (ASM) hyperplasia and hypertrophy; subepithelial basement membrane thickening and fibrosis; all which contribute to fixed airflow limitation. Severe refractory asthma is very difficult to treat pharmacologically. It requires innovative therapies, such as bronchial thermoplasty which reduces the hypertrophied ASM mass and relieves the AHR, and broncoconstriction. Bronchial thermoplasty has been shown to improve asthma control, reduce severe exacerbations, hospitalizations, emergency room visits, and improve the quality of life, which persist up to 5 years following the procedure

scholarly journals Bronchial thermoplasty reduces gas trapping in severe asthma

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
David Langton ◽  
Alvin Ing ◽  
Kim Bennetts ◽  
Wei Wang ◽  
Claude Farah ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Bronchial Thermoplasty ◽  
Gas Trapping

scholarly journals Evaluation of expiratory capacity with severe asthma following bronchial thermoplasty

2018 ◽  
Vol 7 (1) ◽  
pp. e00387 ◽  
Author(s):  
Satoru Ishii ◽  
Motoyasu Iikura ◽  
Yukiko Shimoda ◽  
Shinyu Izumi ◽  
Masayuki Hojo ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Bronchial Thermoplasty

scholarly journals A multicenter study on the safety and efficacy of bronchial thermoplasty in adults with severe asthma

Lung India ◽  
2021 ◽  
Vol 38 (6) ◽  
pp. 524
Author(s):  
Karan Madan ◽  
TejasM Suri ◽  
Saurabh Mittal ◽  
VenkataNagarjuna Maturu ◽  
VR Pattabhiraman ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Multicenter Study ◽  
Safety And Efficacy ◽  
Bronchial Thermoplasty

scholarly journals Bronchial Thermoplasty-Induced Acute Airway Effects Assessed with Optical Coherence Tomography in Severe Asthma

Respiration ◽  
2018 ◽  
Vol 96 (6) ◽  
pp. 564-570 ◽  
Author(s):  
Annika W.M. Goorsenberg ◽  
Julia N.S. d’Hooghe ◽  
Daniel M. de Bruin ◽  
Inge A.H. van den Berk ◽  
Jouke T. Annema ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Severe Asthma ◽  
Optical Coherence ◽  
Bronchial Thermoplasty

Quantitative CT detects changes in airway dimensions and air-trapping after bronchial thermoplasty for severe asthma

2018 ◽  
Vol 107 ◽  
pp. 33-38 ◽  
Author(s):  
Philip Konietzke ◽  
Oliver Weinheimer ◽  
Mark O. Wielpütz ◽  
Willi L. Wagner ◽  
Philine Kaukel ◽  
...  
Keyword(s):  
Severe Asthma ◽  
Quantitative Ct ◽  
Air Trapping ◽  
Bronchial Thermoplasty ◽  
Airway Dimensions
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