Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1

2007 ◽  
Vol 119 (4) ◽  
pp. 937-943 ◽  
Author(s):  
Tamar Kinaciyan ◽  
Beatrice Jahn-Schmid ◽  
Astrid Radakovics ◽  
Bettina Zwölfer ◽  
Claudia Schreiber ◽  
...  
Keyword(s):  
Immune Response ◽  
Food Allergy ◽  
Sublingual Immunotherapy ◽  
Birch Pollen ◽  
Bet V 1 ◽  
Mal D 1

Efficacy and safety of 4 months of sublingual immunotherapy with recombinant Mal d 1 and Bet v 1 in patients with birch pollen–related apple allergy

2018 ◽  
Vol 141 (3) ◽  
pp. 1002-1008 ◽  
Author(s):  
Tamar Kinaciyan ◽  
Birgit Nagl ◽  
Sandra Faustmann ◽  
Florian Frommlet ◽  
Stephan Kopp ◽  
...  
Keyword(s):  
Sublingual Immunotherapy ◽  
Birch Pollen ◽  
Efficacy And Safety ◽  
Bet V 1 ◽  
Mal D 1

scholarly journals Difference in accumulation pattern of the allergens within the same PR10 family in transgenic rice

2018 ◽  
Author(s):  
Fumio Takaiwa ◽  
Yuko Ogo ◽  
Yuhya Wakasa
Keyword(s):  
Transgenic Rice ◽  
Birch Pollen ◽  
Secretory Protein ◽  
Aleurone Layer ◽  
Accumulation Pattern ◽  
Vegetative Tissues ◽  
Bet V 1 ◽  
Birch Pollen Allergen ◽  
Mal D 1 ◽  
Post Transcriptional Regulation

AbstractApple food allergen Mal d 1 and birch pollen allergen Bet v 1 belong to the same pathogen related protein 10 (PR10) family. When each of these allergens was expressed as a secretory protein by fusion with the GFP reporter in transgenic rice by ligating an N terminal signal peptide and a C terminal KDEL ER retention signal under the control of the maize ubiquitin constitutive promoter, the GFP:Mald1 highly accumulated in various tissues, whereas the accumulation level of GFP:Betv1 was remarkably reduced in vegetative tissues except for seed. Analysis by RT-PCR exhibited that there was little difference in transcript levels between them, indicating the involvement of post-transcriptional regulation. To investigate the cause of such difference in accumulation levels, deletion analysis of the Mal d 1 and domain swapping between them were carried out in transgenic rice. These results showed that the region between positions 41-90 in the Mal d 1 is predominantly implicated in higher level accumulation in vegetative tissues as well as seed compared with the Bet v 1. It is notable that GFP:Mald1 directed by the ubiquitin promoter is deposited in huge PBs in aleurone layer rather than starchy endosperm.HighlightSpecific region of PR10 proteins is mainly implicated in their stability in vegetative tissues when expressed in transgenic rice.

Oral exposure to Mal d 1 affects the immune response in patients with birch pollen allergy

2013 ◽  
Vol 131 (1) ◽  
pp. 94-102 ◽  
Author(s):  
Marija Geroldinger-Simic ◽  
Tamar Kinaciyan ◽  
Birgit Nagl ◽  
Ursula Baumgartner-Durchschlag ◽  
Hans Huber ◽  
...  
Keyword(s):  
Immune Response ◽  
Birch Pollen ◽  
Pollen Allergy ◽  
Oral Exposure ◽  
Birch Pollen Allergy ◽  
Mal D 1
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