Autoimmune diseases of the innate and adaptive immune system including atopic dermatitis, psoriasis, and tertiary treponematosis

2016 ◽  
Vol 74 (5) ◽  
pp. AB143
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Autoimmune Diseases ◽  
Adaptive Immune System ◽  
Adaptive Immune

scholarly journals Primer immunhiány és autoimmun betegségek

2018 ◽  
Vol 159 (23) ◽  
pp. 908-918
Author(s):  
Györgyi Műzes ◽  
Ferenc Sipos
Keyword(s):  
Immune System ◽  
Autoimmune Diseases ◽  
Primary Immunodeficiency ◽  
Adaptive Immune System ◽  
Infectious Complications ◽  
Primary Immunodeficiencies ◽  
Cellular Mechanisms ◽  
Adaptive Immune ◽  
Solid Malignancies ◽  
Autoimmune Phenomena

Abstract: Primary immunodeficiencies consist of a group of genetically heterogeneous immune disorders affecting distinct elements of the innate and adaptive immune system. Patients with primary immunodeficiency are more prone to develop not only recurrent infections, but non-infectious complications, like inflammatory or granulomatous conditions, lymphoproliferative and solid malignancies, autoinflammatory disorders, and a broad spectrum of autoimmune diseases. The concomitant appearance of primary immunodeficiency and autoimmunity appears to be rather paradoxical, therefore making the diagnosis of immunodeficiency patients with autoimmune complications challenging. Mutations of one or more genes playing a fundamental role in immunoregulation and/or immune tolerance network are thought to be responsible for primary immunodeficiencies. The diverse immunological abnomalities along with the compensatory and excessive sustained inflammatory response result in tissue damage and finally in manifestation of organ-, cell-specific or systemic autoimmune diseases. Several forms of primary immunodeficiency disorders are characterized by a variety of specific autoimmune phenomena. This overview addresses the spectrum of autoimmune diseases associated with primary immunodeficiencies, and explores the molecular and cellular mechanisms underlying abnormalities of the immune system. The case presented finally highlights that both the recognition of autoimmune diseases in association with immunodeficiencies and the diagnosis of immunodefiency in those phenotypes with predominant autoimmunity could be challenging. Orv Hetil. 2018; 159(23): 908–918.

The adaptive immune system in atopic dermatitis and implications on therapy

2016 ◽  
Vol 12 (7) ◽  
pp. 787-796 ◽  
Author(s):  
Lennart M. Roesner ◽  
Thomas Werfel ◽  
Annice Heratizadeh
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Adaptive Immune System ◽  
Adaptive Immune

Are autoimmune diseases autoinflammatory: Is it time to change the paradigm?

Lupus ◽  
2021 ◽  
pp. 096120332110389
Author(s):  
Daniel Albert
Keyword(s):  
Immune System ◽  
Autoimmune Diseases ◽  
Innate Immune System ◽  
Adaptive Immune System ◽  
Innate Immune ◽  
Research Focus ◽  
Adaptive Immune

The paradigm that autoimmune diseases are abberations in the adaptive immune system is over 50 years old, but recent data suggest a multitude of abnormalities in the innate immune system in lupus and other autoimmune diseases. This viewpoint elaborates the reasons that I think it is time to reexamine this paradigm and shift our research focus to the innate immune system in lupus and other prototypic autoimmune diseases.

scholarly journals Immune Alterations in IgE and Non IgE-Associated Atopic Dermatitis

2014 ◽  
Vol 8 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Giampaolo Ricci ◽  
Elisabetta Calamelli ◽  
Francesca Cipriani
Keyword(s):  
Atopic Dermatitis ◽  
Immune System ◽  
Complex Disease ◽  
Adaptive Immune Response ◽  
Adaptive Immune System ◽  
Skin Barrier ◽  
Underlying Mechanism ◽  
Adaptive Immune ◽  
New Findings ◽  
Immune Alterations

Atopic dermatitis is a complex disease in which a strong interaction between alterations of skin barrier and the adaptive immune system coexists. In the recent years, new findings have underlined the importance of skin proteins, especially filaggrin, which participate to the outmost layers of the skin. To strengthen this physical barrier, many factors are available, such as antimicrobial peptides, chemokines and cytokines produced by keratinocytes. Skin disruption can easily allow the allergen penetration and the local keratinocytes can promote the adaptive immune response toward a Th2 phenotype. On the other side, allergic Th2 cytokines may downregulate the production of skin barrier proteins, facilitating the penetration of allergens. Moreover, data on murine models show the absolute relevance of the systemic immune system to develop clinical skin reaction. Since the clinical aspect of patients with AD does not show different patterns whatever is the prevalent underlying mechanism, in clinical practice it is difficult to translate the different endotypes beside the IgE and non IgE associated forms. The aim of this review is to point out to the most recent knowledge in this field, which makes AD more difficult to frame in a unique clinical entity.

Evolution and age characteristics of the innate and adaptive immune system

2016 ◽  
Vol 75 (3) ◽  
pp. 74-84 ◽  
Author(s):  
A.E. Abaturov ◽  
◽  
E.A. Agafonova ◽  
N.I. Abaturova ◽  
V.L. Babich ◽  
...  
Keyword(s):  
Immune System ◽  
Adaptive Immune System ◽  
Adaptive Immune
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