scholarly journals GW26-e2370 Red Cell Distribution Width and Risk of Long-Term All-Cause Mortality and Cardiovascular Events Among Patients With Acute Coronary Syndrome: A Meta-Analysis of Observational Studies

2015 ◽  
Vol 66 (16) ◽  
pp. C2
Author(s):  
Yun Zhou ◽  
Dongze Li ◽  
Yining Yang ◽  
Yitong Ma
Keyword(s):  
Acute Coronary Syndrome ◽  
Cardiovascular Events ◽  
Observational Studies ◽  
Meta Analysis ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Coronary Syndrome ◽  
All Cause Mortality

scholarly journals Red Cell Distribution Width and Mortality in Patients With Acute Coronary Syndrome: A Meta-Analysis on Prognosis

2018 ◽  
Vol 9 (3) ◽  
pp. 144-152 ◽  
Author(s):  
Lauro L. Abrahan ◽  
John Daniel A. Ramos ◽  
Elleen L. Cunanan ◽  
Marc Denver A. Tiongson ◽  
Felix Eduardo R. Punzalan
Keyword(s):  
Acute Coronary Syndrome ◽  
Meta Analysis ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Coronary Syndrome

scholarly journals Clinical Outcomes of Concomitant Use of Proton Pump Inhibitors and Dual Antiplatelet Therapy: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Hongzhou Guo ◽  
Zhishuai Ye ◽  
Rongchong Huang
Keyword(s):  
Antiplatelet Therapy ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Cardiovascular Events ◽  
Observational Studies ◽  
Dual Antiplatelet Therapy ◽  
Meta Analysis ◽  
Gi Bleeding ◽  
Coronary Syndrome ◽  
All Cause Mortality

Background: The safety and efficacy associated with the use of proton pump inhibitors (PPIs) by patients with coronary artery disease receiving dual antiplatelet therapy (DAPT) remain unclear.Methods: The evaluated outcomes included combined major adverse cardiovascular events (MACEs), myocardial infarction (MI), all-cause mortality, and gastrointestinal (GI) bleeding. A random effects meta-analysis, stratified by study design, was performed and heterogeneity was assessed using the I2 statistic.Results: In total, 6 randomized controlled trials (RCTs) (6930 patients) and 16 observational studies (183,546 patients) were included. Analysis of RCTs showed that there were no significant differences in the incidences of MACEs (risk ratio [RR] = 0.89 [95% confidence interval (CI) = 0.75–1.05]), MI (RR = 0.93 [95% CI = 0.76–1.15]), and all-cause mortality (RR = 0.79 [95% CI = 0.50–1.23]) in the PPI groups vs. the non-PPI groups. Pooled data from observational studies revealed an inconsistent association between the use of each PPI subtype and the increased risks of MACEs during clopidogrel treatment. There was no increased risk of MACEs or all-cause mortality associated with the use of PPIs (as a class) and other P2Y12 inhibitors. Both the RCTs and observational studies revealed that the use of PPIs significantly reduced the risks of GI bleeding.Conclusion: The use of PPIs was associated with a reduced risk of GI bleeding in patients treated with DAPT after percutaneous coronary intervention or acute coronary syndrome. There was no clear evidence of an association between the use of PPIs and adverse cardiovascular events.Clinical Trial Registration: identifier [CRD42020190315]

scholarly journals Comparative Study between Red Cell Distribution Width and Creatine Kinase-MB as Prognostic Markers in Acute Coronary Syndrome

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
N M A Fahmy ◽  
A M S Boctor ◽  
D M Haiba ◽  
M A M Arfa
Keyword(s):  
Acute Coronary Syndrome ◽  
Comparative Study ◽  
Adverse Outcomes ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
University Hospitals ◽  
Distribution Width ◽  
Coronary Syndrome ◽  
Creatine Kinase Mb

Abstract Background over the last decade, cardiovascular disease (CVD) has become the single largest cause of death worldwide. Low and middle-income countries are seeing an alarming and accelerating increase in the rate of CVD and a higher mortality rate caused by coronary heart disease Aim of the Work is to evaluate the possible relationship between red cell distribution width and the adverse clinical outcomes (in hospital course) in patients with acute coronary syndrome. Patients and Methods it was a comparative study conducted in the department of ICU in Ain Shams University Hospitals, After approval by medical committee and informed consent, 60 patients (newly admitted to the ICU), with diagnosis of acute coronary syndrome defined by (the criteria of the American College of Cardiology/European Society of cardiology), The study was conducted in the period from June 2018 to July 2018, they were divided into two groups, Group A: 30 Patients have been monitored by CK-MB and, Group B: 30 Patients have been monitored by RDW and CK-MB, We aimed to determine whether RDW, measured on admission and at 6, 12, 24, 48 hours may predict the adverse outcomes of ACS during hospital admission. Results our study demonstrated that adverse events were more likely to occur in patients with ACS during short-term follow up if they had higher RDW values. Conclusion RDW is independent predictor for worse adverse outcomes in patients with acute coronary syndrome during hospital stay as RDW level was found to be higher in patients whom were heart failure, serious arrhythmia, mechanical complications, Re-infarction.

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