30.4 PILOT STUDY OF AN ORAL ORTHOTIC IN REDUCING TIC SEVERITY IN CHRONIC TIC DISORDER AND TOURETTE'S DISORDER

2016 ◽  
Vol 55 (10) ◽  
pp. S305
Author(s):  
Shannon M. Bennett ◽  
Jeffrey Hindin ◽  
Justin W. Mohatt ◽  
John T. Walkup
Keyword(s):  
Pilot Study ◽  
Tourette’S Disorder ◽  
Tic Disorder ◽  
Tourette's Disorder ◽  
Chronic Tic Disorder ◽  
Tic Severity

scholarly journals Effect of behavior therapy for Tourette's disorder on psychiatric symptoms and functioning in adults

2019 ◽  
Vol 50 (12) ◽  
pp. 2046-2056 ◽  
Author(s):  
Joseph F. McGuire ◽  
Emily J. Ricketts ◽  
Lawrence Scahill ◽  
Sabine Wilhelm ◽  
Douglas W. Woods ◽  
...  
Keyword(s):  
Behavior Therapy ◽  
Functional Outcomes ◽  
Psychiatric Symptoms ◽  
Supportive Therapy ◽  
Repeated Measure ◽  
Tourette’S Disorder ◽  
Tourette's Disorder ◽  
Chronic Tic Disorder ◽  
Tic Severity

AbstractBackgroundAlthough behavior therapy reduces tic severity, it is unknown whether it improves co-occurring psychiatric symptoms and functional outcomes for adults with Tourette's disorder (TD). This information is essential for effective treatment planning. This study examined the effects of behavior therapy on psychiatric symptoms and functional outcomes in older adolescents and adults with TD.MethodA total of 122 individuals with TD or a chronic tic disorder participated in a clinical trial comparing behavior therapy to psychoeducation and supportive therapy. At baseline, posttreatment, and follow-up visits, participants completed assessments of tic severity, co-occurring symptoms (inattention, impulsiveness, hyperactivity, anger, anxiety, depression, obsessions, and compulsions), and psychosocial functioning. We compared changes in tic severity, psychiatric symptoms, and functional outcomes using repeated measure and one-way analysis of variance.ResultsAt posttreatment, participants receiving behavior therapy reported greater reductions in obsessions compared to participants in supportive therapy ($\eta _p^2 $ = 0.04, p = 0.04). Across treatments, a positive treatment response on the Clinical Global Impression of Improvement scale was associated with a reduced disruption in family life ($\eta _p^2 $ = 0.05, p = 0.02) and improved functioning in a parental role ($\eta _p^2 $ = 0.37, p = 0.02). Participants who responded positively to eight sessions of behavior therapy had an improvement in tic severity ($\eta _p^2 $ = 0.75, p < 0.001), inattention ($\eta _p^2 $ = 0.48, p < 0.02), and functioning ($\eta _p^2 $ = 0.39–0.42, p < 0.03–0.04) at the 6-month follow-up.ConclusionBehavior therapy has a therapeutic benefit for co-occurring obsessive symptoms in the short-term, and reduces tic severity and disability in adults with TD over time. Additional treatments may be necessary to address co-occurring symptoms and improve functional outcomes.

scholarly journals Case Report: DSM–5 misses an edge case in tic disorders nosology

F1000Research ◽  
2020 ◽  
Vol 9 ◽  
pp. 505
Author(s):  
Kevin J. Black
Keyword(s):  
Case Report ◽  
Tic Disorders ◽  
Tourette’S Disorder ◽  
Tic Disorder ◽  
Statistical Manual ◽  
Tourette's Disorder ◽  
Diagnostic And Statistical Manual ◽  
Dsm 5

A boy with multiple phonic tics, one lifetime motor tic, and no impairment or marked distress does not meet criteria for any DSM–5 tic disorder diagnosis. The next version of the Diagnostic and Statistical Manual should adjust the criteria for Tourette's Disorder and/or for "other specified tic disorder" and "unspecified tic disorder."

scholarly journals Effectiveness of behaviour therapy for children and adolescents with Tourette syndrome and chronic tic disorder in a real-world setting

2020 ◽  
Author(s):  
Per Andrén ◽  
Vera Wachtmeister ◽  
Julia Franzé ◽  
Caroline Speiner ◽  
Lorena Fernández de la Cruz ◽  
...  
Keyword(s):  
Young People ◽  
Tourette Syndrome ◽  
Real World ◽  
Post Treatment ◽  
Reversal Training ◽  
Behaviour Therapy ◽  
Tic Disorder ◽  
Chronic Tic Disorder ◽  
Habit Reversal Training ◽  
Tic Severity

Background: Treatment guidelines recommend behaviour therapy (BT) as the first-line intervention for patients with Tourette syndrome (TS) and chronic tic disorder (CTD). The efficacy of BT has been documented in randomised controlled trials (RCTs), but it is unclear to what extent these results are generalisable to real-world clinical settings, and whether the therapeutic gains are maintained long-term.Methods: In this naturalistic study, 74 young people with TS/CTD (aged 6 to 17) received BT (including psychoeducation, exposure with response prevention, habit reversal training or a combination of these treatments) at a specialist clinic in Stockholm, Sweden. Data were routinely collected at baseline, post-treatment, and at 3-, 6-, and 12-month follow-ups. Measures included the clinician-rated Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impression – Improvement scale (CGI-I), amongst others.Results: Tic severity and tic-related impairment (as measured by the YGTSS) improved significantly after treatment, with large within-group effect sizes (d=1.03 for the YGTSS Total Tic Severity Score, and d=1.37 for the YGTSS Impairment Score). At post-treatment, 57% of the participants were classified as treatment responders according to the CGI-I. Both tic severity and tic-related impairment continued to improve further through the follow-up, with 75% of the participants being rated as responders 12 months after the end of treatment. Significant improvements were also observed across a range of secondary measures.Conclusions: BT is an effective and durable treatment for young people with TS/CTD in a real-world clinical setting, with effects comparable to those reported in RCTs.

4.14 A PILOT STUDY OF SD-809 (DEUTETRABENAZINE) IN TICS ASSOCIATED WITH TOURETTE'S DISORDER

2016 ◽  
Vol 55 (10) ◽  
pp. S167
Author(s):  
Joseph Jankovic ◽  
Joohi Jimenez-Shahed ◽  
Cathy Budman ◽  
Barbara J. Coffey ◽  
Tanya K. Murphy ◽  
...  
Keyword(s):  
Pilot Study ◽  
Tourette’S Disorder ◽  
Tourette's Disorder

scholarly journals Evaluation of a cognitive psychophysiological model for management of tic disorders: an open trial

2016 ◽  
Vol 209 (1) ◽  
pp. 76-83 ◽  
Author(s):  
Kieron O'Connor ◽  
Marc Lavoie ◽  
Pierre Blanchet ◽  
Marie-Ève St-Pierre-Delorme
Keyword(s):  
Tourette Syndrome ◽  
Self Esteem ◽  
Current Treatment ◽  
Open Trial ◽  
Tic Disorders ◽  
Tic Disorder ◽  
Chronic Tic Disorder ◽  
Tic Severity ◽  
Sensorimotor Processes

BackgroundTic disorders, in particular chronic tic disorder and Tourette syndrome, affect about 1% of the population. The current treatment of choice is pharmacological or behavioural, addressing tics or the premonitory urges preceding tic onset.AimsThe current study reports an open trial evaluating the effectiveness of a cognitive psychophysiological treatment addressing Tourette-specific sensorimotor activation processes rather than the tic.MethodForty-nine people with Tourette syndrome and 36 people with chronic tics completed 10 weeks of individual cognitive psychophysiological therapy. Outcome measures included two tic severity scales and psychosocial measures.ResultsPost-treatment both groups had significantly improved on the tic scales with strong effect sizes across tic locations and complex and simple tics, maintained at 6-month follow-up with further change in perfectionism and self-esteem.ConclusionsThe cognitive psychophysiological approach targeting underlying sensorimotor processes rather than tics in Tourette's and chronic tic disorder reduced symptoms with a large effect size.

The role of affect lability on tic severity and impairment in youth with Tourette's disorder

2020 ◽  
Vol 27 ◽  
pp. 100578
Author(s):  
Kesley A. Ramsey ◽  
Joey Ka-Yee Essoe ◽  
Eric A. Storch ◽  
Adam B. Lewin ◽  
Tanya K. Murphy ◽  
...  
Keyword(s):  
Tourette’S Disorder ◽  
Tourette's Disorder ◽  
Tic Severity

scholarly journals Predicting Clinical Course from Subcortical Shape in Provisional Tic Disorder

2021 ◽  
Author(s):  
Tiffanie Che ◽  
Soyoung Kim ◽  
Deanna J. Greene ◽  
Ashley Heywood ◽  
Jimin Ding ◽  
...  
Keyword(s):  
Tic Disorders ◽  
Healthy Controls ◽  
Linear Regression Models ◽  
Tic Disorder ◽  
Surface Maps ◽  
Chronic Tic Disorder ◽  
Tic Severity ◽  
Group A ◽  
Diffeomorphic Metric Mapping

The ongoing NewTics study examines children who have had tics for less than 9 months (NT group) - a population on which little research exists. Here, we further investigate relationships between subcortical shape and tic symptom outcomes. 138 children were assessed at baseline and a 12-month follow-up: 79 with NT, 27 tic-free healthy controls (HC), and 32 with chronic tic disorder or Tourette syndrome (TS), using T1-weighted MRI and total tic scores (TTS) from the Yale Global Tic Severity Scale to evaluate symptom change. Subcortical surface maps were generated using FreeSurfer-initialized large deformation diffeomorphic metric mapping, and linear regression models were constructed to correlate structural shapes with TTS while accounting for covariates, with relationships mapped onto structure surfaces. When compared to healthy controls, smaller mean volumes were found in the TS group for the caudate, nucleus accumbens, pallidum, and thalamus. NT had smaller mean volumes than controls in the caudate, pallidum, and thalamus. Surface maps illustrate distinct patterns of inward deformation (localized volume loss) in the TS group compared to NT children. In the NT group, a larger hippocampus at baseline significantly correlated with the worsening of tic symptoms at 12 months. Outward deformation in the hippocampus and inward deformation in the accumbens at baseline are also related to worsening tic symptoms at follow-up. Since the NT group has had tics only for a few months, we can rule out the possibility that these subcortical volume differences are caused by living with tics for years; they are more likely related to the cause of tics. These observations constitute some of the first prognostic biomarkers for tic disorders and suggest localized circuitry that may be associated with outcome of tic disorders.

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