scholarly journals TCT-18 Long-term Outcome Of Discordance Between Fractional Flow Reserve And Coronary Flow Velocity Reserve After Deferral Of Percutaneous Coronary Intervention

2012 ◽  
Vol 60 (17) ◽  
pp. B5-B6
Author(s):  
Tim van de Hoef ◽  
Martijn Piek ◽  
M. Meuwissen ◽  
Ronak Delewi ◽  
Peter Damman ◽  
...  
Keyword(s):  
Coronary Flow ◽  
Coronary Intervention ◽  
Coronary Flow Velocity Reserve ◽  
Fractional Flow ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Coronary Flow Velocity ◽  
Flow Reserve ◽  
Percutaneous Coronary

Relationship between coronary flow velocity reserve and aortic stiffness

2006 ◽  
Vol 290 (3) ◽  
pp. H1311-H1311 ◽  
Author(s):  
A. Nemes ◽  
Tamás Forster ◽  
Miklós Csanády
Keyword(s):  
Flow Velocity ◽  
Coronary Flow ◽  
Aortic Stiffness ◽  
Coronary Intervention ◽  
Doppler Velocity ◽  
Coronary Perfusion ◽  
Coronary Flow Velocity Reserve ◽  
Fractional Flow ◽  
Coronary Flow Velocity ◽  
Flow Reserve

We examined the hypothesis that a stiff aorta is associated with reduced coronary blood flow (CBF) and CBF response to percutaneous coronary intervention (PCI). Aortic mechanical properties are thought to affect CBF, with increased stiffness associated with decreased coronary perfusion. Animal studies are conflicting, and human evidence is lacking. Even less is known about the effects of aortic stiffness on the CBF response to successful PCI. In 18 subjects undergoing elective PCI, a Doppler velocity guidewire was positioned proximal to a severe coronary stenosis to measure resting and adenosine-induced hyperemic CBF before and after PCI. Stenosis severity was assessed with Doppler velocity and pressure guidewires. Aortic mechanical indexes measured included central pulse-wave velocity (cPWV) and central pulse pressure (cPP). PCI was successful in all subjects (diameter stenosis: 88 ± 9% to 2 ± 7%; coronary flow velocity reserve: 1.8 ± 0.6 to 3.0 ± 0.8; fractional flow reserve: 0.57 ± 0.19 to 0.92 ± 0.06; all P < 0.001). With the adjustment for age and gender, resting and hyperemic CBF were inversely related to cPWV irrespective of the presence of stenosis (resting: before PCI, r2 = 0.452, P < 0.01; after PCI, r2 = 0.261, P = 0.043; hyperemic: before PCI r2 = 0.503, P = 0.005; after PCI r2 = 0.500, P = 0.002), whereas they were related to cPP in absence of stenosis (resting: r2 = 0.368, P = 0.022; hyperemic: r2 = 0.370, P = 0.016). Hyperemic CBF response ( P = 0.005) and hyperemic CBF improvement from PCI ( P = 0.025) were less marked in a stiff aorta than a compliant aorta. A stiff aorta is associated with a reduction in CBF, a lower hyperemic CBF response, and may reduce the improvement in hyperemic CBF after successful PCI.

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