5.49 Levels of Early-Childhood Behavioral Inhibition Temperament Predict Distinct Neurodevelopmental Pathways to Pediatric Anxiety Symptoms

2018 ◽  
Vol 57 (10) ◽  
pp. S242
Author(s):  
Rany Abend
Keyword(s):  
Early Childhood ◽  
Behavioral Inhibition ◽  
Anxiety Symptoms ◽  
Pediatric Anxiety

scholarly journals Levels of early-childhood behavioral inhibition predict distinct neurodevelopmental pathways to pediatric anxiety

2019 ◽  
Vol 50 (1) ◽  
pp. 96-106 ◽  
Author(s):  
Rany Abend ◽  
Caroline Swetlitz ◽  
Lauren K. White ◽  
Tomer Shechner ◽  
Yair Bar-Haim ◽  
...  
Keyword(s):  
Early Childhood ◽  
Behavioral Inhibition ◽  
Attention Bias ◽  
Anxiety Symptoms ◽  
Childhood And Adolescence ◽  
Cross Sectional ◽  
Linear Mixed Effects ◽  
Pediatric Anxiety ◽  
History Of ◽  
Bias Attention

AbstractBackgroundAnxiety symptoms gradually emerge during childhood and adolescence. Individual differences in behavioral inhibition (BI), an early-childhood temperament, may shape developmental paths through which these symptoms arise. Cross-sectional research suggests that level of early-childhood BI moderates associations between later anxiety symptoms and threat-related amygdala–prefrontal cortex (PFC) circuitry function. However, no study has characterized these associations longitudinally. Here, we tested whether level of early-childhood BI predicts distinct evolving associations between amygdala–PFC function and anxiety symptoms across development.MethodsEighty-seven children previously assessed for BI level in early childhood provided data at ages 10 and/or 13 years, consisting of assessments of anxiety and an fMRI-based dot-probe task (including threat, happy, and neutral stimuli). Using linear-mixed-effects models, we investigated longitudinal changes in associations between anxiety symptoms and threat-related amygdala–PFC connectivity, as a function of early-childhood BI.ResultsIn children with a history of high early-childhood BI, anxiety symptoms became, with age, morenegativelyassociated with right amygdala–left dorsolateral-PFC connectivity when attention was to be maintained on threat. In contrast, with age, low-BI children showed an increasinglypositiveanxiety–connectivity association during the same task condition. Behaviorally, at age 10, anxiety symptoms did not relate to fluctuations in attention bias (attention bias variability, ABV) in either group; by age 13, low-BI children showed a negative anxiety–ABV association, whereas high-BI children showed a positive anxiety–ABV association.ConclusionsEarly-childhood BI levels predict distinct neurodevelopmental pathways to pediatric anxiety symptoms. These pathways involve distinct relations among brain function, behavior, and anxiety symptoms, which may inform diagnosis and treatment.

scholarly journals Infant Attachment Security and Early Childhood Behavioral Inhibition Interact to Predict Adolescent Social Anxiety Symptoms

2014 ◽  
Vol 86 (2) ◽  
pp. 598-613 ◽  
Author(s):  
Erin Lewis-Morrarty ◽  
Kathryn A. Degnan ◽  
Andrea Chronis-Tuscano ◽  
Daniel S. Pine ◽  
Heather A. Henderson ◽  
...  
Keyword(s):  
Early Childhood ◽  
Social Anxiety ◽  
Behavioral Inhibition ◽  
Attachment Security ◽  
Anxiety Symptoms ◽  
Infant Attachment

F28. Levels of Early-Life Behavioral Inhibition Temperament Predict Distinct Neurodevelopmental Pathways to Pediatric Anxiety Symptoms

2018 ◽  
Vol 83 (9) ◽  
pp. S248
Author(s):  
Rany Abend ◽  
Caroline Swetlitz ◽  
Lauren K. White ◽  
Tomer Shechner ◽  
Yair Bar-Haim ◽  
...  
Keyword(s):  
Behavioral Inhibition ◽  
Early Life ◽  
Anxiety Symptoms ◽  
Pediatric Anxiety

scholarly journals Maternal Over-Control Moderates the Association Between Early Childhood Behavioral Inhibition and Adolescent Social Anxiety Symptoms

2012 ◽  
Vol 40 (8) ◽  
pp. 1363-1373 ◽  
Author(s):  
Erin Lewis-Morrarty ◽  
Kathryn A. Degnan ◽  
Andrea Chronis-Tuscano ◽  
Kenneth H. Rubin ◽  
Charissa S. L. Cheah ◽  
...  
Keyword(s):  
Early Childhood ◽  
Social Anxiety ◽  
Behavioral Inhibition ◽  
Anxiety Symptoms

scholarly journals Early childhood social reticence and neural response to peers in preadolescence predict social anxiety symptoms in midadolescence

2019 ◽  
Vol 36 (8) ◽  
pp. 676-689 ◽  
Author(s):  
Tessa Clarkson ◽  
Nicholas R. Eaton ◽  
Eric E. Nelson ◽  
Nathan A. Fox ◽  
Ellen Leibenluft ◽  
...  
Keyword(s):  
Early Childhood ◽  
Social Anxiety ◽  
Neural Response ◽  
Anxiety Symptoms

scholarly journals The BDNF gene val66met polymorphism and behavioral inhibition in early childhood

2018 ◽  
Vol 27 (3) ◽  
pp. 543-554
Author(s):  
Matthew R. J. Vandermeer ◽  
Haroon I. Sheikh ◽  
Shiva S. Singh ◽  
Daniel N. Klein ◽  
Thomas M. Olino ◽  
...  
Keyword(s):  
Early Childhood ◽  
Behavioral Inhibition ◽  
Bdnf Gene ◽  
Val66met Polymorphism

scholarly journals Impact of Behavioral Inhibition and Parenting Style on Internalizing and Externalizing Problems from Early Childhood through Adolescence

2009 ◽  
Vol 37 (8) ◽  
pp. 1063-1075 ◽  
Author(s):  
Lela Rankin Williams ◽  
Kathryn A. Degnan ◽  
Koraly E. Perez-Edgar ◽  
Heather A. Henderson ◽  
Kenneth H. Rubin ◽  
...  
Keyword(s):  
Early Childhood ◽  
Parenting Style ◽  
Behavioral Inhibition ◽  
Externalizing Problems ◽  
Internalizing And Externalizing Problems ◽  
Internalizing And Externalizing

scholarly journals Profiles of behavioral inhibition and anxiety symptoms during the preschool years

2021 ◽  
Vol 39 (1) ◽  
pp. 27-38
Author(s):  
Carina Marques ◽  
Maryse Guedes ◽  
Manuela Veríssimo ◽  
Kenneth H. Rubin ◽  
António J. Santos
Keyword(s):  
Early Intervention ◽  
Social Anxiety ◽  
Behavioral Inhibition ◽  
Anxiety Symptoms ◽  
Anxiety Scale ◽  
Generalized Anxiety ◽  
Physical Injury ◽  
Increased Risk ◽  
Unitary Concept

Behavioral inhibition (BI) during the preschool years can be defined as a biologically-based wariness when exposed to novel people, situations and activities, and has been associated with an increased risk of developing anxiety symptoms. Although BI is not a unitary concept, to date, few studies aimed to characterize different subgroups of children, using multidimensional parental measures, and compare them in terms of anxiety symptoms. This study aimed to identify different profiles of children with BI and explore potential differences concerning anxiety symptoms. One hundred and eight mothers of children with a mean age of 54 months completed the Behavioral Inhibition Questionnaire and the Preschool Anxiety Scale. Two profiles of children were identified: children with high and medium levels of BI. Children with high levels of BI displayed more generalized anxiety, social anxiety and physical injury fears symptoms than children with average BI levels. These differences were of greater magnitude for social anxiety symptoms. These findings highlight the importance of early intervention with children who display high levels of BI as early as the preschool years.

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