scholarly journals GW27-e1103 An Updated Systematic Review and Meta-analysis of the Short- and Long-term Outcomes of Percutaneous Coronary Intervention for Patients with Severe Left Ventricular Systolic Dysfunction

2016 ◽  
Vol 68 (16) ◽  
pp. C88
Author(s):  
Zixiang Yu ◽  
Nuremanguli Abudukeremu ◽  
Siew-Pang Chan ◽  
Yi-Ning Yang ◽  
Xiao-Mei Li ◽  
...  
Keyword(s):  
Left Ventricular Systolic Dysfunction ◽  
Meta Analysis ◽  
Systolic Dysfunction ◽  
Coronary Intervention ◽  
Left Ventricular ◽  
Ventricular Systolic Dysfunction ◽  
Long Term Outcomes ◽  
Percutaneous Coronary ◽  
Short And Long Term

scholarly journals Percutaneous Coronary Intervention versus Coronary Artery Bypass Graft Among Patients with Coronary Artery Disease and Left Ventricular Systolic Dysfunction: a Meta-analysis

2016 ◽  
Vol 6 ◽  
Author(s):  
Fang-Yang Huang ◽  
Bao-Tao Huang ◽  
Yong Peng ◽  
Wei Liu ◽  
Peng-Ju Wang ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Left Ventricular Systolic Dysfunction ◽  
Meta Analysis ◽  
Systolic Dysfunction ◽  
Coronary Intervention ◽  
Left Ventricular ◽  
Percutaneous Coronary ◽  
Artery Disease ◽  
Long Term Mortality

<p>Background: There is an absence of randomized controlled trials (RCTs) comparing types of revascularization in patients with coronary artery disease (CAD) in the presence of left ventricular systolic dysfunction (LVSD).<em> </em>Our aim was to compare the outcomes of percutaneous coronary intervention (PCI) versus coronary artery graft bypass (CABG) among patients with CAD and LVSD.</p><p>Methods: The PubMed online database (from 1976 to November, 2014) and EMbase (from 1974 to November, 2014) were searched. Studies comparing the outcomes of PCI versus CABG among patients with left ventricular dysfunction (ejection fraction &lt;50%) were included. Random- and fixed-effect models were used depending on between-study heterogeneity.</p><p>Results: Due to absence of RCTs on this topic, twelve observational studies including 5,494 patients were included. PCI was associated with a lower risk of short-term mortality (Risk ratio [RR], 0.51, 95% confidence interval [CI], 0.26-1.00) but a higher risk of long-term mortality (RR, 1.21, 95%CI, 1.05-1.40) and repeat revascularization (RR, 4.18, 95%CI, 1.92-9.12) compared with CABG. No significant difference in composite outcomes (RR, 1.26, 95%CI, 0.92-1.73), myocardial infarction (RR, 0.63, 95% CI, 0.17-2.41) and cerebrovascular accident ((RR, 0.61, 95%CI, 0.18-2.01) was observed between PCI vs. CABG.</p><p>Conclusions: Due to the absence of any RCTs on this topic, a meta-analysis of observational studies was performed. It suggested PCI was associated with a better short-term prognosis but an increased risk of long-term mortality compared with CABG. Further well-designed RCT’s are needed to verify this conclusion.</p>

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