scholarly journals Transdermal delivery of clostridium botulinum toxin type A by pulsed current iontophoresis

2007 ◽  
Vol 56 (2) ◽  
pp. AB85
Keyword(s):  
Botulinum Toxin ◽  
Transdermal Delivery ◽  
Clostridium Botulinum ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Pulsed Current

STUDIES ON THE ORAL TOXICITY OF CLOSTRIDIUM BOTULINUM TOXIN, TYPE A

1954 ◽  
Vol 32 (1) ◽  
pp. 27-34 ◽  
Author(s):  
Ivan W. Coleman
Keyword(s):  
Botulinum Toxin ◽  
Clostridium Botulinum ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Blood Stream ◽  
Oral Toxicity ◽  
Crude Preparation ◽  
Spray Dried

Three aspects of the reported oral toxicity of Clostridium botulinum toxin, Type A, were investigated. No demonstrable migration of the crystalline toxin from the lumen of the intestine into the blood stream of the dog could be found. Evidence indicating that the crystalline toxin was inactivated by pepsin and chymotrypsin was obtained, but the toxin was found to be resistant to the action of trypsin. Comparison of the oral toxicity and the intraperitoneal toxicity of the crystalline toxin revealed that the product was not orally toxic. A spray-dried crude preparation of the toxin demonstrated a low oral toxicity.

Studies using Clostridium botulinum toxin—Type A

1965 ◽  
Vol 7 (1) ◽  
pp. 84-89 ◽  
Author(s):  
L.G. Hart ◽  
R.L. Dixon ◽  
J.P. Long ◽  
B. Mackay
Keyword(s):  
Botulinum Toxin ◽  
Clostridium Botulinum ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type

Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A

2002 ◽  
Vol 25 (2) ◽  
pp. 219-228 ◽  
Author(s):  
John A. Chaddock ◽  
Michael H. Herbert ◽  
Roger J. Ling ◽  
Frances C.G. Alexander ◽  
Sarah J. Fooks ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Clostridium Botulinum ◽  
Botulinum Toxin Type A ◽  
Type A ◽  
Botulinum Toxin Type ◽  
Expression And Purification ◽  
Catalytically Active ◽  
Derivatives Of
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