1.21 GREY MATTER VOLUME ABNORMALITIES WERE ASSOCIATED WITH AUTISTIC SYMPTOMS IN 5- TO 12-YEAR-OLD LOW-FUNCTION CHILDREN WITH AUTISM SPECTRUM DISORDER: A VBM-DARTEL STUDY

2016 ◽  
Vol 55 (10) ◽  
pp. S106
Author(s):  
Jia Cai ◽  
Xiao Hu ◽  
Kuifang Guo ◽  
Pingyuan Yang ◽  
Mingjin Situ ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Grey Matter ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Grey Matter Volume ◽  
Matter Volume ◽  
Autistic Symptoms

scholarly journals Decreased grey matter volumes in unaffected mothers of individuals with autism spectrum disorder reflect the broader autism endophenotype

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kyung-min An ◽  
Takashi Ikeda ◽  
Tetsu Hirosawa ◽  
Ken Yaoi ◽  
Yuko Yoshimura ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Grey Matter ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Parahippocampal Gyrus ◽  
Middle Temporal Gyrus ◽  
Grey Matter Volume ◽  
Temporoparietal Junction ◽  
Middle Temporal ◽  
Matter Volume

AbstractAutism spectrum disorder (ASD) is a neurodevelopmental disorder with an early onset and a strong genetic origin. Unaffected relatives may present similar but subthreshold characteristics of ASD. This broader autism phenotype is especially prevalent in the parents of individuals with ASD, suggesting that it has heritable factors. Although previous studies have demonstrated brain morphometry differences in ASD, they are poorly understood in parents of individuals with ASD. Here, we estimated grey matter volume in 45 mothers of children with ASD (mASD) and 46 age-, sex-, and handedness-matched controls using whole-brain voxel-based morphometry analysis. The mASD group had smaller grey matter volume in the right middle temporal gyrus, temporoparietal junction, cerebellum, and parahippocampal gyrus compared with the control group. Furthermore, we analysed the correlations of these brain volumes with ASD behavioural characteristics using autism spectrum quotient (AQ) and systemizing quotient (SQ) scores, which measure general autistic traits and the drive to systemize. Smaller volumes in the middle temporal gyrus and temporoparietal junction correlated with higher SQ scores, and smaller volumes in the cerebellum and parahippocampal gyrus correlated with higher AQ scores. Our findings suggest that atypical grey matter volumes in mASD may represent one of the neurostructural endophenotypes of ASD.

scholarly journals Motor atypicalities in infancy are associated with general developmental level at 2 years, but not autistic symptoms

Autism ◽  
2020 ◽  
Vol 24 (7) ◽  
pp. 1650-1663 ◽  
Author(s):  
Sheila Achermann ◽  
Pär Nyström ◽  
Sven Bölte ◽  
Terje Falck-Ytter
Keyword(s):  
Autism Spectrum Disorder ◽  
Motion Capture ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Developmental Level ◽  
Infant Siblings ◽  
Motor Functioning ◽  
History Of ◽  
Autistic Symptoms

Atypical motor development has frequently been reported in infants at elevated likelihood for autism spectrum disorder. However, no previous study has used detailed motion capture technology to compare infant siblings of children with autism spectrum disorder and infant siblings with no familial history of autism spectrum disorder. We investigated reaching movements during an interceptive action task in 10-month-old infants using kinematic data with high spatiotemporal resolution. The results indicated that several measures were different in infants at elevated likelihood. However, longitudinal analyses revealed that while specific infant motor measures (e.g. number of movement units) were related to broad measures of general developmental level in toddlerhood, the associations with later autism spectrum disorder symptomatology were not significant. These findings confirm that some aspects of motor functioning are atypical in infants at elevated likelihood for autism spectrum disorder, but provide no support for the view that these issues are specifically linked to autism spectrum disorder symptoms, but may rather reflect neurodevelopment more generally. Lay abstract Atypicalities in motor functioning are often observed in later born infant siblings of children with autism spectrum disorder. The goal of our study was to investigate motor functioning in infants with and without familial history of autism spectrum disorder. Specifically, we investigated how infants catch a ball that is rolling toward them following a non-straight path, a task that requires both efficient planning and execution. Their performance was measured using detailed three-dimensional motion capture technology. We found that several early motor functioning measures were different in infants with an older autistic sibling compared to controls. However, these early motor measures were not related to autistic symptoms at the age of 2 years. Instead, we found that some of the early motor measures were related to their subsequent non-social, general development. The findings of our study help us understand motor functioning early in life and how motor functioning is related to other aspects of development.

scholarly journals Children With Autism Spectrum Disorder and Neurodevelopmental Regression Present a Severe Pattern After a Follow-Up at 24 Months

2021 ◽  
Vol 12 ◽  
Author(s):  
Pilar Martin-Borreguero ◽  
Antonio Rafael Gómez-Fernández ◽  
Maria Jose De La Torre-Aguilar ◽  
Mercedes Gil-Campos ◽  
Katherine Flores-Rojas ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Pervasive Developmental Disorders ◽  
Rating Scale ◽  
Clinical Manifestations ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Autistic Symptoms ◽  
Battelle Developmental Inventory

This study examined the presence of neurodevelopmental regression and its effects on the clinical manifestations and the severity of autism spectrum disorder (ASD) in a group of children with autism compared with those without neurodevelopmental regression at the time of initial classification and subsequently.Methods and Subjects: ASD patients were classified into two subgroups, neurodevelopmental regressive (AMR) and non-regressive (ANMR), using a questionnaire based on the Autism Diagnostic Interview-Revised test. The severity of ASD and neurodevelopment were assessed with the Childhood Autism Rating Scale Test-2, Strengths and Difficulties Questionnaire, and Pervasive Developmental Disorders Behavior Inventory Parent Ratings (PDDBI) and with the Battelle Developmental Inventory tests at the beginning of the study and after 24 months of follow-up. Fifty-two patients aged 2–6 years with ASD were included. Nineteen were classified with AMR, and 33 were classified with ANMR.Results: The AMR subgroup presented greater severity of autistic symptoms and higher autism scores. Additionally, they showed lower overall neurodevelopment. The AMR subgroup at 24 months had poorer scores on the Battelle Developmental Inventory test in the following areas: Total personal/social (p < 0.03), Total Motor (p < 0.04), Expressive (p < 0.01), and Battelle Total (p < 0.04). On the PDDBI test, the AMR subgroup had scores indicating significantly more severe ASD symptoms in the variables: ritual score (p < 0.038), social approach behaviors (p < 0.048), expressive language (p < 0.002), and autism score (p < 0.003).Conclusions: ASD patients exhibited a set of different neurological phenotypes. The AMR and ANMR subgroups presented different clinical manifestations and prognoses in terms of the severity of autistic symptoms and neurodevelopment.

scholarly journals Correlation Between Screen Time and Autistic Symptoms as Well as Development Quotients in Children With Autism Spectrum Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Han-Yu Dong ◽  
Bing Wang ◽  
Hong-Hua Li ◽  
Xiao-Jing Yue ◽  
Fei-Yong Jia
Keyword(s):  
Autism Spectrum Disorder ◽  
Screen Time ◽  
Rating Scale ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Vital Role ◽  
Spectrum Disorder ◽  
Children With Asd ◽  
Younger Age ◽  
Autistic Symptoms

Background: Electronic screen media play an increasingly vital role in children's entertainment; however, excessive screen time may negatively influence child development. The purpose of this study was to investigate the relationship between the screen time of children with autism spectrum disorder (ASD) and their autistic symptoms and development quotients (DQs).Methods: We compared the screen time of 101 children with ASD and 57 typically developing (TD) children. Then, we performed a correlation analysis to determine the correlations between the screen time and the ASD-related scale scores and developmental quotients of the Gesell Developmental Schedules (GDS) of ASD children. We further divided the ASD group into subgroups according to the screen time and age and then separately conducted the above correlation analyses by subgroup.Result: The results showed that the screen time of the children with ASD was longer than that of the TD children (3.34 ± 2.64 h vs. 0.91 ± 0.93 h). The screen time of the children with ASD was positively correlated with the Childhood Autism Rating Scale (CARS) score (r = 0.242, P = 0.021) and “taste, smell and touch” item of CARS(r = 0.304, P = 0.005), and negatively correlated with the language DQ of the GDS (r = −0.236, P = 0.047). The subgroup analysis showed that in the longer screen time subgroup of ASD children, the screen time was positively correlated with the CARS score (r = 0.355, P = 0.026) and negatively correlated with the DQs of all domains of the GDS (P < 0.05). In addition, in the younger age group of ASD children, the screen time was positively correlated with the CARS score (r = 0.314, P = 0.021) and negatively correlated with the DQs of all domains of the GDS, except for the personal-social behavior domain (P < 0.05).Conclusion: Compared with TD children, children with ASD have a longer screen time. The screen time is related to autism-like symptoms and the DQs of children with ASD. The longer the screen time, the more severe the symptoms of ASD (especially sensory symptoms), and the more obvious the developmental delay, especially in ASD children with a longer screen time and younger age, particularly in the language domain.

Sign in / Sign up

Export Citation Format

Share Document