scholarly journals 10.3 Altered Intrinsic Functional Brain Architecture in Children at Familial Risk of Major Depression

2016 ◽  
Vol 55 (10) ◽  
pp. S272-S273
Author(s):  
Mai Uchida
Keyword(s):  
Major Depression ◽  
Familial Risk ◽  
Functional Brain ◽  
Brain Architecture

scholarly journals Altered Intrinsic Functional Brain Architecture in Children at Familial Risk of Major Depression

2016 ◽  
Vol 80 (11) ◽  
pp. 849-858 ◽  
Author(s):  
Xiaoqian J. Chai ◽  
Dina Hirshfeld-Becker ◽  
Joseph Biederman ◽  
Mai Uchida ◽  
Oliver Doehrmann ◽  
...  
Keyword(s):  
Major Depression ◽  
Familial Risk ◽  
Functional Brain ◽  
Brain Architecture

scholarly journals Altered intrinsic functional brain architecture in children at familial risk of major depression

2016 ◽  
Vol 26 ◽  
pp. S714-S715
Author(s):  
J. Biederman ◽  
M. Uchida ◽  
X. Chai ◽  
D. Hirshfeld-Becker ◽  
S. Whitfield-Gabrieli ◽  
...  
Keyword(s):  
Major Depression ◽  
Familial Risk ◽  
Functional Brain ◽  
Brain Architecture

FUNCTIONAL BRAIN ARCHITECTURE PREDICTS LONGITUDINAL TAU SPREADING IN ALZHEIMER’S DISEASE

2019 ◽  
Vol 15 (7) ◽  
pp. P1610-P1611
Author(s):  
Nicolai Franzmeier ◽  
Julia Neitzel ◽  
Anna Rubinski ◽  
Michael Ewers
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Brain ◽  
Brain Architecture

scholarly journals Reliability of a lifetime history of major depression: implications for heritability and co-morbidity

1998 ◽  
Vol 28 (4) ◽  
pp. 857-870 ◽  
Author(s):  
D. L. FOLEY ◽  
M. C. NEALE ◽  
K. S. KENDLER
Keyword(s):  
Major Depression ◽  
Structural Equation ◽  
Structural Equation Models ◽  
Familial Risk ◽  
Ratio Test ◽  
Psychiatric Interview ◽  
Lifetime History ◽  
Co Morbidity ◽  
Familial Influences ◽  
History Of

Background. In unselected samples, the diagnosis of major depression (MD) is not highly reliable. It is not known if occasion-specific influences on reliability index familial risk factors for MD, or how reliability is associated with risk for co-morbid anxiety disorders.Methods. An unselected sample of 847 female twin pairs was interviewed twice, 5 years apart, about their lifetime history (LTH) of MD, generalized anxiety disorder (GAD) and panic disorder (PD). Familial influences on reliability were examined using structural equation models. Logistic regression was used to identify clinical features that predict reliable diagnosis. Co-morbidity was characterized using the continuation ratio test.Results. The reliability of a LTH of MD over 5 years was fair (κ=0·43). There was no evidence for occasion-specific familial influences on reliability, and heritability of reliably diagnosed MD was estimated at 66%. Subjects with unreliably diagnosed MD reported fewer symptoms and, if diagnosed with MD only at the first interview, less impairment and help seeking, or, if diagnosed with MD only at the second interview, fewer episodes and a longer illness. A history of co-morbid GAD or PD is more prevalent among subjects with reliably diagnosed MD.Conclusions. A diagnosis of MD based on a single psychiatric interview incorporates a substantial amount of measurement error but there is no evidence that transient influences on recall and diagnosis index familial risk for MD. Quantitative indices of risk for MD based on multiple interviews should reflect both the characteristics of MD and the temporal order of positive diagnoses.

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