scholarly journals Renal Sympathetic Denervation Reduces Left Ventricular Hypertrophy and Improves Cardiac Function in Patients With Resistant Hypertension

2012 ◽  
Vol 59 (10) ◽  
pp. 901-909 ◽  
Author(s):  
Mathias C. Brandt ◽  
Felix Mahfoud ◽  
Sara Reda ◽  
Stephan H. Schirmer ◽  
Erland Erdmann ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Cardiac Function ◽  
Resistant Hypertension ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Renal Sympathetic

Effects of renal sympathetic denervation in left ventricular hypertrophy in CKD refractory hypertensive patients

2016 ◽  
Vol 202 ◽  
pp. 121-123 ◽  
Author(s):  
Márcio Galindo Kiuchi ◽  
Miguel Luis Graciano ◽  
Maria Angela Magalhães de Queiroz Carreira ◽  
Tetsuaki Kiuchi ◽  
Shaojie Chen ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Left Ventricular ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Hypertensive Patients ◽  
Renal Sympathetic

scholarly journals Catheter-Based Radiofrequency Renal Sympathetic Denervation Decreases Left Ventricular Hypertrophy in Hypertensive Dogs

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Shan Tu ◽  
Zhi-Jie Shen ◽  
Xiao-Yan Wang ◽  
Li-Xiong Zeng ◽  
Zhi-Hui Zhang
Keyword(s):  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Left Ventricular Mass ◽  
Ventricular Hypertrophy ◽  
Sham Group ◽  
Left Ventricular ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Control Group ◽  
Renal Sympathetic

This study explored the effects of renal sympathetic denervation (RDN) on hyperlipidity-induced cardiac hypertrophy in beagle dogs. Sixty beagles were randomly assigned to the control group, RDN group, or sham-operated group. The control group was fed with a basal diet, while the other two groups were given a high-fat diet to induce model hypertension. The RDN group underwent an RDN procedure, and the sham-operated group underwent only renal arteriography. At 1, 3, and 6 months after the RDN procedure, the diastolic blood pressure (DBP) and systolic blood pressure (SBP) levels were markedly decreased in the RDN group relative to the sham group ( P < 0.05 ). After 6 months, serum norepinephrine (NE) and angiotensin II (AngII), as well as left ventricular levels, in the RDN group were statistically lower than those in the sham group ( P < 0.05 ). Also, the left ventricular mass (LVM) and left ventricular mass index (LVMI) were significantly decreased, while the E/A peak ratio was drastically elevated ( P < 0.05 ). Pathological examination showed that the degree of left ventricular hypertrophy and fibrosis in the RDN group was statistically decreased relative to those of the sham group and that the collagen volume fraction (CVF) and perivascular circumferential collagen area (PVCA) were also significantly reduced ( P < 0.05 ). Renal sympathetic denervation not only effectively reduced blood pressure levels in hypertensive dogs but also reduced left ventricular hypertrophy and myocardial fibrosis and improved left ventricular diastolic function. The underlying mechanisms may involve a reduction of NE and AngII levels in the circulation and myocardial tissues, which would lead to the delayed occurrence of left ventricular remodeling.

scholarly journals Effects of Renal Sympathetic Denervation in Diastolic Heart Function in CKD Refractory Hypertensive Patients

2016 ◽  
Vol 1 ◽  
Author(s):  
Márcio Galindo Kiuchi ◽  
Miguel Luis Graciano ◽  
Maria Angela Magalhães de Queiroz Carrei ◽  
Tetsuaki Kiuchi ◽  
Jocemir Ronaldo Lugon
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Heart Function ◽  
Diastolic Heart Failure ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Early Assessment ◽  
Renal Sympathetic

<p>Diastolic heart failure (HF) is an important factor that increases mortality related to the cardiovascular system in patients with chronic kidney disease (CKD) whose extent of kidney function deterioration differs. As a non-invasive method to allow early assessment, the E/e’ ratio estimated by tissue Doppler imaging can predict mortality and cardiovascular events in CKD patients with diastolic dysfunction. The current study evaluated 15 patients with CKD and left ventricular hypertrophy (LVH), who were selected according to a previously published protocol. In the present study, we reported for the first time the improvement in diastolic parameters measured by echocardiography in CKD patients with resistant hypertension and left ventricular hypertrophy 6 months after renal sympathetic denervation (RSD). Our results suggest that RSD in this kind of patients seems to avoid the progression to diastolic HF.</p>

Abstract 15206: Sustained Beneficial Effects of Multi-Electrode Renal Sympathetic Denervation on Cardiac Adaptations in Resistant Hypertension: A 24-months Follow-Up Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Kyriakos Dimitriadis ◽  
Costas Tsioufis ◽  
Alexandros Kasiakogias ◽  
Panayiotis Vasileiou ◽  
Aggelos Papanikolaou ◽  
...  
Keyword(s):  
Diastolic Function ◽  
Resistant Hypertension ◽  
Interventricular Septum ◽  
Left Ventricular ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Number Of Patients ◽  
Lv Mass ◽  
Renal Sympathetic

Introduction: The favorable impact of renal sympathetic denervation (RDN) on cardiac parameters such as on left ventricular (LV) morphology, geometry and function has been shown up to 6 months after the procedure using diverse ablation systems. Hypothesis: Multi-electrode catheter-based renal sympathetic RDN may have favorable effects on LV structural and functional indices in patients with resistant hypertension after a follow-up of 24 months. Methods: Twenty patients with resistant hypertension [age: 57±10 years, 13 males, office blood pressure (BP): 182/97±19/18 mmHg under 4.5±0.6 drugs] who underwent RDN were followed-up for 24 months. A full transthoracic echocardiographic study was performed in all patients and LV mass was calculated using the Devereux formula and was indexed for body surface area and height. Results: Average office BP was reduced to 148±21/85±14 mmHg at 12 months and to 143±23/80±14 mmHg at 24 months (p<0.001 for all). In the RDN group, LV mass index was significantly reduced from 136±20.1 g/m 2 (56.5±8.7 g/m 2.7 ) to 121±16.6 g/m 2 (50.6±6 g/m 2.7 ) at 12 months and to 115.6±23.3 g/m 2 (48.8±9.3 g/m 2.7 ) at 24 months (p<0.01 for all). RDN decreased mean interventricular septum thickness from 12.1±1.2 mm to 11.4±0.9 mm at 12 months and to 11.3±0.9 mm at 24 months (p<0.05 for all). After RDN, the number of patients with concentric LV hypertrophy (i.e. relative wall thickness >0.42 and LV mass >48 g/m 2.7 for male and >44 g/m 2.7 for female) decreased from 16 patients (80%) at baseline to 10 patients (50%) at 12 months, and to 7 patients (36.8%) at 24 months. Regarding diastolic function RDN caused an increase in mitral valve E'/A' ratio from 0.62±0.28 to 0.70±0.25 at 12 months and to 0.84±0.32 at 24 months (p<0.05 for all) and a decrease in the E/E' ratio from 14.8±6.1 to 11.8±3.7 at 12 months and to 9.7±4 at 24 months (p<0.05 for all). Conclusions: This the first study to show that multi-electrode RDN results in a significant and sustained improvement of diastolic function and attenuation of LV mass index in increased cardiovascular risk resistant hypertensive patients after a follow-up of 24 months. These results suggest long-term pleiotropic cardiovascular benefits of RDN therapy in the setting of resistant hypertension.

scholarly journals sST2 Predicts Short Term Therapy Success in Patients with Therapy Resistant Hypertension after Renal Sympathetic Denervation

2021 ◽  
Vol 11 (23) ◽  
pp. 11130
Author(s):  
Albert Topf ◽  
Vera Paar ◽  
Janine Grueninger ◽  
Bernhard Wernly ◽  
Kristen Kopp ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Early Intervention ◽  
Resistant Hypertension ◽  
Serum Levels ◽  
Clinical Parameter ◽  
Left Ventricular ◽  
Sympathetic Denervation ◽  
Renal Sympathetic Denervation ◽  
Term Therapy ◽  
Renal Sympathetic

Background: Renal sympathetic denervation (RSD) has provided promising data in its ability to treat therapy resistant arterial hypertension. The effect of RSD on sST-2, a promising biomarker for risk stratification in cardiovascular diseases, has so far not been systematically studied. Methods: We evaluated serum levels of sST-2 and clinical parameter including left ventricular mass (LVM) in 54 patients with resistant hypertension (RH) undergoing bilateral RSD at baseline as well as at one and/or three months. Results: After RSD, mean office blood pressure showed a significant decrease after one month (p < 0.001). On echocardiography a reduction of LVM was observed at three months (p < 0.01). This was accompanied by a significant decrease of sST-2 levels at three months (sST-2 baseline: 6310.1 ± 3246.0 pg/mL vs. sST-2 three months: 4703.8 ± 1585.9 pg/mL, p = 0.048). Furthermore, baseline sST-2 levels were positively correlated with systolic blood pressure at one month (r = 0.514, p < 0.01) but not three months, indicating a potential predictive value of sST-2 for early intervention success. Conclusion: In patients with RH, RSD is associated with a significant decrease of sST-2 levels after three months, indicating sST-2 to be involved in remodeling processes after RSD. Furthermore, lower sST-2 levels at baseline might be a potential predictor of early intervention success of RSD.

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