Cabbage lipid transfer protein Bra o 3 is a major allergen responsible for cross-reactivity between plant foods and pollens

2006 ◽  
Vol 117 (6) ◽  
pp. 1423-1429 ◽  
Author(s):  
A PALACIN ◽  
J CUMPLIDO ◽  
J FIGUEROA ◽  
O AHRAZEM ◽  
R SANCHEZMONGE ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Major Allergen ◽  
Cross Reactivity ◽  
Lipid Transfer ◽  
Plant Foods ◽  
Transfer Protein

Cabbage Lipid Transfer Protein Bra o 3 is a Major Allergen Responsible for Cross-Reactivity between Plant Foods and Pollens

2006 ◽  
Vol 117 (2) ◽  
pp. S302
Author(s):  
J. Cumplido ◽  
A. Palacín ◽  
J. Figueroa ◽  
O. Ahrazem ◽  
R. Sánchez-Monge ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Major Allergen ◽  
Cross Reactivity ◽  
Lipid Transfer ◽  
Plant Foods ◽  
Transfer Protein

scholarly journals LTP Allergy Follow-Up Study: Development of Allergy to New Plant Foods 10 Years Later

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2165
Author(s):  
Diana Betancor ◽  
Alicia Gomez-Lopez ◽  
Carlos Villalobos-Vilda ◽  
Emilio Nuñez-Borque ◽  
Sergio Fernández-Bravo ◽  
...  
Keyword(s):  
Food Allergy ◽  
Lipid Transfer Protein ◽  
Specific Ige ◽  
Cross Reactivity ◽  
Allergic Reactions ◽  
Plant Food ◽  
Lipid Transfer ◽  
Plant Foods ◽  
Transfer Protein

Introduction: Allergy to nonspecific lipid transfer protein (nsLTP) is the main cause of plant-food allergy in Spain. nsLTPs are widely distributed in the plant kingdom and have high cross-reactivity but extremely variable clinical expression. Little is known about the natural evolution of this allergy, which complicates management. The objective of this study was to assess the development of allergy to new plant foods in nsLTP-sensitized patients 10 years after diagnosis. Methods: One hundred fifty-one patients showing specific IgE to nsLTP determined by ISAC (Thermofisher) were included. After clinical workup (i.e., anamnesis, skin test, and challenge when needed), these patients were divided into two groups: 113 patients allergic to one or more plant food (74.5%) and 38 patients not allergic to any plant food (25.1%). Ten years later, a telephone interview was conducted to check whether patients had developed additional allergic reactions to plant foods. Results: Ten years after diagnosis, 35 of the 113 (31%) plant-food-allergic patients sensitized to nsLTP reported reactions to new, previously tolerated plant foods, mainly Rosaceae/Prunoideae fruits and nuts followed by vegetables, Rosacea/Pomoideae fruits, legumes, and cereals. Five out of 38 (13.2%) patients previously sensitized to nsLTP but without allergy to any plant food had experienced allergic reactions to some plant food: two to Rosaceae/Prunoideae fruits, two to Rosaceae/Prunoideae fruit and nuts, and one to legumes. Conclusion: Patients sensitized to nsLTP developed allergic reactions to other plant foods, mainly Rosaceae-Prunoideae fruits and nuts. This was more frequent among plant-food-allergic patients than among those who had never had plant-food allergy.

Plant Lipid Transfer Protein Allergens: No Cross-Reactivity between Those from Foods and Olive and Parietaria Pollen

2011 ◽  
Vol 156 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Leticia Tordesillas ◽  
Sofía Sirvent ◽  
Araceli Díaz-Perales ◽  
Mayte Villalba ◽  
Javier Cuesta-Herranz ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Cross Reactivity ◽  
Lipid Transfer ◽  
Plant Lipid ◽  
Transfer Protein

Cloning and Characterization of Walnut Lipid Transfer Protein: Not a Major Allergen in Walnut-Allergic U.S. Patients

2006 ◽  
Vol 117 (2) ◽  
pp. S43 ◽  
Author(s):  
S.S. Teuber ◽  
E. Pastorello ◽  
W.R. Peterson ◽  
A.M. Dandekar ◽  
S. Uratsu
Keyword(s):  
Lipid Transfer Protein ◽  
Major Allergen ◽  
Lipid Transfer ◽  
Transfer Protein

Evidence for a lipid transfer protein as the major allergen of apricot

2000 ◽  
Vol 105 (2) ◽  
pp. 371-377 ◽  
Author(s):  
Elide A. Pastorello ◽  
Francesco Purello D’Ambrosio ◽  
Valerio Pravettoni ◽  
Laura Farioli ◽  
Gabriella Giuffrida ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Major Allergen ◽  
Lipid Transfer ◽  
Transfer Protein

scholarly journals Sensitization Prevalence, Antibody Cross-Reactivity and Immunogenic Peptide Profile of Api g 2, the Non-Specific Lipid Transfer Protein 1 of Celery

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e24150 ◽  
Author(s):  
Gabriele Gadermaier ◽  
Michael Hauser ◽  
Matthias Egger ◽  
Rosetta Ferrara ◽  
Peter Briza ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Cross Reactivity ◽  
Lipid Transfer ◽  
Peptide Profile ◽  
Transfer Protein ◽  
Immunogenic Peptide ◽  
Specific Lipid

scholarly journals Energy Landscapes of Ligand Motion Inside the Tunnel-Like Cavity of Lipid Transfer Proteins: The Case of the Pru p 3 Allergen

2019 ◽  
Vol 20 (6) ◽  
pp. 1432
Author(s):  
Bruno Cuevas-Zuviría ◽  
María Garrido-Arandia ◽  
Araceli Díaz-Perales ◽  
Luis Pacios
Keyword(s):  
Lipid Transfer Protein ◽  
Protein A ◽  
Major Allergen ◽  
Cross Reactivity ◽  
Food Sources ◽  
Carrier Protein ◽  
Binding Modes ◽  
Lipid Transfer ◽  
Collective Variables ◽  
Pru P 3

Allergies are a widespread problem in western countries, affecting a large part of the population, with levels of prevalence increasingly rising due to reasons still not understood. Evidence accumulated in recent years points to an essential role played by ligands of allergen proteins in the sensitization phase of allergies. In this regard, we recently identified the natural ligand of Pru p 3, a lipid transfer protein, a major allergen from peach fruit and a model of food allergy. The ligand of Pru p 3 has been shown to play a key role in the sensitization to peach and to other plant food sources that provoke cross-reactivity in a large proportion of patients allergic to peach. However, the question of which is the binding pose of this ligand in its carrier protein, and how it can be transferred to receptors of the immune system where it develops its function as a coadjuvant was not elucidated. In this work, different molecular dynamics simulations have been considered as starting points to study the properties of the ligand–protein system in solution. Besides, an energy landscape based on collective variables that describe the process of ligand motion within the cavity of Pru p 3 was obtained by using well-tempered metadynamics. The simulations revealed the differences between distinct binding modes, and also revealed important aspects of the motion of the ligand throughout its carrier protein, relevant to its binding–unbinding process. Our findings are potentially interesting for studying protein–ligand systems beyond the specific case of the allergen protein dealt with here.

Hypoallergenic Variants of the Parietaria judaica Major Allergen Par j 1: A Member of the Non-Specific Lipid Transfer Protein Plant Family

2001 ◽  
Vol 126 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Angela Bonura ◽  
Saverio Amoroso ◽  
Giovanni Locorotondo ◽  
Gabriella Di Felice ◽  
Raffaella Tinghino ◽  
...  
Keyword(s):  
Lipid Transfer Protein ◽  
Major Allergen ◽  
Lipid Transfer ◽  
Plant Family ◽  
Transfer Protein ◽  
Specific Lipid
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