scholarly journals GW27-e0550 Microarray Analysis of LncRNA Expression Profile Reveals the Potential Role of LncRNAs in Cardiac Cell Proliferation

2016 ◽  
Vol 68 (16) ◽  
pp. C21
Author(s):  
Jue Wang ◽  
Maoping Chu
Keyword(s):  
Cell Proliferation ◽  
Microarray Analysis ◽  
Expression Profile ◽  
Potential Role ◽  
Cardiac Cell ◽  
Lncrna Expression

scholarly journals Microarray analysis reveals a potential role of LncRNAs expression in cardiac cell proliferation

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Jue Wang ◽  
Zhimin Geng ◽  
Jiakan Weng ◽  
Longjie Shen ◽  
Ming Li ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Microarray Analysis ◽  
Potential Role ◽  
Cardiac Cell

LncRNA expression profile reveals the potential role of lncRNAs in gastric carcinogenesis

2015 ◽  
Vol 15 (3) ◽  
pp. 249-258 ◽  
Author(s):  
Wei Gu ◽  
Tian Gao ◽  
Ying Sun ◽  
Xiong Zheng ◽  
Ji Wang ◽  
...  
Keyword(s):  
Expression Profile ◽  
Potential Role ◽  
Gastric Carcinogenesis ◽  
Lncrna Expression

scholarly journals Hepatic stellate cell proliferation: A potential role of protein kinase R

Hepatology ◽  
2011 ◽  
Vol 54 (4) ◽  
pp. 1484-1485 ◽  
Author(s):  
Sara Ceccarelli ◽  
Nadia Panera ◽  
Anna Alisi ◽  
Valerio Nobili
Keyword(s):  
Cell Proliferation ◽  
Protein Kinase ◽  
Hepatic Stellate Cell ◽  
Potential Role ◽  
Stellate Cell ◽  
Protein Kinase R

PS02.201: EXPRESSION AND ROLE OF CLIC1 IN HUMAN ESOPHAGEAL SQUAMOUS CELL CARCINOMA

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 179-179
Author(s):  
Toshiyuki Kobayashi ◽  
Atsushi Shiozaki ◽  
Hitoshi Fujiwara ◽  
Hirotaka Konishi ◽  
Yoshito Nako ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Microarray Analysis ◽  
Squamous Cell ◽  
Migration And Invasion ◽  
Poor Prognostic Factor ◽  
Weak Expression

Abstract Background Recent studies have reported important roles for chloride intracellular channel 1 (CLIC1) in various cancers; however, its involvement in esophageal squamous cell carcinoma (ESCC) remains unclear. The aim of the present study was to investigate the role of CLIC1 in human ESCC. Methods CLIC1 expression in human ESCC cell lines was analyzed by Western blotting. Knockdown experiments were conducted with CLIC1 siRNA, and their effects on cell proliferation, the cell cycle, apoptosis, migration, and invasion were analyzed. The gene expression profiles of cells were analyzed using a microarray analysis. An immunohistochemical analysis was performed on 61 primary tumor samples obtained from ESCC patients who underwent esophagectomy. Results ESCC cells strongly expressed CLIC1. The depletion of CLIC1 using siRNA inhibited cell proliferation, induced apoptosis, and promoted cell migration and invasion. The results of the microarray analysis revealed that the depletion of CLIC1 regulated apoptosis via the TLR2/JNK pathway. Immunohistochemistry showed that CLIC1 was present in the cytoplasm of carcinoma cells, and that the very strong or very weak expression of CLIC1 was an independent poor prognostic factor. Conclusion The present results suggest that the very strong expression of CLIC1 enhances tumor survival, while its very weak expression promotes cellular movement. The present study provides an insight into the role of CLIC1 as a switch among tumor behaviors in ESCC. Disclosure All authors have declared no conflicts of interest.

Molecular Pathogenesis of Sporadic Melanoma and Melanoma-Initiating Cells

2010 ◽  
Vol 134 (12) ◽  
pp. 1740-1749
Author(s):  
Yunyi Kong ◽  
Suresh M. Kumar ◽  
Xiaowei Xu
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cell Biology ◽  
Molecular Basis ◽  
Potential Role ◽  
Genetic Alterations ◽  
Stem Cell Biology ◽  
Prevalent Disease

Abstract Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of melanoma-initiating cells during melanomagenesis and progression will also be discussed. Understanding pathogenesis of melanoma may uncover new diagnostic clues and therapeutic targets for this increasingly prevalent disease.

Aberrant microRNA Expression in Radiation-Induced Rat Mammary Cancer: The Potential Role of miR-194 Overexpression in Cancer Cell Proliferation

2012 ◽  
Vol 179 (2) ◽  
pp. 151 ◽  
Author(s):  
Daisuke Iizuka ◽  
Tatsuhiko Imaoka ◽  
Mayumi Nishimura ◽  
Hidehiko Kawai ◽  
Fumio Suzuki ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Mammary Cancer ◽  
Potential Role ◽  
Microrna Expression ◽  
Cancer Cell Proliferation ◽  
Radiation Induced

Potential role of NF-kB in the negative regulation of human hepatic stellate cell proliferation

1998 ◽  
Vol 28 ◽  
pp. 83
Author(s):  
C. Gallois ◽  
A. Habib ◽  
T. Jiangchuang ◽  
J. Maclouf ◽  
A. Mallat ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Hepatic Stellate Cell ◽  
Potential Role ◽  
Stellate Cell ◽  
Negative Regulation ◽  
Human Hepatic Stellate Cell
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