Fractional ablative laser followed by transdermal acoustic wave to enhance the drug delivery of aminolevulinic acid

2015 ◽  
Vol 72 (5) ◽  
pp. AB268 ◽  
Keyword(s):  
Drug Delivery ◽  
Acoustic Wave ◽  
Aminolevulinic Acid ◽  
Ablative Laser ◽  
Fractional Ablative Laser

scholarly journals In Vivo Histopathologic Comparison of the Acute Injury Following Treatment With Five Fractional Ablative Laser Devices

2010 ◽  
Vol 30 (3) ◽  
pp. 457-464 ◽  
Author(s):  
J. P. Farkas ◽  
J. A. Richardson ◽  
C. F. Burrus ◽  
J. E. Hoopman ◽  
S. A. Brown ◽  
...  
Keyword(s):  
Acute Injury ◽  
Laser Devices ◽  
Ablative Laser ◽  
Fractional Ablative Laser

scholarly journals The use of CO2 ablative fractional laser, non-ablative picosecond fractional lasers 1064 nm and 755 nm and needle mesotherapy in combined therapy to reduce stretch marks and skin laxity. A clinical case

2021 ◽  
Vol 10 (5) ◽  
pp. 253-259
Author(s):  
Agnieszka Surgiel-Gemza ◽  
◽  
Krzysztof Gemza ◽  
◽  
◽  
...  
Keyword(s):  
Clinical Case ◽  
Combined Therapy ◽  
Surgical Results ◽  
Alexandrite Laser ◽  
Fractional Laser ◽  
Aesthetic Medicine ◽  
Skin Laxity ◽  
Stretch Marks ◽  
Ablative Laser ◽  
Fractional Ablative Laser

Stretch marks are a common problem and a challenge for cosmetologists and aesthetic medicine doctors. Due to the complex etiopathogenesis and difficulties in their reduction, specialists use various therapeutic methods. In this study, the described case confirms the effectiveness of selected combined therapy in reducing stretch marks and skin laxity. Impressive surgical results were obtained with the implementation of combined therapy consisting of the use of non-ablative Nd:YAG fractional laser and alexandrite laser in picosecond technology, CO2 fractional ablative laser and needle mesotherapy treatments.

Research Perspectives on Functional Micro and Nano Scale Coatings

2020 ◽  
pp. 1076-1109
Author(s):  
Jaime Andrés Pérez Taborda ◽  
Elvis O. López
Keyword(s):  
Drug Delivery ◽  
Acoustic Wave ◽  
Aluminum Nitride ◽  
Dielectric Material ◽  
Tooth Enamel ◽  
Wide Band ◽  
Medical Applications ◽  
Wide Band Gap ◽  
Research Perspectives ◽  
Acoustic Wave Sensor

Research topics related to the production of nanocomposites are the most important directions of development of new semiconductor engineering, ensuring high nanocomposites obtaining useful properties in the scope of biophysical characteristics, biomedical and piezoelectric applications. We present two case studies as Hydroxyapatite are in medical applications and aluminum nitride as acoustic wave sensor. Hydroxyapatite, is the main inorganic structure of the tooth enamel and bone and is a biomaterial that is commonly used in biomedical applications that involve bone substitution, drug delivery and bone regeneration because of its excellent biocompatibility, high bioactivity and good osseoconductivity. Since the past decade. Aluminum nitride (AlN), an electrical insulating ceramic with a wide band gap of 6.3 eV, is a potentially useful dielectric material very important in fields such as optoelectronic and micro electronics.

scholarly journals Inhaled Pulmonary Drug Delivery Platform Using Surface Acoustic Wave Atomization

2009 ◽  
Author(s):  
Aisha Qi ◽  
James R. Friend ◽  
Leslie Y. Yeo
Keyword(s):  
Drug Delivery ◽  
Lithium Niobate ◽  
Acoustic Wave ◽  
Size Distribution ◽  
Surface Acoustic Wave ◽  
Systemic Exposure ◽  
Pulmonary Drug Delivery ◽  
Lung Model ◽  
Working Fluid ◽  
Lung Area

Atomization has been widely applied in pulmonary drug delivery as a promising technology to transport drug formulations directly to the respiratory tract in the form of inhaled particles or droplets. Because of the targeted treatment, the drug can be delivered directly to the site of inflammation, thus the need for systemic exposure and the possibility of side effects are both reduced. Therefore pulmonary drug delivery has significant advantages over other methods in the treatment of respiratory diseases such as asthma. The most common atomization methods employed in pulmonary drug delivery are jet atomization and ultrasonic atomization. However, the difficulty is in producing monodispersed particles/droplets in a size range of 1–5 micron meter in diameter, necessary for deposition in the targeted lung area or lower respiratory airways, within a controllable fashion. In this paper, we demonstrate surface acoustic wave (SAW) atomization as an efficient technique to generate monodispersed aerosol to produce the required size distribution. The SAW atomizer is made of a 127.86 Y-X rotated single-crystal lithium niobate piezoelectric substrate, which is patterned with chromium-aluminum interdigital transducer (IDT) electrodes via UV lithography. When an alternating electric field is applied onto lithium niobate substrate through the IDT, a SAW, propagating across substrate surface with ten nanometer order amplitudes, is generated. When the SAW meets the liquid which is placed upon substrate, the acoustic energy carried by the wave induces atomization of the working fluid, which contains salbutamol as a model drug. In order to measure the size distribution of the atomized droplets, two methods are used. One is the laser diffraction based Spraytec technique and the other is an in-vitro lung modelthe one stage glass twin impinger. The former revealed that the mean diameter of the aerosol atomized was around 3 um which were confirmed by the lung model that demonstrated that nearly 80% of atomized drug aerosol was deposited in the simulated lung area. Moreover, the SAW atomizer only requires 1–3 W driving power, suggesting that it can be miniaturized for portable consumer use.

5-Aminolevulinic acid functionalized boron-nitride and carbon nanotubes as drug delivery vehicles for skin anticancer drugs: a theoretical study

RSC Advances ◽  
2016 ◽  
Vol 6 (95) ◽  
pp. 92547-92559 ◽  
Author(s):  
Pabitra Narayan Samanta ◽  
Kalyan Kumar Das
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Boron Nitride ◽  
Theoretical Study ◽  
Aminolevulinic Acid ◽  
Quantum Chemical Study ◽  
Chemical Study ◽  
Drug Molecule ◽  
Drug Delivery Vehicles ◽  
Delivery Vehicles

A quantum chemical study has been made on the interaction of 5-aminolevulinic acid (ALA) drug molecule with boron-nitride and carbon nanotubes so as to use these nanomaterials as drug-delivery vehicles.

112 Improvements in Burn Hypertrophic Scar After Fractional Ablative Laser Scar Revision

2020 ◽  
Vol 41 (Supplement_1) ◽  
pp. S74-S75
Author(s):  
Taryn E Travis ◽  
Rebekah R Allely ◽  
Laura S Johnson ◽  
Jeffrey W Shupp
Keyword(s):  
Laser Therapy ◽  
Hypertrophic Scar ◽  
Post Injury ◽  
Scar Revision ◽  
Scar Assessment ◽  
Time Period ◽  
Wide Range ◽  
Baseline Evaluation ◽  
Ablative Laser ◽  
Fractional Ablative Laser

Abstract Introduction Fractional ablative laser therapy use is increasing for treating burn hypertrophic scar (HTS). However, standard components of a routine HTS evaluation prior to starting laser scar revision (LSR) and after each intervention have yet to be determined, and metrics for effective treatment have not been established. Methods Patients who entered a LSR program between September 2018 and September 2019, underwent at least two LSR treatments, and completed post-LSR scar evaluations for each of these treatments were included in the studied sample. Patients were treated with a fractional ablative CO2 laser. A single burn rehabilitation therapist conducted all pre- and post-procedure scar evaluations, which included the Patient and Observer Scar Assessment Scale (POSAS), Vancouver Scar Scale (VSS), Institutional Scar Comparison Scale (SCS), durometry, and active range of motion (AROM) measurements. Results From 9/2018 to 9/2019, 25 patients began the LSR program and underwent at least two treatments with post-laser scar assessments for each intervention. Patients underwent an average of 3±1 LSR sessions during the time period for a total of 84 sessions amongst the group. Patients averaged 51±14 years old (range 26–80), with all Fitzpatrick skin types represented (mode type 5). Average HTS age was 14±19 months post-injury (range 3–98 months post injury). After one session of LSR, 91% of patients improved in at least one scar assessment metric (average 3±1.4 areas). After two sessions, all patients showed improvement in at least one metric (average 3.6±1.2 areas). One LSR session was associated with a 10.8±31.9% improvement in AROM of a HTS-affected joint, and this increased to 38.1±41.4% after five LSR treatments (p=0.0002). Durometry readings demonstrated decreasing scar hardness compared to adjacent uninjured skin in 90% of patients, and 96% of patients experienced improvements in POSAS, VSS, and SCS scores during a treatment course. Conclusions Improvements in burn HTS can be achieved with fractional ablative laser therapy in a wide range of scar ages and skin types, as early as the first LSR session. These continue to increase as additional sessions are performed. Applicability of Research to Practice This work suggests necessary baseline evaluation components for patients undergoing LSR, as well as a timeline for expected clinical improvements. This data may inform conversations with burn survivors and providers when considering laser therapy for symptomatic HTS.

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