Predictive value of margins in diagnostic biopsies of nonmelanoma skin cancers

Background: Systemic photoprotection (i.e., administration of substances such as nicotinamide, carotenoids, and vitamin D) may be important to reduce photocarcinogenesis or to support long-term protection against UV irradiation. Clinical trials showed that oral nicotinamide is effective in reducing the onset of new nonmelanoma skin cancers (NMSCs), while other oral photoprotectors failed to achieve the reduction of new melanoma or NMSC formation in humans. The aim of this study was to summarize the current state of knowledge of systemic photoprotection and to evaluate the knowledge and attitude of dermatologists regarding these treatments. Methods: The survey was conducted on a sample of dermatologists recruited according to a snowball sampling procedure. The questionnaire consisted of a first part asking for characteristics of the participant and a second part with 12 specific questions on their knowledge about systemic photoprotection, particularly their knowledge of astaxanthin, β-carotene, nicotinamide, and vitamin D3. Results: One hundred eight dermatologists answered the survey. Most of them (85.2%) stated that oral photoprotectors have a role in the prevention of skin cancer, and responses mainly mentioned nicotinamide. More than half of them (54.6%) had prescribed all the considered oral photoprotectors, but the majority of them had prescribed nicotinamide, mainly for 2 to 3 months during summer, almost invariably (n = 106) associated with topical photoprotectors. Most dermatologists (>80%) were aware of scientific publications demonstrating an effect of systemic photoprotectors on NMSC. Conclusions: Most Italian dermatologists have positive views on oral photoprotection in skin cancer and are aware of the demonstrated potential of nicotinamide in the prevention of NMSCs.

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Genetic parkinsonisms and cancer: a systematic review and meta-analysis

Reviews in the Neurosciences ◽

10.1515/revneuro-2020-0083 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Andrea Sturchio ◽

Alok K. Dwivedi ◽

Joaquin A. Vizcarra ◽

Martina Chirra ◽

Elizabeth G. Keeling ◽

...

Keyword(s):

Head And Neck ◽

Meta Analysis ◽

Head And Neck Cancers ◽

Breast Cancers ◽

Asymptomatic Carriers ◽

Skin Cancers ◽

Prostate Cancers ◽

Meta Analyses ◽

Genetic Contributions ◽

Nonmelanoma Skin Cancers

AbstractGenes associated with parkinsonism may also be implicated in carcinogenesis, but their interplay remains unclear. We systematically reviewed studies (PubMed 1967–2019) reporting gene variants associated with both parkinsonism and cancer. Somatic variants were examined in cancer samples, whereas germline variants were examined in cancer patients with both symptomatic and asymptomatic (carriers) genetic parkinsonisms. Pooled proportions were calculated with random-effects meta-analyses. Out of 9,967 eligible articles, 60 were included. Of the 28 genetic variants associated with parkinsonism, six were also associated with cancer. In cancer samples, SNCA was predominantly associated with gastrointestinal cancers, UCHL1 with breast cancer, and PRKN with head-and-neck cancers. In asymptomatic carriers, LRRK2 was predominantly associated with gastrointestinal and prostate cancers, PRKN with prostate and genitourinary tract cancers, GBA with sarcoma, and 22q11.2 deletion with leukemia. In symptomatic genetic parkinsonism, LRRK2 was associated with nonmelanoma skin cancers and breast cancers, and PRKN with head-and-neck cancers. Cancer was more often manifested in genetic parkinsonisms compared to asymptomatic carriers. These results suggest that intraindividual genetic contributions may modify the co-occurrence of cancer and neurodegeneration.

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Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients

BioMed Research International ◽

10.1155/2013/349526 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Christina Wlodek ◽

Faisal R. Ali ◽

John T. Lear

Keyword(s):

Photodynamic Therapy ◽

Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Actinic Keratoses ◽

Organ Transplant Recipients ◽

Skin Cancers ◽

Effective Treatment Modality ◽

Nonmelanoma Skin Cancers

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.

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Nonmelanoma skin cancers in people of color

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2017.04.703 ◽

2017 ◽

Vol 76 (6) ◽

pp. AB181

Keyword(s):

People Of Color ◽

Skin Cancers ◽

Nonmelanoma Skin Cancers

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Human Papillomavirus Infections in Nonmelanoma Skin Cancers From Renal Transplant Recipients and Nonimmunosuppressed Patients

JNCI Journal of the National Cancer Institute ◽

10.1093/jnci/88.12.802 ◽

1996 ◽

Vol 88 (12) ◽

pp. 802-811 ◽

Cited By ~ 212

Author(s):

V. Shamanin ◽

H. z. Hausen ◽

D. Lavergne ◽

C. M. Proby ◽

I. M. Leigh ◽

...

Keyword(s):

Human Papillomavirus ◽

Renal Transplant ◽

Renal Transplant Recipients ◽

Transplant Recipients ◽

Papillomavirus Infections ◽

Skin Cancers ◽

Nonmelanoma Skin Cancers

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A Comparative Study Between Smartphone-Based Microscopy and Conventional Light Microscopy in 1021 Dermatopathology Specimens

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2014-0593-oa ◽

2016 ◽

Vol 140 (1) ◽

pp. 86-90 ◽

Cited By ~ 13

Author(s):

Richard R. Jahan-Tigh ◽

Garrett M. Chinn ◽

Ronald P. Rapini

Keyword(s):

Light Microscopy ◽

Cell Carcinoma ◽

Sensitivity And Specificity ◽

Performance Characteristics ◽

University Hospital ◽

Inflammatory Conditions ◽

Skin Cancers ◽

And Performance ◽

Nonmelanoma Skin Cancers ◽

Conventional Light Microscopy

Context The incorporation of high-resolution cameras into smartphones has allowed for a variety of medical applications including the use of lens attachments that provide telescopic, macroscopic, and dermatoscopic data, but the feasibility and performance characteristics of such a platform for use in dermatopathology have not been described. Objective To determine the diagnostic performance of a smartphone microscope compared to traditional light microscopy in dermatopathology specimens. Design A simple smartphone microscope constructed with a 3-mm ball lens was used to prospectively evaluate 1021 consecutive dermatopathology cases in a blinded fashion. Referred, consecutive specimens from the community were evaluated at a single university hospital. The performance characteristics of the smartphone platform were calculated by using conventional light microscopy as the gold standard. The sensitivity and specificity for the diagnosis of melanoma, nonmelanoma skin cancers, and other miscellaneous conditions by the phone microscopy platform, as compared with traditional light microscopy, were calculated. Results For basal cell carcinoma (n = 136), the sensitivity and specificity of smartphone microscopy were 95.6% and 98.1%, respectively. The sensitivity and specificity for squamous cell carcinoma (n = 94) were 89.4% and 97.3%, respectively. The lowest sensitivity was found in melanoma (n = 15) at 60%, although the specificity was high at 99.1%. The accuracy of diagnosis of inflammatory conditions and other neoplasms was variable. Conclusions Mobile phone–based microscopy has excellent performance characteristics for the inexpensive diagnosis of nonmelanoma skin cancers in a setting where a traditional microscope is not available.

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