2.20 RESTING-STATE CEREBRAL BLOOD FLOW IN THE SUPERIOR TEMPORAL SULCUS CORRELATES WITH SOCIAL PERCEPTION IMPAIRMENTS IN CHILDREN WITH AUTISM SPECTRUM DISORDER

2016 ◽  
Vol 55 (10) ◽  
pp. S127
Author(s):  
Ana Saitovitch ◽  
Elza Rechtman ◽  
Hervé Lemaitre ◽  
Elise Douard ◽  
Nadia Chabane ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Social Perception ◽  
Resting State ◽  
Children With Autism ◽  
Superior Temporal Sulcus ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Abnormal maturation of the resting‐state peak alpha frequency in children with autism spectrum disorder

2019 ◽  
Vol 40 (11) ◽  
pp. 3288-3298 ◽  
Author(s):  
J. Christopher Edgar ◽  
Marissa Dipiero ◽  
Emma McBride ◽  
Heather L. Green ◽  
Jeffrey Berman ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Resting State ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Alpha Frequency

scholarly journals A-098 Regional Cerebral Blood Flow in Adults with Autism

2020 ◽  
Vol 35 (6) ◽  
pp. 891-891
Author(s):  
Mcdonald B ◽  
Golden C ◽  
Willeumier K ◽  
Amen D
Keyword(s):  
Autism Spectrum Disorder ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Basal Ganglia ◽  
Regional Cerebral Blood Flow ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Healthy Controls ◽  
Regional Cerebral Blood ◽  
Motor Behaviors

Abstract Objective To identify regional cerebral blood flow (rCBF) differences between individuals with Autism Spectrum Disorder and healthy controls. Method Healthy controls [n = 81, Mage = 41.9, 53.0% female] and persons diagnosed by psychiatric examination with Autism Spectrum Disorder (ASD) [n = 62, Mage = 29.8, 75.8% male] were selected from a deidentified adult clinical outpatient database. Those with comorbid diagnoses were included. Significant differences (alpha = .001) were found for gender [χ(2) = 13.4] and age [t(141) = −4.8] between groups. Multiple ANCOVA controlled for gender and age on outcomes of rCBF across 17 brain regions from Single-Photon Emission Computed Tomography (SPECT) were analyzed. Results Significant rCBF differences were noted in the cerebellum [left:F(1,143) = 9.43, p = .003; right: F(1,143) = 14.2, p < .001] and basal ganglia [left:F(1,143) = 8.2,p = .005; right:F(1,143) = 10.3, p = .002]. Group means comparisons indicated higher perfusion in the cerebellum and lower perfusion in the basal ganglia in the group with ASD. No significant differences were found bilaterally in limbic system, motor sensory strip, vermis, or occipital, parietal, frontal, or temporal lobes. Conclusion Results indicated that individuals diagnosed with ASD have diminished rCBF in the basal ganglia and increased rCBF in the cerebellum. Previous research supports these conclusions, as the basal ganglia is linked with repetitive and/or restricted motor behaviors, and the cerebellum aids in understanding gross motor and coordination in ASD, as well as social interactions, and language and communication. By understanding the underlying mechanisms of ASD, interventions focused on sensory-motor abilities, such as sensory enrichment (Woo and Leon, 2013), can show a decrease in motor behaviors and improve cognition. Future studies should control for potential comorbidities, the severity of ASD, and medication usage.

scholarly journals Sex Differences in the Amygdala Resting-State Connectome of Children With Autism Spectrum Disorder

2020 ◽  
Vol 5 (3) ◽  
pp. 320-329 ◽  
Author(s):  
Joshua K. Lee ◽  
David G. Amaral ◽  
Marjorie Solomon ◽  
Sally J. Rogers ◽  
Sally Ozonoff ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Sex Differences ◽  
Resting State ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Children with Autism Spectrum Disorder Demonstrate Regionally Specific Altered Resting-State Phase–Amplitude Coupling

2019 ◽  
Vol 9 (5) ◽  
pp. 425-436
Author(s):  
Russell G. Port ◽  
Marissa A. Dipiero ◽  
Matthew Ku ◽  
Song Liu ◽  
Lisa Blaskey ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Resting State ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Phase Amplitude

Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ

2011 ◽  
Vol 42 (2) ◽  
pp. 313-318 ◽  
Author(s):  
Marco Pagani ◽  
Irina Manouilenko ◽  
Sharon Stone-Elander ◽  
Richard Odh ◽  
Dario Salmaso ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Adults With Autism ◽  
Pet Ct

Neurobiological Substrate of Autism Spectrum Disorder - Cerebral Blood Flow Distribution of 11C-butanol as Assessed by PET/CT

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
M. Pagani ◽  
I. Manouilenko ◽  
S. Stone-Elander ◽  
R. Odh ◽  
D. Salmaso ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Statistical Parametric Mapping ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Healthy Controls ◽  
Associative Cortex ◽  
Examination Time ◽  
Pet Ct

Background:Functional studies in Autism Spectrum Disorder (ASD) have shown localised focal hypoperfusion and abnormalities in the anatomo-functional connectivity of limbic-striatal “social” brain. However, no common regional abnormalities have been found across studies.The aim of this study was to investigate the cerebral blood flow (CBF) at rest in subjects with ASD as compared to a group of healthy controls.Methods:In this preliminary investigation six normal intelligence patients with ASD and 5 age and sex matched healthy controls (HC) were examined using PET/CT camera and, as CBF tracer, 11C-butanol, a radiopharmaceutical produced on-site. The combination of these two methodologies reduced the whole examination time to less than 10 minutes. Statistical Parametric Mapping was implemented to analyse the data.Results:As compared to HC, ASD showed a highly significant CBF increase (height threshold p=0.001, p< 0.0001 at voxel-level), bilaterally, in large portions of the cerebellum, of the visual associative cortex and of the posterior parietal lobe.Conclusions:This preliminary study was performed by the state-of-the-art neuroimaging methodologies that reduced considerably the examination time and resulted in less stress and more reliable investigations. The occipital and parietal associative cortex as well as the cerebellum showed an increased CBF in ASD, underscoring their involvement in the disease and raising methodological and diagnostic issues to be considered when exploring the neuroanatomy of ASD.

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