Novel plant pathogenesis-related protein family involved in food allergy

2004 ◽  
Vol 114 (4) ◽  
pp. 896-899 ◽  
Author(s):  
Teresa Asensio ◽  
Jesus F. Crespo ◽  
Rosa Sanchez-Monge ◽  
Gema Lopez-Torrejon ◽  
Maria L. Somoza ◽  
...  
Keyword(s):  
Food Allergy ◽  
Protein Family ◽  
Related Protein ◽  
Pathogenesis Related Protein ◽  
Pathogenesis Related ◽  
Plant Pathogenesis

scholarly journals Current Overview of Allergens of Plant Pathogenesis Related Protein Families

2014 ◽  
Vol 2014 ◽  
pp. 1-19 ◽  
Author(s):  
Mau Sinha ◽  
Rashmi Prabha Singh ◽  
Gajraj Singh Kushwaha ◽  
Naseer Iqbal ◽  
Avinash Singh ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cross Reactivity ◽  
Amino Acid Sequences ◽  
Pr Proteins ◽  
Antigenic Determinants ◽  
Related Protein ◽  
Protein Families ◽  
Pathogenesis Related Protein ◽  
Pathogenesis Related ◽  
Plant Pathogenesis

Pathogenesis related (PR) proteins are one of the major sources of plant derived allergens. These proteins are induced by the plants as a defense response system in stress conditions like microbial and insect infections, wounding, exposure to harsh chemicals, and atmospheric conditions. However, some plant tissues that are more exposed to environmental conditions like UV irradiation and insect or fungal attacks express these proteins constitutively. These proteins are mostly resistant to proteases and most of them show considerable stability at low pH. Many of these plant pathogenesis related proteins are found to act as food allergens, latex allergens, and pollen allergens. Proteins having similar amino acid sequences among the members of PR proteins may be responsible for cross-reactivity among allergens from diverse plants. This review analyzes the different pathogenesis related protein families that have been reported as allergens. Proteins of these families have been characterized in regard to their biological functions, amino acid sequence, and cross-reactivity. The three-dimensional structures of some of these allergens have also been evaluated to elucidate the antigenic determinants of these molecules and to explain the cross-reactivity among the various allergens.

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