Interest of a new salicylic acid derivative in the prevention of acne relapses

2004 ◽  
Vol 50 (3) ◽  
pp. P19
Author(s):  
André M Rougier ◽  
Brigitte Dreno ◽  
Anne Khammari ◽  
Alain Richard
Keyword(s):  
Salicylic Acid ◽  
Acid Derivative

Hypouricemic effect of MK 647, a new salicylic acid derivative, in normal human

Abstracts ◽  
1977 ◽  
pp. 258
Author(s):  
Albert Dresse ◽  
Paul Fischer ◽  
Marie-Anne Gérard ◽  
Léo Verhaest ◽  
Ken Tempero
Keyword(s):  
Salicylic Acid ◽  
Acid Derivative ◽  
Normal Human

scholarly journals SYNTHESIS OF FLAVANONE-6-CARBOXYLIC ACID DERIVATIVES FROM SALICYLIC ACID DERIVATIVE

2012 ◽  
Vol 12 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Muhammad Idham Darussalam Mardjan ◽  
Retno Ambarwati ◽  
Sabirin Matsjeh ◽  
Tutik Dwi Wahyuningsih ◽  
Winarto Haryadi
Keyword(s):  
Salicylic Acid ◽  
Carboxylic Acid ◽  
Acid Derivative ◽  
Ring Closure ◽  
Hydroxybenzoic Acid ◽  
Fries Rearrangement ◽  
Acetophenone Derivatives ◽  
Ft Ir ◽  
Benzaldehyde Derivatives ◽  
Derivatives Of

Synthesis of flavanone-6-carboxylic acid derivatives had been conducted via the route of chalcone. The synthesis was carried out from salicylic acid derivative, i.e. 4-hydroxybenzoic acid, via esterification, Fries rearrangement, Claisen-Schmidt condensation and 1,4-nucleophilic addition reactions. Structure elucidation of products was performed using FT-IR, 1H-NMR, GC-MS and UV-Vis spectrometers. Reaction of 4-hydroxybenzoic acid with methanol catalyzed with sulfuric acid produced methyl 4-hydroxybenzoate in 87% yield. The acid-catalyzed-acetylation of the product using acetic anhydride gave methyl 4-acetoxybenzoate in 75% yield. Furthermore, solvent-free Fries rearrangement of methyl 4-acetoxybenzoate in the presence of AlCl3 produced 3-acetyl-4-hydroxybenzoic acid as the acetophenone derivatives in 67% yield. Then, Claisen-Schmidt condensation of the acetophenone and benzaldehyde derivatives of p-anisaldehyde and veratraldehyde in basic condition gave 2'-hydroxychalcone-5'-carboxylic acid derivatives  in 81 and 71 % yield, respectively. Finally, the ring closure reaction of the chalcone yielded the corresponding flavanone-6-carboxylic acids in 67 and 59% yield, respectively.

scholarly journals A salicylic acid derivative extends the lifespan of Caenorhabditis elegans by activating autophagy and the mitochondrial unfolded protein response

Aging Cell ◽  
2018 ◽  
Vol 17 (6) ◽  
pp. e12830 ◽  
Author(s):  
Mehrnaz Shamalnasab ◽  
Simon-Pierre Gravel ◽  
Julie St-Pierre ◽  
Lionel Breton ◽  
Sibylle Jäger ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Caenorhabditis Elegans ◽  
Unfolded Protein Response ◽  
Acid Derivative ◽  
Unfolded Protein ◽  
Protein Response ◽  
Mitochondrial Unfolded Protein Response

Mechanism of action of a lipophilic salicylic acid derivative on normal skin

2004 ◽  
Vol 50 (3) ◽  
pp. P31
Author(s):  
André M Rokugier ◽  
Jean-Luc Leveque ◽  
Gérald Pierard
Keyword(s):  
Salicylic Acid ◽  
Acid Derivative ◽  
Mechanism Of Action ◽  
Normal Skin
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