scholarly journals Intrinsic Functional Connectivity of Amygdala-Based Networks in Adolescent Generalized Anxiety Disorder

2013 ◽  
Vol 52 (3) ◽  
pp. 290-299.e2 ◽  
Author(s):  
Amy K. Roy ◽  
Julie L. Fudge ◽  
Clare Kelly ◽  
Justin S.A. Perry ◽  
Teresa Daniele ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Generalized Anxiety ◽  
Intrinsic Functional Connectivity

scholarly journals 1122 RESTING STATE FUNCTIONAL CONNECTIVITY IN PRIMARY INSOMNIA, GENERALIZED ANXIETY DISORDER AND CONTROLS

SLEEP ◽  
2017 ◽  
Vol 40 (suppl_1) ◽  
pp. A418-A418
Author(s):  
EF Pace-Schott ◽  
JP Zimmerman ◽  
RM Bottary ◽  
EG Lee ◽  
MR Milad ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Primary Insomnia ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity

scholarly journals Illness Severity Moderated Association Between Trait Anxiety and Amygdala-Based Functional Connectivity in Generalized Anxiety Disorder

2021 ◽  
Vol 15 ◽  
Author(s):  
Yang Du ◽  
Hailong Li ◽  
Hongqi Xiao ◽  
Mei Wang ◽  
Wei Zhang ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Trait Anxiety ◽  
Symptom Severity ◽  
Inferior Frontal Gyrus ◽  
Illness Severity ◽  
Anterior Cingulate ◽  
Generalized Anxiety ◽  
Significant Group

Trait anxiety is considered a vulnerability factor for the development of generalized anxiety disorder (GAD). The amygdala is related to both trait anxiety and GAD. Thus, we investigated amygdala-based functional connectivity (FC) in drug-naive non-comorbid GAD patients and explored its associations with personality, symptoms, and illness severity. FC analyses using the bilateral amygdala as seeds were performed with resting-state functional MRI data from 38 GAD patients and 20 matched healthy controls (HCs). Clinical characteristics were correlated with FC Z-scores from regions showing significant group differences. Furthermore, moderation analyses were used to explore the conditional effect of illness severity measured by the Clinical Global Impression–Severity (CGI-S) scale on the relationship between FC and trait anxiety. Relative to HCs, GAD patients showed hypoconnectivity between the amygdala and the rostral anterior cingulate cortex (rACC), inferior frontal gyrus (IFG), parahippocampal gyrus, and cerebellum and hyperconnectivity between the amygdala and the superior temporal gyrus (STG), insula, and postcentral gyrus. In GAD patients, amygdala–rACC connectivity was negatively associated with symptom severity and trait anxiety, and amygdala–IFG connectivity was positively associated with symptom severity. Moreover, CGI-S scores moderated the negative correlation between trait anxiety and amygdala–rACC FC. We demonstrate that there is extensive amygdala-based network dysfunction in patients with GAD. More importantly, amygdala–rACC connectivity plays a key role in the neural pathology of trait anxiety. Finally, the more severe the illness, the stronger the negative association between trait anxiety and amygdala–rACC FC. Our results emphasize the importance of personalized intervention in GAD.

scholarly journals Disrupted Amygdalar Subregion Functional Connectivity and Evidence of a Compensatory Network in Generalized Anxiety Disorder

2009 ◽  
Vol 66 (12) ◽  
pp. 1361 ◽  
Author(s):  
Amit Etkin ◽  
Katherine E. Prater ◽  
Alan F. Schatzberg ◽  
Vinod Menon ◽  
Michael D. Greicius
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Generalized Anxiety

scholarly journals Brain Functional Connectivity Correlates of Response in the 7.5% CO2 Inhalational Model of Generalized Anxiety Disorder: A Pilot Study

2020 ◽  
Vol 23 (4) ◽  
pp. 268-273
Author(s):  
Nathan T M Huneke ◽  
M John Broulidakis ◽  
Angela Darekar ◽  
David S Baldwin ◽  
Matthew Garner
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Interaction Analysis ◽  
Generalized Anxiety ◽  
Affective Valence ◽  
Potential Threat ◽  
Midcingulate Cortex ◽  
Psychophysiological Interaction ◽  
Co2 Challenge

Abstract Background The 7.5% CO2 inhalational model can be used to explore potential treatments for generalized anxiety disorder. However, it is unknown how inter-individual variability in the functional architecture of negative affective valence systems might relate to anxiogenic response in this model. Methods A total of 13 healthy volunteers underwent functional magnetic resonance imaging during a passive emotional face perception task. We explored task-evoked functional connectivity in the potential threat system through generalized psychophysiological interaction analysis. Within 7 days, these participants underwent prolonged 7.5% CO2 inhalation, and results from the generalized psychophysiological interaction analysis were correlated with CO2 outcome measures. Results Functional connectivity between ventromedial prefrontal cortex and right amygdala positively correlated with heart rate and subjective anxiety, while connectivity between midcingulate cortex and left amygdala negatively correlated with anxiety during CO2 challenge. Conclusions Response to CO2 challenge correlated with task-evoked functional connectivity in the potential threat system. Further studies should assess whether this translates into clinical populations.

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