Inhibition of pulmonary inflammation by Roflumilast*1Effects on the time course of cell infiltration, total protein accumulation, and mediator release in OVA-challenged Brown Norway rats

2004 ◽  
Vol 113 (2) ◽  
pp. S218-S219
Author(s):  
R BEUME
Keyword(s):  
Total Protein ◽  
Time Course ◽  
Pulmonary Inflammation ◽  
Mediator Release ◽  
Cell Infiltration ◽  
Brown Norway ◽  
Protein Accumulation ◽  
Norway Rats

scholarly journals Pulmonary Inflammation in Brown Norway Rats: Possible Association of Environmental Particles in the Animal Room Environment

2007 ◽  
Vol 56 (5) ◽  
pp. 319-327 ◽  
Author(s):  
Shinobu NORITAKE ◽  
Koji OGAWA ◽  
Go SUZUKI ◽  
Kazunori OZAWA ◽  
Takuya IKEDA
Keyword(s):  
Pulmonary Inflammation ◽  
Brown Norway ◽  
Norway Rats

scholarly journals Effects of Palm Oil Tocotrienol-Rich Fraction (TRF) and Carotenes in Ovalbumin (OVA)-Challenged Asthmatic Brown Norway Rats

2019 ◽  
Vol 20 (7) ◽  
pp. 1764 ◽  
Author(s):  
Zaida Zainal ◽  
Afiqah Abdul Rahim ◽  
Huzwah Khaza’ai ◽  
Sui Kiat Chang
Keyword(s):  
Palm Oil ◽  
Time Course ◽  
Inflammatory Marker ◽  
Inflammatory Cells ◽  
Lavage Fluid ◽  
Rat Plasma ◽  
Brown Norway ◽  
Therapeutic Drugs ◽  
Potential Benefits ◽  
Norway Rats

Synthetic therapeutic drugs for asthma, a chronic airway inflammation characterised by strong eosinophil, mast cell, and lymphocyte infiltration, mucus hyper-production, and airway hyper-responsiveness, exhibit numerous side effects. Alternatively, the high antioxidant potential of palm oil phytonutrients, including vitamin E (tocotrienol-rich fractions; TRF) and carotene, may be beneficial for alleviating asthma. Here, we determined the therapeutic efficacy of TRF, carotene, and dexamethasone in ovalbumin-challenged allergic asthma in Brown Norway rats. Asthmatic symptoms fully developed within 8 days after the second sensitization, and were preserved throughout the time course via intranasal ovalbumin re-challenge. Asthmatic rats were then orally administered 30 mg/kg body weight TRF or carotene. TRF-treated animals exhibited reduced inflammatory cells in bronchial alveolar lavage fluid. TRF- and carotene-treated rats exhibited notable white blood cell reduction comparable to that from dexamethasone. TRF- and carotene-treatment also downregulated pro-inflammatory markers (IL-β, IL-6, TNF-α), coincident with anti-inflammatory marker IL-4 and IL-13 upregulation. Treatment significantly reduced asthmatic rat plasma CRP and IgE, signifying improved systemic inflammation. Asthmatic lung histology displayed severe edema and inflammatory cell infiltration in the bronchial wall, whereas treated animals retained healthy, normal-appearing lungs. The phytonutrients tocotrienol and carotene thus exhibit potential benefits for consumption as nutritional adjuncts in asthmatic disease.

scholarly journals Aging leads to increased levels of protein O-linked N-acetylglucosamine in heart, aorta, brain and skeletal muscle in Brown-Norway rats

2008 ◽  
Vol 9 (3) ◽  
Author(s):  
Norbert Fülöp ◽  
Wenguang Feng ◽  
Dongqi Xing ◽  
Kai He ◽  
László G. Nőt ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Brown Norway ◽  
Norway Rats
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