Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle

2006 ◽  
Vol 118 (3) ◽  
pp. 641-648 ◽  
Author(s):  
M SUKKAR ◽  
S XIE ◽  
N KHORASANI ◽  
O KON ◽  
R STANBRIDGE ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Toll Like Receptor ◽  
Human Airway Smooth Muscle ◽  
Human Airway ◽  
Toll Like Receptor 2 ◽  
And Function

RNA Interference Decreases PAR-2 Expression and Function in Human Airway Smooth Muscle Cells

2006 ◽  
Vol 34 (1) ◽  
pp. 49-55 ◽  
Author(s):  
Thomas Trian ◽  
Pierre-Olivier Girodet ◽  
Olga Ousova ◽  
Roger Marthan ◽  
J. Manuel Tunon-de-Lara ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Rna Interference ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Muscle Cells ◽  
Airway Smooth Muscle Cells ◽  
Human Airway Smooth Muscle ◽  
Human Airway ◽  
And Function

TNF-α upregulates Giα and Gqα protein expression and function in human airway smooth muscle cells

1999 ◽  
Vol 276 (3) ◽  
pp. L405-L411 ◽  
Author(s):  
Kunihisa Hotta ◽  
Charles W. Emala ◽  
Carol A. Hirshman
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Airway Smooth Muscle ◽  
Muscle Cells ◽  
Signal Transduction Pathways ◽  
Airway Smooth Muscle Cells ◽  
Human Airway Smooth Muscle ◽  
Human Airway ◽  
Tnf Α ◽  
And Function

Chronic inflammation is a characteristic feature of asthma. Multiple inflammatory mediators are released within the asthmatic lung, some of which may have detrimental effects on signal transduction pathways in airway smooth muscle. The effects of tumor necrosis factor (TNF)-α on the expression and function of muscarinic receptors and guanine nucleotide-binding protein (G protein) α-subunits were examined in human airway smooth muscle cells. Cultured human airway smooth muscle cells were incubated in serum-free culture medium for 72 h in the presence and absence of 10 ng/ml of TNF-α, after which the cells were lysed and subjected to electrophoresis and Gαi-2, Gqα, and Gsα protein subunits were detected by immunoblot analysis with specific antisera. TNF-α treatment for 72 h significantly increased the expression of Gαi-2 and Gqα proteins and enhanced carbachol (10−7 M)-mediated inhibition of adenylyl cyclase activity and inositol phosphate synthesis. These data provide new evidence demonstrating that TNF-α not only increases expression of Gαi-2 and Gqα proteins but also augments the associated signal transduction pathways that would facilitate increased tone of airway smooth muscle.

scholarly journals Expression and Function of Voltage-dependent Potassium Channel Genes in Human Airway Smooth Muscle

1996 ◽  
Vol 271 (22) ◽  
pp. 13239-13243 ◽  
Author(s):  
Sarvesh Adda ◽  
Bernd K. Fleischmann ◽  
Bruce D. Freedman ◽  
Ming-fu Yu ◽  
Douglas W. P. Hay ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Potassium Channel ◽  
Airway Smooth Muscle ◽  
Human Airway Smooth Muscle ◽  
Human Airway ◽  
Voltage Dependent ◽  
And Function

Kisspeptins Expression and Function in Asthmatic Human Airway Smooth Muscle

2019 ◽  
Author(s):  
N.A. Borkar ◽  
R.S.R. Kalidhindi ◽  
N.S. Ambhore ◽  
J. Loganathan ◽  
C.M. Pabelick ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Human Airway Smooth Muscle ◽  
Human Airway ◽  
And Function

scholarly journals Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle

2019 ◽  
Vol 33 (8) ◽  
pp. 9008-9016 ◽  
Author(s):  
Tonio Pera ◽  
Eric Tompkins ◽  
Michael Katz ◽  
Bin Wang ◽  
Deepak A. Deshpande ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Human Airway Smooth Muscle ◽  
Gpcr Signaling ◽  
Human Airway ◽  
And Function
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