Imiquimod 5% cream in the treatment of Bowen's disease and invasive squamous cell carcinoma

2006 ◽  
Vol 55 (2) ◽  
pp. 324-327 ◽  
Author(s):  
Ketty Peris ◽  
Tamara Micantonio ◽  
Maria Concetta Fargnoli ◽  
Gian Piero Lozzi ◽  
Sergio Chimenti
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Invasive Squamous Cell Carcinoma ◽  
Bowen’S Disease ◽  
Bowen's Disease

scholarly journals Cutaneous Bowen’s Disease: an Analysis of 182 Cases according To Age, Sex, and Anatomical Site from an Italian Center

2019 ◽  
Vol 7 (4) ◽  
pp. 696-697
Author(s):  
Massimiliano Scalvenzi ◽  
Alessia Villani ◽  
Caterina Mazzella ◽  
Gabriella Fabbrocini ◽  
Claudia Costa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Anatomical Site ◽  
Invasive Squamous Cell Carcinoma ◽  
Bowen’S Disease ◽  
Bowen's Disease ◽  
Exposed Region ◽  
Male Patients

Bowen's disease (BD), also known as squamous cell carcinoma in situ, is a type of non-melanocytic intraepidermal malignancy characterised by a slowly enlarging erythematous to pink, scaly patch or plaque with irregular and well-demarcated borders. These lesions are usually persistent and progressive; it has been estimated that in general population around 3% to 5% of Bowen's disease transform into invasive squamous cell carcinoma. This report describes our experience with cutaneous BD and assesses the differences found about age, sex and anatomical site. Bowen’s disease was seen more frequently in male patients rather than in female patients in contrast to what confirmed in literature - this difference is probably because being head-neck an exposed region, patients are more easily induced to autoexam and to consult the dermatologist.

Multicentric Squamous Cell Carcinoma in situ Resembling Bowen's Disease in Cats

1993 ◽  
Vol 30 (6) ◽  
pp. 535-543 ◽  
Author(s):  
K. E. Baer ◽  
K. Helton
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma In Situ ◽  
Invasive Squamous Cell Carcinoma ◽  
Human Beings ◽  
Bowen’S Disease ◽  
Bowen's Disease

Multicentric squamous cell carcinoma in situ was studied in 12 cats (eight castrated males and four spayed females). The neoplasms occurred in middle-aged to old (mean age = 12 years) mixed-breed cats with a variety of hair-coat colors. The lesions were found in haired pigmented regions of the skin, including the trunk, limbs, feet, head, and neck, and were unrelated to exposure to sunlight. Lesions occurred at multiple sites in nine cats and at solitary sites in three cats and were from 0.5 cm to 3.0 cm in diameter, irregular, slightly, elevated, plaque-like or papillated, and partially alopecic. Histologically, the lesions consisted of sharply demarcated regions of necoplastic, keratinocytic infiltration of the epidermal and follicular infundibular epithelium. Neoplastic cells were confined to the epithelium without frank invasion of the dermis. Two histologic subclasses of multicentric squamous cell carcinoma in situ were identified, the irregular nonhyperkeratotic type and the verrucous hyperkeratotic type. Three cats also had invasive squamous cell carcinoma adjacent to lesions characteristic of multicentric squamous cell carcinoma in situ. Grossly, these were solitary 2.0–4.0 cm-diameter firm, crusted, crateriform cutancous masses. During follow-up periods of 4 to 20 months (mean follow-up period = 11 months), neoplasms did not recur locally after surgical excision; however, similar lesions developed at new sites in four cats. None of the cats had evidence of metastases. Multicentric squamous cell carcinoma in situ in cats is a biologically premalignant neoplasm histologically similar to Bowen's disease in human beings.

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