4.26 Sustained Attention Deficit in Unaffected Offspring of Parents With Bipolar Disorder

2018 ◽  
Vol 57 (10) ◽  
pp. S213
Author(s):  
Ramandeep S. Kahlon ◽  
Christopher D. Verrico ◽  
Ruchir P. Arvind ◽  
Ajay Shah ◽  
Cristian P. Zeni ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Sustained Attention ◽  
Attention Deficit

Sustained attention deficit in bipolar disorder is not a working memory impairment in disguise

2002 ◽  
Vol 40 (9) ◽  
pp. 1586-1590 ◽  
Author(s):  
Catherine J Harmer ◽  
Luke Clark ◽  
Louise Grayson ◽  
Guy M Goodwin
Keyword(s):  
Bipolar Disorder ◽  
Working Memory ◽  
Sustained Attention ◽  
Attention Deficit ◽  
Memory Impairment

Sustained attention deficit in bipolar disorder

2002 ◽  
Vol 180 (4) ◽  
pp. 313-319 ◽  
Author(s):  
Luke Clark ◽  
Susan D. Iversen ◽  
Guy M. Goodwin
Keyword(s):  
Bipolar Disorder ◽  
Sustained Attention ◽  
Attention Deficit ◽  
Verbal Memory ◽  
Neuropsychological Functioning ◽  
Attentional Set ◽  
Illness Onset ◽  
Affective Symptoms ◽  
Attentional Set Shifting ◽  
Neuropsychological Tasks

BackgroundRecovery in bipolar disorder is central to its definition but is rarely complete. Previous work has suggested that neuropsychological impairment persists during the euthymic state but has been confounded partly by mild affective symptoms in remitted patients.AimsTo characterise neuropsychological functioning in the euthymic phase of bipolar disorder with an emphasis on tasks of executive functioning.MethodThirty euthymic patients with bipolar disorder were compared with thirty healthy controls on neuropsychological tasks differentially sensitive to damage within prefrontal cortex.ResultsBipolar I patients were impaired on tasks of attentional set shifting, verbal memory and sustained attention. Only sustained attention deficit survived controlling for mild affective symptoms. This deficit was related to progression of illness, but was none the less present in a subgroup of patients near illness onset.ConclusionsSustained attention deficit may represent a neuropsychological vulnerability marker for bipolar disorder, providing a focus for further understanding of the phenotype and analysis of the neuronal networks involved.

Attention-deficit/hyperactivity disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder

2021 ◽  
pp. 1-8
Author(s):  
L. Propper ◽  
A. Sandstrom ◽  
S. Rempel ◽  
E. Howes Vallis ◽  
S. Abidi ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Attention Deficit Hyperactivity Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Mood Disorder ◽  
Attention Deficit ◽  
Neurodevelopmental Disorders ◽  
Autism Spectrum ◽  
Major Depressive ◽  
Hyperactivity Disorder

Abstract Background Offspring of parents with major mood disorders (MDDs) are at increased risk for early psychopathology. We aim to compare the rates of neurodevelopmental disorders in offspring of parents with bipolar disorder, major depressive disorder, and controls. Method We established a lifetime diagnosis of neurodevelopmental disorders [attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, communication disorders, intellectual disabilities, specific learning disorders, and motor disorders] using the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version in 400 participants (mean age 11.3 + s.d. 3.9 years), including 93 offspring of parents with bipolar disorder, 182 offspring of parents with major depressive disorder, and 125 control offspring of parents with no mood disorder. Results Neurodevelopmental disorders were elevated in offspring of parents with bipolar disorder [odds ratio (OR) 2.34, 95% confidence interval (CI) 1.23–4.47, p = 0.010] and major depressive disorder (OR 1.87, 95% CI 1.03–3.39, p = 0.035) compared to controls. This difference was driven by the rates of ADHD, which were highest among offspring of parents with bipolar disorder (30.1%), intermediate in offspring of parents with major depressive disorder (24.2%), and lowest in controls (14.4%). There were no significant differences in frequencies of other neurodevelopmental disorders between the three groups. Chronic course of mood disorder in parents was associated with higher rates of any neurodevelopmental disorder and higher rates of ADHD in offspring. Conclusions Our findings suggest monitoring for ADHD and other neurodevelopmental disorders in offspring of parents with MDDs may be indicated to improve early diagnosis and treatment.

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