Suicide Attempts in Juvenile Bipolar Versus Major Depressive Disorders: Systematic Review and Meta-Analysis

2017 ◽  
Vol 56 (10) ◽  
pp. 825-831.e3 ◽  
Author(s):  
Franco De Crescenzo ◽  
Giulia Serra ◽  
Francesco Maisto ◽  
Mai Uchida ◽  
Hilary Woodworth ◽  
...  
Keyword(s):  
Systematic Review ◽  
Depressive Disorders ◽  
Suicide Attempts ◽  
Meta Analysis ◽  
Major Depressive ◽  
Major Depressive Disorders

scholarly journals Systematic review and meta-analysis of the prevalence of depressive symptoms, dysthymia and major depressive disorders among homeless people

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e040061
Author(s):  
Getinet Ayano ◽  
Asmare Belete ◽  
Bereket Duko ◽  
Light Tsegay ◽  
Berihun Assefa Dachew
Keyword(s):  
Systematic Review ◽  
Depressive Symptoms ◽  
Depressive Disorders ◽  
Meta Analysis ◽  
Random Effect ◽  
Homeless People ◽  
Sensitivity Analyses ◽  
Prevalence Rates ◽  
Major Depressive ◽  
Major Depressive Disorders

ObjectivesTo assess the global prevalence estimates of depressive symptoms, dysthymia and major depressive disorders (MDDs) among homeless people.DesignSystematic review and meta-analysis.Data sourcesDatabases including PubMed, Scopus and Web of Science were systematically searched up to February 2020 to identify relevant studies that have reported data on the prevalence of depressive symptoms, dysthymia and MDDs among homeless people.Eligibility criteriaOriginal epidemiological studies written in English that addressed the prevalence of depressive problems among homeless people.Data extraction and synthesisA random-effect meta-analysis was performed to pool the prevalence estimated from individual studies. Subgroup and sensitivity analyses were employed to compare the prevalence across the groups as well as to identify the source of heterogeneities. The Joanna Briggs Institute’s quality assessment checklist was used to measure the study quality. Cochran’s Q and the I2 test were used to assess heterogeneity between the studies.ResultsForty publications, including 17 215 participants, were included in the final analysis. This meta-analysis demonstrated considerably higher prevalence rates of depressive symptoms 46.72% (95% CI 37.77% to 55.90%), dysthymia 8.25% (95% CI 4.79% to 11.86%), as well as MDDs 26.24% (95% CI 21.02% to 32.22%) among homeless people. Our subgroup analysis showed that the prevalence of depressive symptoms was high among younger homeless people (<25 years of age), whereas the prevalence of MDD was high among older homeless people (>50 years of age) when compared with adults (25–50 years).ConclusionThis review showed that nearly half, one-fourth and one-tenth of homeless people are suffering from depressive symptoms, dysthymia and MDDs, respectively, which are notably higher than the reported prevalence rates in the general population. The findings suggest the need for appropriate mental health prevention and treatment strategies for this population group.

scholarly journals The excess costs of depression: a systematic review and meta-analysis

2019 ◽  
Vol 29 ◽  
Author(s):  
H. König ◽  
H.-H. König ◽  
A. Konnopka
Keyword(s):  
Systematic Review ◽  
Full Text ◽  
Depressive Disorders ◽  
Meta Analysis ◽  
Indirect Costs ◽  
Major Depressive ◽  
Somatic Disease ◽  
Excess Costs ◽  
Major Depressive Disorders ◽  
Study Participants

Abstract Aims Major depressive disorders are highly prevalent in the world population, contribute substantially to the global disease burden and cause high health care expenditures. Information on the economic impact of depression, as provided by cost-of-illness (COI) studies, can support policymakers in the decision-making regarding resource allocation. Although the literature on COI studies of depression has already been reviewed, there is no quantitative estimation of depression excess costs across studies yet. Our aims were to systematically review COI studies of depression with comparison group worldwide and to assess the excess costs of depression in adolescents, adults, elderly, and depression as a comorbidity of a primary somatic disease quantitatively in a meta-analysis. Methods We followed the PRISMA reporting guidelines. PubMed, PsycINFO, NHS EED, and EconLit were searched without limitations until 27/04/2018. English or German full-text peer-reviewed articles that compared mean costs of depressed and non-depressed study participants from a bottom-up approach were included. We only included studies reporting costs for major depressive disorders. Data were pooled using a random-effects model and heterogeneity was assessed with I2 statistic. The primary outcome was ratio of means (RoM) of costs of depressed v. non-depressed study participants, interpretable as the percentage change in mean costs between the groups. Results We screened 12 760 articles by title/abstract, assessed 393 articles in full-text and included 48 articles. The included studies encompassed in total 55 898 depressed and 674 414 non-depressed study participants. Meta-analysis showed that depression was associated with higher direct costs in adolescents (RoM = 2.79 [1.69–4.59], p < 0.0001, I2 = 87%), in adults (RoM = 2.58 [2.01–3.31], p < 0.0001, I2 = 99%), in elderly (RoM = 1.73 [1.47–2.03], p < 0.0001, I2 = 73%) and in participants with comorbid depression (RoM = 1.39 [1.24–1.55], p < 0.0001, I2 = 42%). In addition, we conducted meta-analyses for inpatient, outpatient, medication and emergency costs and a cost category including all other direct cost categories. Meta-analysis of indirect costs showed that depression was associated with higher costs in adults (RoM = 2.28 [1.75–2.98], p < 0.0001, I2 = 74%). Conclusions This work is the first to provide a meta-analysis in a global systematic review of COI studies for depression. Depression was associated with higher costs in all age groups and as comorbidity. Pooled RoM was highest in adolescence and decreased with age. In the subgroup with depression as a comorbidity of a primary somatic disease, pooled RoM was lower as compared to the age subgroups. More evidence in COI studies for depression in adolescence and for indirect costs would be desirable.

scholarly journals Mixed states in bipolar and major depressive disorders: systematic review and quality appraisal of guidelines

2018 ◽  
Vol 138 (3) ◽  
pp. 196-222 ◽  
Author(s):  
N. Verdolini ◽  
D. Hidalgo-Mazzei ◽  
A. Murru ◽  
I. Pacchiarotti ◽  
L. Samalin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Depressive Disorders ◽  
Mixed States ◽  
Quality Appraisal ◽  
Major Depressive ◽  
Major Depressive Disorders

scholarly journals Gray and white matter differences in adolescents and young adults with prior suicide attempts across bipolar and major depressive disorders

2019 ◽  
Vol 245 ◽  
pp. 1089-1097 ◽  
Author(s):  
Siyan Fan ◽  
Elizabeth T.C. Lippard ◽  
Anjali Sankar ◽  
Amanda Wallace ◽  
Jennifer A.Y. Johnston ◽  
...  
Keyword(s):  
Young Adults ◽  
White Matter ◽  
Depressive Disorders ◽  
Suicide Attempts ◽  
Adolescents And Young Adults ◽  
Major Depressive ◽  
Major Depressive Disorders
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