scholarly journals Progressive Aortic Dilation Is Regulated by miR-17–Associated miRNAs

2016 ◽  
Vol 67 (25) ◽  
pp. 2965-2977 ◽  
Author(s):  
Jie Wu ◽  
Hui-Fang Song ◽  
Shu-Hong Li ◽  
Jian Guo ◽  
Katherine Tsang ◽  
...  
Keyword(s):  
Aortic Dilation ◽  
Progressive Aortic Dilation

Progressive aortic dilation and aortic stiffness in children with repaired tetralogy of Fallot

2013 ◽  
Vol 29 (1) ◽  
pp. 83-87 ◽  
Author(s):  
Mitsuru Seki ◽  
Clara Kurishima ◽  
Hirofumi Saiki ◽  
Satoshi Masutani ◽  
Hirokazu Arakawa ◽  
...  
Keyword(s):  
Tetralogy Of Fallot ◽  
Aortic Stiffness ◽  
Aortic Dilation ◽  
Repaired Tetralogy Of Fallot ◽  
Progressive Aortic Dilation

Sudden death 10 years after patch aortoplasty for coarctation

1998 ◽  
Vol 8 (3) ◽  
pp. 383-385 ◽  
Author(s):  
Michael Hauser ◽  
James pollock ◽  
Neil Wilson
Keyword(s):  
General Practitioner ◽  
Sudden Death ◽  
Aortic Coarctation ◽  
Surgical Intervention ◽  
Coarctation Of The Aorta ◽  
Aortic Dilation ◽  
Initial Operation ◽  
Dacron Patch ◽  
Progressive Aortic Dilation

AbstractA 25-year-old man died 10 years after a Dacron patch was used to repair a coarctation of the aorta. Death was due to rupture of an unrecognized aneurysm at the site of the patch. After the initial operation at the age of 15 years, there had been no signs of residual or recurrent obstruction. He had no evidence of hypertension and was discharged some years later from regular hospital follow-up to the care of his general practitioner. We strongly recommend that patients who have undergone repair of aortic coarctation by patch aortoplasty should have lifelong follow-up in cardiac units with imaging facilities for monitoring aortic dilation. We would now recommend surgical intervention in the presence of progressive aortic dilation.

Progressive Aortic Dilation Associated With ACTA2 Mutations Presenting in Infancy

PEDIATRICS ◽  
2015 ◽  
Vol 136 (1) ◽  
pp. e262-e266 ◽  
Author(s):  
A. T. Yetman ◽  
L. J. Starr ◽  
S. B. Bleyl ◽  
L. Meyers ◽  
J. W. Delaney
Keyword(s):  
Aortic Dilation ◽  
Progressive Aortic Dilation

Aortic disease and interventions in adults with tetralogy of Fallot

Heart ◽  
2018 ◽  
pp. heartjnl-2018-314115 ◽  
Author(s):  
Alexander C Egbe ◽  
William R Miranda ◽  
Naser M Ammash ◽  
Nandan S Anavekar ◽  
Venkata R Missula ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Aortic Aneurysm ◽  
Aortic Dissection ◽  
Aortic Valve Disease ◽  
Aortic Surgery ◽  
Leading Edge ◽  
Ascending Aorta ◽  
Valve Disease ◽  
Aortic Dilation ◽  
Progressive Aortic Dilation

BackgroundAortic dilation and aortic valve disease are known long-term complication of tetralogy of Fallot (TOF), but the risk of aortic dissection and the indications for prophylactic aortic surgery are unknown in this population. The purpose of this study was to: (1) determine the prevalence of significant aortic valve disease and/or significant aortic aneurysm (AVD-AA); (2) determine the incidence of progressive aortic dilation and aortic dissection in patients with TOF.MethodsRetrospective review of adults with repaired TOF, and no prior aortic valve/aorta surgery, who had ≥2 measurements of the thoracic aorta >12 months apart, 1990–2017. The aortic root and mid-ascending aorta were measured at the onset of QRS complex from leading edge to leading edge. Significant aortic valve disease was defined as the presence of ≥moderate aortic stenosis and/or ≥moderate aortic regurgitation. Significant aortic aneurysm was defined as aortic root or mid-ascending aorta dimension ≥50 mm. Progressive aortic dilation was defined as increase in aortic dimension ≥2 mm.ResultsOf the 453 consecutive patients (37±13 years, men 216 (49%)) in the study, aortic aneurysm was present in 312 (69%) based on normative data; progressive aortic dilation occurred in 40 (9%), and there was no case of aortic dissection. Significant AVD-AA occurred in 52 (12%) patients; and 15 of them (29%) underwent aortic surgery without any surgical mortality.ConclusionsAlthough aortic aneurysm was common, progressive aortic dilation was uncommon and aortic dissection did not occur in our patients with TOF with significant aortic aneurysms who did not undergo aortic surgery. This has important clinical implication in deciding the frequency of imaging follow-up and timing of surgical intervention in this population.

Clinical Outcome, Valve Dysfunction, and Progressive Aortic Dilation in a Pediatric Population With Isolated Bicuspid Aortic Valve

2013 ◽  
Vol 35 (5) ◽  
pp. 803-809 ◽  
Author(s):  
Gaia Spaziani ◽  
Piercarlo Ballo ◽  
Silvia Favilli ◽  
Veronica Fibbi ◽  
Lorenzo Buonincontri ◽  
...  
Keyword(s):  
Aortic Valve ◽  
Clinical Outcome ◽  
Bicuspid Aortic Valve ◽  
Pediatric Population ◽  
Aortic Dilation ◽  
Valve Dysfunction ◽  
Progressive Aortic Dilation

scholarly journals Self-navigated 3D whole-heart MRA for non-enhanced surveillance of thoracic aortic dilation: a comparison to CTA

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
P Poskaite ◽  
M Pamminger ◽  
C Kranewitter ◽  
C Kremser ◽  
M Reindl ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Image Quality ◽  
Aortic Aneurysm ◽  
Thoracic Aortic Aneurysm ◽  
Aortic Dilation ◽  
Subjective Image Quality ◽  
Contrast Enhanced ◽  
Whole Heart ◽  
Enhanced Computed Tomography ◽  
Contrast Enhanced Computed Tomography

Abstract Funding Acknowledgements Type of funding sources: None. Background The natural history of thoracic aortic aneurysm (TAA) is one of progressive expansion. Asymptomatic patients who do not meet criteria for repair require conservative management including ongoing aneurysm surveillance, mostly carried out by contrast-enhanced computed tomography angiography (CTA). Purpose To prospectively compare image quality and reliability of a prototype non-contrast, self-navigated 3D whole-heart magnetic resonance angiography (MRA) with contrast-enhanced computed tomography angiography (CTA) for sizing of thoracic aortic aneurysm (TAA). Methods Self-navigated 3D whole-heart 1.5 T MRA was performed in 20 patients (aged 67 ± 8.6 years, 75% male) for sizing of TAA; a subgroup of 18 (90%) patients underwent additional contrast-enhanced CTA on the same day. Subjective image quality was scored according to a 4-point Likert scale and ratings between observers were compared by Cohen’s Kappa statistics. Continuous MRA and CTA measurements were analyzed with regression and Bland-Altman analysis. Results Overall subjective image quality as rated by two observers was 1 [interquartile range (IQR) 1-2] for self-navigated MRA and 1.5 [IQR 1-2] for CTA (p = 0.717). For MRA a perfect inter-observer agreement was found for presence of artefacts and subjective image sharpness (κ=1). Subjective signal inhomogeneity correlated highly with objectively quantified inhomogeneity of the blood pool signal (r = 0.78-0.824, all p <0.0001). Maximum diameters of TAA as measured by self-navigated MRA and CTA showed excellent correlation (r = 0.997, p < 0.0001) without significant inter-method bias (bias -0.0278, lower and upper limit of agreement -0.74 and 0.68, p = 0.749). Inter- and intraobserver correlation of aortic aneurysm as measured by MRA was excellent (r = 0.963 and 0.967, respectively) without significant bias (all p ≤ 0.05). Conclusion Self-navigated 3D whole-heart MRA enables reliable contrast- and radiation free aortic dilation surveillance without significant difference to standardized CTA while providing predictable acquisition time and by offering excellent image quality. Abstract Figure.

High prevalence of ascending aortic dilation in adults with repaired coarctation of the aorta

2021 ◽  
pp. 1-6
Author(s):  
Daniel Rinnström ◽  
Mikael Dellborg ◽  
Ulf Thilén ◽  
Peder Sörensson ◽  
Niels-Erik Nielsen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Aortic Valve ◽  
Aortic Valve Disease ◽  
Congenital Heart ◽  
Coarctation Of The Aorta ◽  
Valve Disease ◽  
Aortic Dilation ◽  
Factors Associated ◽  
High Prevalence ◽  
Life Threatening

Abstract Background: Ascending aortic dilation is a feared complication in adults with repaired coarctation of the aorta, as the condition is associated with life-threatening complications such as aortic dissection and rupture. However, the data are currently limited regarding factors associated with ascending aortic dilation in these patients. Methods and results: From the national register of congenital heart disease, 165 adult patients (≥ 18 years old) with repaired coarctation of the aorta, and echocardiographic data on aortic dimensions, were identified (61.2% male, mean age 35.8 ± 14.5 years). Aortic dilation (aortic diameters > 2 SD above reference mean) was found in 55 (33.3%) of the 165 included patients, and was associated with manifest aortic valve disease in univariable logistic regression analysis (OR 2.44, 95% CI [1.23, 4.83]). Conclusions: Aortic dilation is common post-repair of coarctation of the aorta, and is associated with manifest aortic valve disease and thus indirectly with the presence of a bicuspid aortic valve. However, no association was found between aortic dilation and age or blood pressure.

Serial echocardiography for valve dysfunction and aortic dilation in bicuspid aortic valves

2021 ◽  
Vol 38 (3) ◽  
pp. 394-401
Author(s):  
Matthew W. Parker ◽  
Renee Dallasen Muchnik ◽  
Adedotun Ogunsua ◽  
Amartya Kundu ◽  
Suvasini Lakshmanan ◽  
...  
Keyword(s):  
Aortic Dilation ◽  
Aortic Valves ◽  
Valve Dysfunction ◽  
Bicuspid Aortic Valves

Association of Left Ventricular Hypertrophy and Aortic Dilation in Patients with Acute Thoracic Aortic Dissection

Angiology ◽  
2001 ◽  
Vol 52 (7) ◽  
pp. 447-455 ◽  
Author(s):  
Diana Iarussi ◽  
Aurelio Caruso ◽  
Maurizio Galderisi ◽  
Franco Enrico Covino ◽  
Giovanni Dialetto ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Aortic Dissection ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Aortic Dilation ◽  
Thoracic Aortic Dissection
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